Effect of Platelet-Rich Fibrin on Peripheral Nerve Regeneration

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dc.contributor.authorSenses, Fatma
dc.contributor.authorOnder, Mustafa E.
dc.contributor.authorKocyigit, Ismail D.
dc.contributor.authorKul, Oguz
dc.contributor.authorAydin, Gueluemser
dc.contributor.authorInal, Elem
dc.contributor.authorTekin, Umut
dc.date.accessioned2020-06-25T18:16:09Z
dc.date.available2020-06-25T18:16:09Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionOnder, M Ercument/0000-0002-1488-616X; ATIL, Fethi/0000-0002-8286-4819
dc.description.abstractPurpose:This study aimed to evaluate the effect of platelet-rich fibrin (PRF) on peripheral nerve regeneration on the sciatic nerve of rats by using functional, histopathologic, and electrophysiologic analyses.Materials and Methods:Thirty female Wistar rats were divided randomly into 3 experimental groups. In group 1 (G1), which was the control group, the sciatic nerve was transected and sutured (n=10). In group 2 (G2), the sciatic nerve was transected, sutured, and then covered with PRF as a membrane (n=10). In group 3 (G3), the sciatic nerve was transected, sutured by leaving a 5-mm gap, and then covered by PRF as a nerve guide (n=10). Functional, histopathologic, and electrophysiologic analyses were performed.Results:The total histopathologic semiquantitative score was significantly higher in G1 compared to G2 and G3 (P<0.05). Myelin thickness and capillaries were significantly lower in G3 compared to G1 (P<0.05). There was no statistically significant difference between the groups with regard to the functional and electrophysiologic results.Conclusion:The study results suggest that PRF decreases functional recovery in sciatic nerve injury. Further studies are required to determine the efficacy of PRF on peripheral nerve regeneration.en_US
dc.description.sponsorshipKirikkale University, Scientific Project DepartmentKirikkale University [201299]en_US
dc.description.sponsorshipThis research was supported by Kirikkale University, Scientific Project Department with number of 201299.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/SCS.0000000000003066
dc.identifier.endpage1764en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue7en_US
dc.identifier.pmid27763975
dc.identifier.scopus2-s2.0-85018194001
dc.identifier.scopusqualityQ3
dc.identifier.startpage1759en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000003066
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6435
dc.identifier.volume27en_US
dc.identifier.wosWOS:000386352100089
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Craniofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNerve regenerationen_US
dc.subjectPRFen_US
dc.subjectraten_US
dc.subjectsciatic nerveen_US
dc.titleEffect of Platelet-Rich Fibrin on Peripheral Nerve Regenerationen_US
dc.typeArticle

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