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Öğe Allogenic versus Autogenous Bone Rings in Dental Implant Surgery: Guidance of Stress Analysis-Part II(Amer Scientific Publishers, 2018) Ozgul, Ozkan; Altay, Berkan; Atil, Fethi; Onder, M. Ercument; Tekin, Umut; Yilmaz, Seda; Kocyigit, Ismail DorukObjective The aim of this study is to compare the stress distribution along the alveolar bone following the allogenic and autogenous bone ring assisted immediate dental implant surgery using three dimensional finite element analyses Material and Methods Finite element models of maxilla and mandible that augmented with autogenous and allogenic bone ring graft with dental implant were created Vertical force of 100 N and oblique force of 100 N at 45(degrees) angle were applied to root formed design dental implant and abutment Results The highest calculated values of VonMisses (VM) stresses were observed in oblique loaded mandible model which augmented with allogenic graft In all models the highest VM stress values were greater for oblique loading compare to vertical loadings Allogenic bone ring grafts contribute the stresses more evenly through the implant, as for the autogenous grafts stresses are concentrated in the neck area of the implant Discussion Allogenic and autogenous grafts applied with implant placement create different stress distributions Stress distributions should be considered when choosing type of biomaterial.Öğe Bifosfanat kullanımına bağlı çenelerde gelişen osteonekrozlar: Çok merkezli retrospektif çalışma(2014) Süer, Berkay Tolga; Coşkunses, Fatih Mehmet; Sinanoğlu, Enver Alper; Atıl, Fethi; Koçyiğit, İsmail Doruk; Kan, Bahadır; Tekin, UmutBifosfonatlar (BP), metastatik kemik hastalıkları ve osteoporoz tedavisinde kullanılan kemik rezorbsiyonu inhibitörleridir. Bifosfanat kullanımına bağlı çenelerde gelişen osteonekroz (BBÇO), çenelerinde radyasyon tedavisi görmemiş, bifosfanat kullanan ya da kullanmış hastalarda mandibula ya da maksillada 8 haftadan daha uzun süren kemik ekspozu ile karakterize bir durum olarak tanımlanmıştır. Bu çalışmada farklı merkeze yönlendirilen BBÇO vakaları retrospektif olarak sunulmuştur. 2012 ve 2013 yıllarında GATA Haydarpaşa Eğitim Hastanesi Diş Hekimliği, Kocaeli Üniversitesi Diş Hekimliği Fakültesi, ve Kırıkkale Üniversitesi Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Cerrahisi kliniklerine başvuran BBÇO tanısı konulmuş 18 hastanın demografik özellikleri, anamnez bulguları, klinik muayene bulguları, bifosfanat çeşidi ve kullanım bilgileri (süre, uygulama yolu) ve eğer varsa ilgili sebep açısından değerlendirmeleri yapılmıştır. Hastaların 12' sinde mandibula (% 67), 5' inde maksilla (%28) ve 1 hastada ise hem mandibula hem maksillada (%5) BBÇO izlendi. Hastaların 2 tanesi osteoporozis (% 11) nedeniyle 16 hasta ise (% 89) onkolojik tedavi nedeniyle bifosfanat grubu ilaç kullanmaktaydı. Tıp ve diş hekimliğini ortak olarak ilgilendiren konu olması itibariyle bifosfanat grubu ilaç tedavisine başlanacak hasta gruplarının ortak klinikler tesis edilerek takip edilmeleri ve bilgi paylaşımlarıyla ortaya çıkabilecek olası komplikasyonların azaltılabileceğini düşünmekteyiz.Öğe Biomimetic dental implant production using selective laser powder bed fusion melting: In-vitro results(Elsevier, 2024) Önder, M. Ercüment; Çulhaoğlu, Ahmet; Özgül, Özkan; Tekin, Umut; Atil, Fethi; Taze, Cem; Yasa, EvrenInstead of a textured surface with irregular pore size and distribution as in conventional dental implants, the use of lattice structures with regular geometric structure and controlled pore size produced by selective laser powder bed fusion melting (LPDF) technique will provide more predictable and successful results regarding osseointe- gration and mechanics. In this study, biomimetic dental implants with 2 different pore designs were fabricated by LPDF technique and compared with conventional dental implants in terms of surface characterization and resistance to biomechanical forces. Finite element analysis, scanning electron microscopy, computed micro to- mography scanning, ISO 14801 tests and detork tests were used for the comparison. The tested biomimetic implants were found to be as durable as conventional implants in terms of mechanical strength and detork values. They were also found to be 40-60% more advantageous than conventional dental implants with respect to surface area and volume. As a result, it was concluded that biomimetic dental implants with sufficient me- chanical strength and complex surface geometries can be made as designed without changing the reliable base material and can be produced using a different manufacturing method.Öğe Clinical Evaluation of the Use of Tibial Bone Grafting in Dentoalveolar Reconstructive Surgery(Karger, 2016) Atil, Fethi; Kocyigit, Ismail Doruk; Suer, Berkay Tolga; Alp, Yunus Emre; Yazan, Murude; Tekin, Umut; Tuz, Hakan H.Objective: The aim of this study was to evaluate the efficacy of tibial autogenous bone grafting in the treatment of patients with alveolar bone defects. Materials and Methods: The study subjects consisted of 12 patients (10 male, 2 female, age: 19-51 years) who underwent reconstructive autogenous bone-grafting procedures. The medial approach to the tibial bone was used to harvest autogenous cancellous bone grafts in all the patients. Clinical parameters (complications at the donor and recipient sites, resorption and volume of the grafts) were evaluated retrospectively. Results: The mean age of the patients was 36.25 +/- 0.9 years. Of the 12 patients, 5 (41.7%) received bone grafts for sinus augmentation, 3 (25%) for cyst cavity reconstruction and 4 (33.3%) for alveolar cleft reconstruction procedures. The average follow-up period was 28.4 months (range: 21-40 months). An average of 5.2 cm(3) of cancellous bone was harvested for grafting procedures. All the grafting procedures were successful, and there were no surgical complications during the harvesting protocol. In all cases, pain and gait disturbance lasted less than 2 weeks. Conclusion: The results of this study suggest that the use of tibial autogenous bone graft harvested using a medial approach was a safe, simple and effective method for grafting various alveolar bone defects where high amounts of cancellous bone grafts were needed with low morbidity. (C) 2015 S. Karger AG, BaselÖğe Correction of Postsurgical Alveolar Ridge Defect With Vertical Alveolar Distraction of the Onlay Block Graft(Lippincott Williams & Wilkins, 2012) Kocyigit, Ismail Doruk; Tuz, Hakan H.; Alp, Yunus Emre; Atil, Fethi; Tekin, Umut; Coskunses, Fatih MehmetAlveolar bone augmentation for dental implant rehabilitation is one of the greatest challenges for oral and maxillofacial surgeons. Bringing out an inadequate quantity of vertical bone during augmentation compromises correct implant positioning and the resulting prosthetic restoration. Alveolar distraction osteogenesis is now generally used in correcting alveolar ridge atrophy due to trauma, congenital defects, or periodontal defects. Onlay block grafting is a suitable method for restoring the alveolar bony defects. However, it sometimes can become a complicated procedure to repair the horizontal defect accompanying a vertical defect using only bone blocks. This clinical report presents a successful reconstruction of a severe anterior mandibular alveolar bony defect as a result of impacted teeth extraction and periodontal problem in a 50-year-old healthy female patient. The defect was reconstructed with symphysis graft and platelet-rich fibrin in the first step. Vertical alveolar distraction was performed on the grafted site to maintain the suitable bony height 3 months later. Grafted bony segment distraction and the treatment options in similar cases were also discussed in this clinical report among with the literature.Öğe Diagnosis and treatment of keratocystic odontogenic tumor mimicking a dentigerous cyst in panaromic radiography(2017) Okkesima, Alime; Adışen, Mehmet Zahit; Mısırlıoğlu, Melda; Tekin, UmutKeratokistik odontojenik tümör (KKOT) odontojenik kaynaklı, dental laminadan gelişen ve tümör olarak sınıflandırılan kistik bir lezyondur. KKOT orofasiyal bölgede maxilla ve mandibulada, sıklıkla da mandibulanın ramus ve angulus bölgelerinde görülür. Agresif davranış gösteren ve nüksetme oranı yüksek benign bir neoplazmdır. Radyografik olarak lezyonlar yuvarlak veya oval şekilli, bazen de tarak şeklinde multiloküler görüntü sergiler ve gömülü bir diş ile ilişkili olabilir. Bu vaka raporunda, sol alt gömülü üçüncü molar diş ile ilişkili, iyi sınırlı ve geniş uniloküler radyolüsent bir lezyon rutin panoramik radyografik incelemede tesadüfen tespit edildi. İleri görüntüleme amacıyla bölgeden konik ışınlı bilgisayarlı tomografi (KIBT) görüntüleri alındı. Lezyonun radyografik özelliklerine göre dentigeröz kist ön tanısı kondu. Hasta olası tedavi seçenekleri için Ağız Diş ve Çene Cerrahisi Anabilim Dalı'na konsülte edildi. Tedavide ilk olarak lokal anestezi altında marsupializasyon işlemi gerçekleştirildi. İlk operasyondan 4 ay sonra lezyon boyutları küçüldüğünde, cerrahi olarak enükleasyon yapıldı. Histopatolojik incelemede lezyonun parakeratinize epitel ile çevrili olmasından dolayı kesin teşhis olarak KKOT olduğu rapor edildiÖğe Effect of Locally Administered Alendronate on Onlay Grafts(Amer Scientific Publishers, 2017) Tekin, Umut; Ozgul, Ozkan; Tuz, Hakan; Korkusuz, Petek; Kocyigit, Ismail Doruk; Atil, Fethi; Onder, M. ErcumentObjective: The present study compared the effects of local alendronate application on the osteogenesis of autogenous and xenogenous onlay grafts implanted in rabbit mandibles. Material and Methods: 28 New Zealand rabbits were used in this experimental animal study. The animals were randomly divided into 4 groups according to graft material as follows: D1: autogenous graft-saline; D2: 60% autogenous graft-40% alendronate D3: xenogenous bone graft-saline; D4: 60% xenogenous graft-40% alendronate. 3 histologic parameters were evaluated: the ratio of new bone formation to the total defect area, the active osteoblast-lined bone length, and the ratio of osteocyte-filled lacunae to total lacunae. At the same time, the grafted zones were evaluated using dual-energy X-ray absorptiometry (DEXA) and the Bone mineral density scores were measured. Results: The present study showed better results for the group receiving alendronate applied to autogenous graft when compared to other groups. Discussion: The administration of alendronate increases the resistance of autogenous graft; it may also enhance new bone formation and increase the viability of xenograft. Further animal studies supported with biomechanical tests are required prior to human studies.Öğe Effect of Platelet-Rich Fibrin on Peripheral Nerve Regeneration(Lippincott Williams & Wilkins, 2016) Senses, Fatma; Onder, Mustafa E.; Kocyigit, Ismail D.; Kul, Oguz; Aydin, Gueluemser; Inal, Elem; Tekin, UmutPurpose:This study aimed to evaluate the effect of platelet-rich fibrin (PRF) on peripheral nerve regeneration on the sciatic nerve of rats by using functional, histopathologic, and electrophysiologic analyses.Materials and Methods:Thirty female Wistar rats were divided randomly into 3 experimental groups. In group 1 (G1), which was the control group, the sciatic nerve was transected and sutured (n=10). In group 2 (G2), the sciatic nerve was transected, sutured, and then covered with PRF as a membrane (n=10). In group 3 (G3), the sciatic nerve was transected, sutured by leaving a 5-mm gap, and then covered by PRF as a nerve guide (n=10). Functional, histopathologic, and electrophysiologic analyses were performed.Results:The total histopathologic semiquantitative score was significantly higher in G1 compared to G2 and G3 (P<0.05). Myelin thickness and capillaries were significantly lower in G3 compared to G1 (P<0.05). There was no statistically significant difference between the groups with regard to the functional and electrophysiologic results.Conclusion:The study results suggest that PRF decreases functional recovery in sciatic nerve injury. Further studies are required to determine the efficacy of PRF on peripheral nerve regeneration.Öğe Effect of Systemic Oxytocin Administration on New Bone Formation and Distraction Rate in Rabbit Mandible(W B SAUNDERS CO-ELSEVIER INC, 2020) Altay, Berkan; Dede, Eda Ciftci; Ozgul, Ozkan; Atil, Fethi; Kocyigit, Ismail Doruk; Orhan, Kaan; Tekin, UmutPurpose: The main disadvantage of distraction osteogenesis is the prolonged treatment protocol. Recently, oxytocin (OT) has been found to have anabolic effects on bone metabolism. In this experimental study, the effects of OT on the mandibular distraction gap in rabbits at 2 different distraction rates were evaluated. Materials and Methods: This experimental study was conducted on 28 male New Zealand white rabbits. The animals were divided into 3 experimental groups and 1 control group. Group A (control group, n = 7) consisted of animals with distraction at a rate of 1 mm/day, and group B (n = 7) consisted of animals with a distraction rate of 2 mm/day; groups A and B received postoperative saline solution injection. Group C (n = 7) consisted of animals with distraction at a rate of 1 mm/day, and group D (n = 7) consisted of animals with a distraction rate of 2 mm/day; postoperative OT injection was performed in groups C and D. Results: Both histomorphologic and micro-computed tomography evaluations showed increased bone healing in the OT-treated groups. Conclusions: On the basis of the evaluation of both the histomorphometric and micro-computed tomographic data, systemic OT administration was found to increase new bone formation and bone healing with distraction osteogenesis. (C) 2020 American Association of Oral and Maxillofacial SurgeonsÖğe Effects of alendronate on rate of distraction in rabbit mandibles(W B Saunders Co-Elsevier Inc, 2008) Tekin, Umut; Tuz, Hakan H.; Onder, Ercument; Ozkaynak, Ozkan; Korkusuz, PetekPurpose: Bisphosphonates are used for inhibiting bone resorption in several diseases. In this experimental study, the effects of alendronate on the mandibular distraction gap in rabbits at 2 different rates were evaluated. Materials and Methods: The study was performed using 15 New Zealand white rabbits. Group I consisted of animals with distraction at the rate of 1 mm/day. Group 2 consisted of animals with distraction at the rate of 2 mm/day. These experimental groups had a postoperative alendronate injection during the first 3 days of their distraction phase. Group 3 consisted of animals with distraction at the rate of 1 mm/day, without alendronate injections. Distraction was performed on only the left sides of all animals until a gap of 10 nun was achieved. On postoperative day 45, the animals were sacrificed, and the mandibles of all animals were evaluated radiographically and histologically, and with dual-energy x-rdy absorptiometry (DEXA). Radiographic images were also evaluated using transmission densitometry (TD). Results: Histologically, bone healing was found to be significantly accelerated in groups I and 2 compared with group 3 (P < .05). Bone healing was superior in group 2, but the difference was not statistically significant compared with group 1. The TD results revealed no statistical difference between experimental groups, whereas the results for group 2 showed significantly denser osteogenic formation in the distraction gap compared with group 3. There was a significant increase in mean bone mineral density in the experimental groups compared with the control group. Conclusion: Histologic, TD, and DEXA results showed that alendronate injections during the distraction phase may be effective in accelerating new bone formation in the distraction gap in rabbit mandibles. The TD results also support the concept that an administration of alendronate may allow a 2 mm/day elongation instead of I mm/day in the rabbit mandible. (C) 2008 American Association of Oral and Maxillofacial Surgeons.Öğe Effects of Local Low-Dose Alendronate Injections Into the Distraction Gap on New Bone Formation and Distraction Rate on Distraction Osteogenesis(Lippincott Williams & Wilkins, 2017) Alp, Yunus Emre; Taskaldiran, Alper; Onder, Mustafa Ercument; Karahan, Siyami; Kocyigit, Ismail Doruk; Atil, Fethi; Tekin, UmutBisphosphonates that constrain bone resorption have a direct effect on osteoclast function. In this experimental study, the effects of low-dose local alendronate injections on the distraction gap (DG) in rabbit mandible at 2 different rates were evaluated. The experimental study was conducted on 20 male, New Zealand white rabbits. The animals were divided into 3 experimental groups and 1 control group. Group 1 consisted of animals with distraction at the rate of 1 mm/day, receiving postoperative local low-dose alendronate local injections into the DG. Group 2 consisted of animals with distraction at the rate of 2 mm/day, receiving postoperative 0.75 mu g/kg of alendronate local injections into the DG. Group 3 consisted of animals with distraction at the rate of 2 mm/day, receiving postoperative 0.2 mL local saline injections into the DG. Group 4 consisted of animals with distraction at the rate of 1 mm/day, receiving postoperative 0.2 mL local saline injections into the DG. All the injections were performed immediately postoperatively and for all groups at 1, 2, 3, and 4 weeks following surgery. The distraction zones were evaluated using dual-energy X-ray absorptiometry and histological analysis. Histologically, bone healing was found to be significantly accelerated in Groups 1 and 4 compared with Groups 2 and 3 (P<0.05). Bone healing was superior in Group 1 and the difference was statistically significant compared with Group 4. There was a significant increase in mean bone mineral density in the 1 mm daily rate groups (Groups 1 and 4) compared with the 2 mm daily rate groups (Groups 2 and 3) (P<0.05). Local low-dose alendronate injections could be an effective way for improving bone formation in distraction osteogenesis. Furthermore, the results of this study did not support the hypothesis that injections of local low-dose alendronate may allow 2 mm/day instead of 1 mm/day of elongation in the rabbit mandible.Öğe Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: Randomized multicenter split-mouth clinical trial(Biomed Central Ltd, 2015) Özgül, Özkan; Şenses, Fatma; Er, Nilay; Tekin, Umut; Tuz, Hakan Hifzi; Alkan, Alper; Atil, FethiBackground: Impacted third molar removal is a routine procedure in oral and maxillofacial surgery. Platelet-rich fibrin (PRF) is a second generation platelet concentration which is produced by simplified protocol. The aim of this study was to assess the effectiveness of PRF in the healing process by evaluating the changes in pain and swelling after third molar surgery. Methods: Fifty-six patients (23 male, 33 female) who provide the inclusion criteria were selected to participate in this study. The evaluation of the facial swelling was performed by using a horizontal and vertical guide. The pain was evaluated in the postoperative period using a visual analog scale (VAS) of 100 mm. Results: Horizontal and vertical measurements showed more swelling at the control side (without PRF) in 3th day postoperatively (p < 0.05). There were no statistically significant differences regarding pain among the groups. Conclusion: As a conclusion, PRF seems to be effectiveness on postoperative horizontal swelling after third molar surgery. PRF could be used on a routine basis after third molar extraction surgery.Öğe Evaluation of Advanced Platelet Rich Fibrin (A-PRF) on Bone Healing. Is It Better than Old Version? A Histological Animal Study(Amer Scientific Publishers, 2017) Titirinli, Kubra; Tekin, Umut; Atil, Fethi; Onder, M. Ercument; Senguven, Burcu; Ozgul, Ozkan; Kocyigit, Ismail DorukObjective: This study aims to evaluate the effect of fibrin, which is formed with an alteration to the standard PRF centrifugation protocol, on the bone formation. The study additionally aims to assess cell-distribution, and to evaluate the effects of alterations in the speed and duration of centrifugation on the changes in cell-distribution and the formation of hard tissue, by making histological investigations. Materials and methods: Ten New Zealand rabbits were used in this experimental animal study. PRF (2700 rpm, 12 min) and APRF (1500 rpm, 14 min) were placed in the standard bone defects that formed in the right corpus of the mandible randomly. No additional material was placed in the left mandible defect, as a control group. Rabbits were sacrificed after two months, the histological evaluation was performed. Results: There were no marked differences between groups in regard to the quantity of bone formation and bone quality. The quantities of new bone formation were (mean) 56.9%, 55%, 42.5%. Discussion: It may be considered that PRF and its variations have positive effects on the new bone tissue and cell number, and may lead to more rapid ossification compared to the unprocessed bone defects.Öğe Finite-Element Analysis of a New Designed Miniplate which is Used via Intraoral Approach to the Mandible Angle Fracture: Comparison of the Different Fixation Techniques(Lippincott Williams & Wilkins, 2015) Coskunses, Fatih Mehmet; Kocyigit, Ismail Doruk; Alil, Fethi; Tekin, Umut; Suer, Berkay Tolga; Tuz, Hakan Hifzi; Yagiz, AyberkThe mandible is the largest facial bone as well as the most commonly fractured bone in the maxillofacial region. Despite numerous studies conducted to identify optimal treatment modalities and plates configurations for intraoral and transoral approaches, no definitive conclusion has been reached. This study used finite element analysis (FEA) to assess 4 scenarios for treatment of an angle fracture (6-hole noncompression miniplate; 6-hole single plate/Champy's technique, 3D strut plate; 2 parallel 4-hole noncompression miniplates). Analysis included segmental displacement and Von Mises Stress evaluations of a 3D reconstruction of a human mandible. Von Mises Stress values for plates did not vary significantly among treatment groups. Moreover, no significant differences were observed in cumulative displacement of segments subjected to vertical and horizontal loads, with all treatment configurations demonstrating clinical acceptability.Öğe Investigation of the Sodium Titanate Surface Behavior in Corrosive Oral Fluids by Comparing with Conventional Titanium Surfaces(2021) Çulhaoğlu, Ahmet Kürşad; Özgül, Özkan; Tekin, Umut; Önder, ErcümentObjective: Titanium (Ti) and Ti alloys are suitable options as implant material because they are biocompatible and form a corrosion protective titanium oxide layer. However, the oxide layer issensitive to corrosive ions such as fluoride (F) and hydrogen peroxide(H2O2) which are normally found in human mouth. Commercially produced toothpastes, mount rinses and cariostatic gels contain between0.1% and 1% content F concentration. Furthermore, H2O2 can be secreted during inflammatory reactions by bacteria in oral environment.The corrosion of dental implants and components can cause failure ofdental implant treatment. The aim of this study was to analyse the effects of different F and H2O2 concentrations on different treated Ti alloy(Ti6Al4V) in surfaces. Material and Methods: The effects of different F (0.5%, 2.5%) and H2O2 (0.1%, 10%) concentrations on differenttreated Ti6Al4V surfaces [electro-polished, roughed, fine-roughed andsodium titanate-treated (NaTi)] were analysed. Scanning electron microscopy and inductively coupled plasma with optical emission spectrometer provided quantitative bulk elemental composition for Tisamples. Results: Median corrosion values of Ti (mg/L) and V (mg/L)corrosion levels in 10% H2O2 and 2.5% F solutions were significantlyhigher than 0.1% H2O4, 0.5% F and control solutions. Median Ti corrosion values observed in electro-polished, roughed and fine-roughedgroups were statistically higher than NaTi treated surfaces. Conclusion: This study shows that low ion release on NaTi surfaces causesthe least amount of corrosion. Consequently, NaTi coating should beconsidered as the best alternative for protecting Ti surfaces from corrosion.Öğe Is Autogenous Abdominal Fat Transplantation Into a Large Temporomandibular Joint Defect Following Removal of Failed Alloplastic Prosthesis a Definitive Treatment?(W B Saunders Co-Elsevier Inc, 2014) Tekin, Umut; Keller, Eugene E.; DeLone, David R.Purpose: To evaluate the long-term clinical outcome after the removal of failed major alloplastic temporomandibular joint (TMJ) implants and the placement of an autologous abdominal fat graft. Materials and Methods: A long-term clinical follow-up was performed in 4 patients who underwent removal of a failed alloplastic implant and insertion of an autologous abdominal fat graft under 1-stage surgical management. Postsurgical use of pain medication was documented and the vertical interincisal opening measurement was obtained at the follow-up visit. Long-term computed tomographic (CT) scans were available for 3 of 4 patients and evaluated for fat graft retention by a radiologist. Hounsfield units were used. Results: The study showed long-term(average, 4.7 years) clinical success, including normal jaw function (>= 30-mm vertical opening) and freedom from the use of pain-relieving medication. Long-term CT scans (average, 5 years after surgery) documented fat graft retention in 3 patients (-80 HU). Conclusion: Autogenous fat graft placement alone, after major TMJ alloplastic removal, provides excellent long-term clinical success. (C) 2014 American Association of Oral and Maxillofacial SurgeonsÖğe Is the Level of Nitric Oxide in the Dental Follicular Tissues of Impacted Third Molars With a History of Recurrent Pericoronitis a True Marker of Oxidative Stress?(W B Saunders Co-Elsevier Inc, 2017) Hendek, Meltem Karsiyaka; Senses, Fatma; Kisa, Ucler; Aksoy, Nurkan; Tekin, UmutPurpose: Nitric oxide (NO) is an indicator of oxidative stress in several tissues. Its role in dental follicular (DF) tissues of impacted third molars with a history of recurrent pericoronitis is not well elucidated. The present study compared NO levels between inflamed and noninflamed DF tissues of impacted third molars with a history of recurrent pericoronitis. Materials and Methods: A cross-sectional study was designed. The study sample included inflamed DF tissues (test group) with certain local inflammatory symptoms, such as pain, tenderness, swelling, and erythema and noninflamed DF tissues (control group) without local inflammatory symptoms of impacted mandibular third molars. Each patient contributed only 1 specimen to the samples. All tissues samples were biochemically investigated for NO levels as an indicator of oxidative stress. The primary predictor variable was inflammatory status; secondary predictor variables were age and gender. The primary outcome variable was NO level. Descriptive and comparative analyses were conducted. Results: The test group consisted of 57 patients (28 men, 29 women; mean age, 23.28 +/- 5.16 yr) and the control group consisted of 57 patients (30 men, 27 women; mean age, 23.02 +/- 5.42 yr). No relevant inter-group differences were noted for demographic findings such as age and gender. NO levels were significantly higher in inflamed DF tissues of impacted third molars than in noninflamed DF tissues (P < .05). Conclusion: Results of this study showed that NO might be used as an indicator of oxidative stress and the necessity to remove impacted mandibular third molars with a history of recurrent pericoronitis. (C) 2017 American Association of Oral and Maxillofacial Surgeons.Öğe Kondil kırıklarında tedavi yaklaşımları(2020) Bolat, İsmail Eser; Tekin, UmutKondil kırıkları maksillofasiyal kırıklar içerisinde sık görülmektedir. Tedavi edilmeyen veya yanlış tedavi edilen kondil kırıkları ciddi sonuçlara neden olabilmektedir. Kondil kırıklarının tedavisi bölge anatomisine komşu bulunan birçok önemli vital yapı nedeniyle her zaman tartışmalı bir konu olmuştur. Bu kırıkların sınıflandırılmasında ve tedavisinde birçok farklı yöntem bildirilmiştir. Kondil kırıklarının tedavisinde günümüzde kullanılan başlıca yöntemler kapalı redüksiyon ve açık redüksiyon olarak iki ana grupta toplanabilir. Kapalı redüksiyon tedavisi uzun bir dönem kondil kırıklarının tedavisinde ilk tercih olmuştur. Osteosentez materyallerindeki gelişmeler sayesinde açık redüksiyon tedavisi giderek daha popüler hale gelmektedir. Kondil kırıklarının tedavinde; kırık fragmanların durumu, hastanın yaşı ve klinik semptomları göz önünde bulundurularak en uygun tedavi yöntemi tercih edilmelidir. Bu makalede, kondil kırıklarının sınıflandırılması ve tedavisinde bildirilen güncel ve farklı tedavi yöntemleri değerlendirilmiş ve gözden geçirilmiştir.Öğe Malondialdehyde Levels in Dental Follicles of Asymptomatic Impacted Third Molars(W B Saunders Co-Elsevier Inc, 2011) Tekin, Umut; Kisa, Ucler; Guven, Orhan; Kurku, HuseyinPurpose: Increased levels of reactive oxygen species lead to oxidative stress and tissue damage. Malondialdehyde (MDA) is one of many low-molecular-weight endproducts of lipid peroxidation that increases with oxidative stress. The aim of this study was to determine oxidative stress in dental follicles (DFs) of radiologically asymptomatic impacted third molars (ITMs) using MDA. Materials and Methods: This study involved 40 DFs of 40 patients referred for clinically and radiographically asymptomatic ITMs. Forty healthy gingival tissues in the same patients were obtained during surgical removal of teeth as a control group. DF widths on periapical radiographs narrower than 2.5 mm were included in the study. All tissues samples were analyzed for MDA as an indicator of oxidative stress. Results: Levels of MDA were significantly higher in DFs from ITMs than those from healthy gingival tissues of the same patients (P < .01). Conclusion: The results suggest that significant oxidative stress may occur in DFs of asymptomatic ITMs. The findings suggest that increased MDA may play an important role in oxidative stress in DFs. In light of these preliminary findings of the present study, further investigations and comprehensive studies are required to determine the role of antioxidants that scavenge free radicals in DFs. (C) 2011 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 69:1291-1294, 2011Öğe
