The effects of low and high doses of sugammadex on kidney tissue in streptozotocin-induced diabetic rats
dc.contributor.author | Kip, G. | |
dc.contributor.author | Turgut, H. C. | |
dc.contributor.author | Alkan, M. | |
dc.contributor.author | Aydin, M. E. | |
dc.contributor.author | Erbatur, M. E. | |
dc.contributor.author | Kiraz, H. A. | |
dc.contributor.author | Unal, Y. | |
dc.date.accessioned | 2020-06-25T18:15:46Z | |
dc.date.available | 2020-06-25T18:15:46Z | |
dc.date.issued | 2015 | |
dc.department | Kırıkkale Üniversitesi | |
dc.description | Arslan, Mustafa/0000-0003-4882-5063; Erdem, Ayhan/0000-0001-7761-1078; AYDIN, Muhammed Enes/0000-0001-8491-6566 | |
dc.description.abstract | BACKGROUND: Sugammadex is primarily excreted via renal route. We investigated effects of low and high doses of sugammadex (16 mg/kg versus 96 mg/kg) on renal tissue samples of streptozotocin-induced diabetic rats. MATERIAL AND METHODS: Twenty-four Wistar albino rats were divided into 4 groups. Group C (control - 0.9 % NaCl), Group DC (diabetes control; 55 mg/kg streptozotocin, IP, only), Group DR-16S (diabetes-rocuronium - 16 mg sugamnnadex, IV.) and Group DR-96S (diabetes- rocuronium - 96 mg sugammadex, IV). Renal tissue histopathological evaluation and antioxidant status (measurements of MDA levels and NO activities) were studied. RESULTS: Significantly higher levels of all inflammation parameters (inflammation, degeneration/necrosis, tubular dilatation, tubular cell degeneration, dilatation in Bowman's space, tubular hyaline casts, and lymphocyte infiltration) were found in the 96 mg/kg sugammadex group. Higher MDA tissue levels and lower NO activity were found in the 96 mg/kg sugammadex group. DISCUSSION: We can conclude that high-dose (96 mg/kg) sugammadex administration resulted in significant renal tissue damage in diabetic rats. As a consequence, low doses of sugamnnadex have to be preferred in diabetic patients (Tab. 2, Fig. 4, Ref. 26). Text in PDF www.elis.sk. | en_US |
dc.identifier.citation | Kip, G., Turgut, H. C., Alkan, M., Aydin, M. E., Erbatur, M. E., Kiraz, H. A., Kartal, S., Boyunaga, H., Comu, F. M., Erdem, O., Arslan, M., & Unal, Y. (2015). The effects of low and high doses of sugammadex on kidney tissue in streptozotocin-induced diabetic rats. Bratislavske lekarske listy, 116(12), 746–750. | en_US |
dc.identifier.doi | 10.4149/BLL_2015_146 | |
dc.identifier.endpage | 750 | en_US |
dc.identifier.issn | 0006-9248 | |
dc.identifier.issn | 1336-0345 | |
dc.identifier.issue | 12 | en_US |
dc.identifier.pmid | 26924146 | |
dc.identifier.scopus | 2-s2.0-84973369159 | |
dc.identifier.scopusquality | Q2 | |
dc.identifier.startpage | 746 | en_US |
dc.identifier.uri | https://doi.org/10.4149/BLL_2015_146 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/6275 | |
dc.identifier.volume | 116 | en_US |
dc.identifier.wos | WOS:000367280800011 | |
dc.identifier.wosquality | Q4 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | |
dc.publisher | Comenius Univ | en_US |
dc.relation.ispartof | Bratislava Medical Journal-Bratislavske Lekarske Listy | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | sugammadex | en_US |
dc.subject | streptozotocin | en_US |
dc.subject | diabetes | en_US |
dc.subject | renal damage | en_US |
dc.title | The effects of low and high doses of sugammadex on kidney tissue in streptozotocin-induced diabetic rats | en_US |
dc.type | Article |
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