The effects of low and high doses of sugammadex on kidney tissue in streptozotocin-induced diabetic rats
Yükleniyor...
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Comenius Univ
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
BACKGROUND: Sugammadex is primarily excreted via renal route. We investigated effects of low and high doses of sugammadex (16 mg/kg versus 96 mg/kg) on renal tissue samples of streptozotocin-induced diabetic rats. MATERIAL AND METHODS: Twenty-four Wistar albino rats were divided into 4 groups. Group C (control - 0.9 % NaCl), Group DC (diabetes control; 55 mg/kg streptozotocin, IP, only), Group DR-16S (diabetes-rocuronium - 16 mg sugamnnadex, IV.) and Group DR-96S (diabetes- rocuronium - 96 mg sugammadex, IV). Renal tissue histopathological evaluation and antioxidant status (measurements of MDA levels and NO activities) were studied. RESULTS: Significantly higher levels of all inflammation parameters (inflammation, degeneration/necrosis, tubular dilatation, tubular cell degeneration, dilatation in Bowman's space, tubular hyaline casts, and lymphocyte infiltration) were found in the 96 mg/kg sugammadex group. Higher MDA tissue levels and lower NO activity were found in the 96 mg/kg sugammadex group. DISCUSSION: We can conclude that high-dose (96 mg/kg) sugammadex administration resulted in significant renal tissue damage in diabetic rats. As a consequence, low doses of sugamnnadex have to be preferred in diabetic patients (Tab. 2, Fig. 4, Ref. 26). Text in PDF www.elis.sk.
Açıklama
Arslan, Mustafa/0000-0003-4882-5063; Erdem, Ayhan/0000-0001-7761-1078; AYDIN, Muhammed Enes/0000-0001-8491-6566
Anahtar Kelimeler
sugammadex, streptozotocin, diabetes, renal damage
Kaynak
Bratislava Medical Journal-Bratislavske Lekarske Listy
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
116
Sayı
12
Künye
Kip, G., Turgut, H. C., Alkan, M., Aydin, M. E., Erbatur, M. E., Kiraz, H. A., Kartal, S., Boyunaga, H., Comu, F. M., Erdem, O., Arslan, M., & Unal, Y. (2015). The effects of low and high doses of sugammadex on kidney tissue in streptozotocin-induced diabetic rats. Bratislavske lekarske listy, 116(12), 746–750.
