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    The effects of HES 130 / 0,4 application on erythrocyte deformability in ureteral obstructed rats
    (Wiley, 2017) Kalayci, D.; Kucuk, A.; Sen, O.; Comu, F. M.; Arslan, M.; Unal, Y.
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    The effects of low and high doses of sugammadex on kidney tissue in streptozotocin-induced diabetic rats
    (Comenius Univ, 2015) Kip, G.; Turgut, H. C.; Alkan, M.; Aydin, M. E.; Erbatur, M. E.; Kiraz, H. A.; Unal, Y.
    BACKGROUND: Sugammadex is primarily excreted via renal route. We investigated effects of low and high doses of sugammadex (16 mg/kg versus 96 mg/kg) on renal tissue samples of streptozotocin-induced diabetic rats. MATERIAL AND METHODS: Twenty-four Wistar albino rats were divided into 4 groups. Group C (control - 0.9 % NaCl), Group DC (diabetes control; 55 mg/kg streptozotocin, IP, only), Group DR-16S (diabetes-rocuronium - 16 mg sugamnnadex, IV.) and Group DR-96S (diabetes- rocuronium - 96 mg sugammadex, IV). Renal tissue histopathological evaluation and antioxidant status (measurements of MDA levels and NO activities) were studied. RESULTS: Significantly higher levels of all inflammation parameters (inflammation, degeneration/necrosis, tubular dilatation, tubular cell degeneration, dilatation in Bowman's space, tubular hyaline casts, and lymphocyte infiltration) were found in the 96 mg/kg sugammadex group. Higher MDA tissue levels and lower NO activity were found in the 96 mg/kg sugammadex group. DISCUSSION: We can conclude that high-dose (96 mg/kg) sugammadex administration resulted in significant renal tissue damage in diabetic rats. As a consequence, low doses of sugamnnadex have to be preferred in diabetic patients (Tab. 2, Fig. 4, Ref. 26). Text in PDF www.elis.sk.
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    The effects of propofol and memantine on erythrocyte deformability
    (Comenius Univ, 2014) Unal, Y.; Comu, F. M.; Emik, U.; Alkan, M.; Pampal, H. K.; Arslan, M.
    Objective: Propofol is an intravenous general anesthetic with a primary hypnotic effect. Memantine is an NMDA receptor antagonist that has been shown to reverse changes in memory and synaptic plasticity in animal models. This study aims to investigates whether propofol and/or memantine has any effects on erythrocyte deformability. Methods: 24 Wistar albino rats were divided randomly into four groups. Group P received 150 mg.kg(-1) propofol intraperitoneally (ip); Group M received 1 mg.kg(-1) memantine (ip); Group PM received 1 mg.kg(-1) memantine mg.kg(-1) ip 30 minutes before the administration of 150 mg.kg(-1) propofol; and the control group (Group C) received saline ip. Euthanasia was performed in all rats by using intraabdominal blood uptake. The heparinized whole blood samples were used to prepare erythrocyte suspensions, from which erythrocyte suspensions were formed with a PBS buffer solution containing 5 % htc, and the deformability parameters were measured. Results: Erythrocyte deformability was significantly higher in Groups P, M and PM when compared to the Group C(p = 0.007 and p = 0.001, p<0.0001, respectively); while the erythrocyte deformability indices were similar in groups P, M and PM. Conclusion: The administration of propofol and memantine altered the erythrocyte deformability in the rats, which may lead to further problems in microcirculation. The administration of memantine to the propofol-treated rats did not alter the erythrocyte deformability; however the early results should be verified through further experimental and clinical studies (Fig. 1, Ref. 23). Text in PDF www.elis.sk.
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    Evaluation of effects of hyperthermic intraperitoneal chemotherapy treatment on erythrocyte deformability
    (Wiley, 2017) Kalayci, D.; Kucuk, A.; Sen, O.; Comu, F. M.; Arslan, M.; Unal, Y.
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