Effect of Platelet-Rich Fibrin on Peripheral Nerve Regeneration
dc.contributor.author | Senses, Fatma | |
dc.contributor.author | Onder, Mustafa E. | |
dc.contributor.author | Kocyigit, Ismail D. | |
dc.contributor.author | Kul, Oguz | |
dc.contributor.author | Aydin, Gueluemser | |
dc.contributor.author | Inal, Elem | |
dc.contributor.author | Tekin, Umut | |
dc.date.accessioned | 2020-06-25T18:16:09Z | |
dc.date.available | 2020-06-25T18:16:09Z | |
dc.date.issued | 2016 | |
dc.department | Kırıkkale Üniversitesi | |
dc.description | Onder, M Ercument/0000-0002-1488-616X; ATIL, Fethi/0000-0002-8286-4819 | |
dc.description.abstract | Purpose:This study aimed to evaluate the effect of platelet-rich fibrin (PRF) on peripheral nerve regeneration on the sciatic nerve of rats by using functional, histopathologic, and electrophysiologic analyses.Materials and Methods:Thirty female Wistar rats were divided randomly into 3 experimental groups. In group 1 (G1), which was the control group, the sciatic nerve was transected and sutured (n=10). In group 2 (G2), the sciatic nerve was transected, sutured, and then covered with PRF as a membrane (n=10). In group 3 (G3), the sciatic nerve was transected, sutured by leaving a 5-mm gap, and then covered by PRF as a nerve guide (n=10). Functional, histopathologic, and electrophysiologic analyses were performed.Results:The total histopathologic semiquantitative score was significantly higher in G1 compared to G2 and G3 (P<0.05). Myelin thickness and capillaries were significantly lower in G3 compared to G1 (P<0.05). There was no statistically significant difference between the groups with regard to the functional and electrophysiologic results.Conclusion:The study results suggest that PRF decreases functional recovery in sciatic nerve injury. Further studies are required to determine the efficacy of PRF on peripheral nerve regeneration. | en_US |
dc.description.sponsorship | Kirikkale University, Scientific Project DepartmentKirikkale University [201299] | en_US |
dc.description.sponsorship | This research was supported by Kirikkale University, Scientific Project Department with number of 201299. | en_US |
dc.identifier.citation | closedAccess | en_US |
dc.identifier.doi | 10.1097/SCS.0000000000003066 | |
dc.identifier.endpage | 1764 | en_US |
dc.identifier.issn | 1049-2275 | |
dc.identifier.issn | 1536-3732 | |
dc.identifier.issue | 7 | en_US |
dc.identifier.pmid | 27763975 | |
dc.identifier.scopus | 2-s2.0-85018194001 | |
dc.identifier.scopusquality | Q3 | |
dc.identifier.startpage | 1759 | en_US |
dc.identifier.uri | https://doi.org/10.1097/SCS.0000000000003066 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/6435 | |
dc.identifier.volume | 27 | en_US |
dc.identifier.wos | WOS:000386352100089 | |
dc.identifier.wosquality | Q4 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | |
dc.publisher | Lippincott Williams & Wilkins | en_US |
dc.relation.ispartof | Journal Of Craniofacial Surgery | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Nerve regeneration | en_US |
dc.subject | PRF | en_US |
dc.subject | rat | en_US |
dc.subject | sciatic nerve | en_US |
dc.title | Effect of Platelet-Rich Fibrin on Peripheral Nerve Regeneration | en_US |
dc.type | Article |
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