Effect of Platelet-Rich Fibrin on Peripheral Nerve Regeneration
Yükleniyor...
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose:This study aimed to evaluate the effect of platelet-rich fibrin (PRF) on peripheral nerve regeneration on the sciatic nerve of rats by using functional, histopathologic, and electrophysiologic analyses.Materials and Methods:Thirty female Wistar rats were divided randomly into 3 experimental groups. In group 1 (G1), which was the control group, the sciatic nerve was transected and sutured (n=10). In group 2 (G2), the sciatic nerve was transected, sutured, and then covered with PRF as a membrane (n=10). In group 3 (G3), the sciatic nerve was transected, sutured by leaving a 5-mm gap, and then covered by PRF as a nerve guide (n=10). Functional, histopathologic, and electrophysiologic analyses were performed.Results:The total histopathologic semiquantitative score was significantly higher in G1 compared to G2 and G3 (P<0.05). Myelin thickness and capillaries were significantly lower in G3 compared to G1 (P<0.05). There was no statistically significant difference between the groups with regard to the functional and electrophysiologic results.Conclusion:The study results suggest that PRF decreases functional recovery in sciatic nerve injury. Further studies are required to determine the efficacy of PRF on peripheral nerve regeneration.
Açıklama
Onder, M Ercument/0000-0002-1488-616X; ATIL, Fethi/0000-0002-8286-4819
Anahtar Kelimeler
Nerve regeneration, PRF, rat, sciatic nerve
Kaynak
Journal Of Craniofacial Surgery
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
27
Sayı
7
Künye
closedAccess
