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    Azithromycin therapy of papillomatosis in dogs: a prospective, randomized, double-blinded, placebo-controlled clinical trial
    (Wiley-Blackwell, 2008) Yagci, Bugrahan Bekir; Ural, Kerem; Ocal, Naci; Haydardedeoglu, Ali Evren
    Azithromycin, an azalide subclass macrolide antibiotic, is an effective, well-tolerated and safe therapeutic option for treatment of papillomatosis in humans. This study reports the clinical and histopathological results from a prospective, randomized, double-blinded, placebo-controlled trial of 17 dogs of various breeds with diagnosis of oral (n = 12) and cutaneous papillomatosis (n = 5) treated with azithromycin. Papillomas appeared as whitish, verrucous, hyperkeratotic papules 1-2.7 mm in size. The cases were randomly assigned to azithromycin (n = 10) and placebo treatment groups (n = 7). Both owners and investigators were blinded to the allocation to the groups. Azithromycin (10 mg/kg) was administered per os every 24 h for 10 days. Clinical evaluations were done by the same investigator throughout the trial. Azithromycin treatment significantly decreased clinical scores (P < 0.001), whereas there was no change seen in the placebo group. In the azithromycin treatment group, skin lesions disappeared in 10-15 days. One case in the placebo had spontaneous regression of its papillomas by day 41, but lesions were still evident at day 50 in the remaining six cases. There was no recurrence of papillomatosis in the azithromycin treated dogs (follow up 8 months). No adverse effects were seen in either group. In conclusion, azithromycin appears to be a safe and effective treatment for canine papillomatosis.
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    Cardiac Troponin I Levels in Dogs with Dirofilariosis and without Dirofilariosis
    (Academic Journals Inc, 2011) Gazyagci, Serkal; Dogru, Mehmet Tolga; Yagci, Bugrahan Bekir
    Differences about Cardiac Troponin I (cTnI) levels between the dogs without dirofilariasis were investigated in this study. There were statistically significant differences about cTnI levels between the groups (For Group 1: 5.55 ng mL(-1) (2.1-10.0); for Group 2: 0.05 ng mL(-1) (0.03-0.06) p<0.001). As well as heart rate, respiration rate and temperature, cTnI levels were also found as statistically significantly important (p<0.001, p = 0.008 and p = 0.012, respectively). There was increased relative risk ratio for the body temperature group 2 (Relative risk ratio: 6.667 (2.827-15.724, Confidence interval: %95, p<0.001). There are statistically significant differences between the dogs with and without dirofilariasis about cTnI levels. It was speculated that cTnI level might be important indicator for evaluation of myocardial injury in the dogs with dirofilariasis.
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    Decreased Serum Adenosine Deaminase Activity Correlated with Clinical Score and Serum Proteins in Calves with Cryptosporidiosis
    (Zoological Soc Pakistan, 2016) Yarim, Gul Fatma; Yagci, Bugrahan Bekir; Ertekin, Ali; Kazak, Filiz
    This study was aimed to investigate serum adenosine deaminase (ADA) activity in calves with cryptosporidiosis. Significantly higher serum concentrations of globulin (P<0.01), blood urea nitrogen (P<0.01) and creatinine (P<0.01) were found and significantly lower albumin concentration (P<0.01) and albumin to globulin (A/G) ratio (P<0.001) in calves with cryptosporidiosis compared to healthy calves. Serum adenosine deaminase (ADA) activity was determined as 4.12+/-0.91 U/l; in calves with cryptosporidiosis compared to 10.27+/-1.71 U/l in healthy calves, which was significant at P<0.01 level. Serum ADA was negatively correlated with clinical score (P<0.05), which serum total protein concentration (P<0.05), serum globulin concentration (P<0.01) and serum A/G ratio (P<0.05) were positivity correlated in calves with cryptosporidiosis. From these results we concluded that cryptosporidiosis infection is closely related to low serum ADA activity which correlated with clinical score and serum total protein, globulin and A/G ratio in-calves. The results of the present study indicate possible role of ADA in development and progression of cryptosporidiosis.
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    An ectopic case of Psoroptes cuniculi infestation in a pet rabbit
    (Scientific Technical Research Council Turkey-Tubitak, 2007) Acar, Abuzer; Kurtdede, Arif; Ural, Kerem; Cingi, Cenker Cagri; Karakurum, Mehmet Cagri; Yagci, Bugrahan Bekir; Sari, Baris
    A 2-year-old female New Zealand rabbit was admitted to Ankara University Veterinary Faculty, Department of Internal Medicine. Upon physical examination crustaceous auricular lesions, and erythematous and exudative pruritic skin lesions, both on the ventral abdomen and on extremities were detected. Microscopic examination of skin scrapings taken from pinnae and hair plucked from the ventral abdominal region revealed the presence of Psoroptes cuniculi. The ventral abdominal localization of P. cuniculi was evaluated as an ectopic infestation. Despite the injection of ivermectin 400 mu g/kg and daily supportive therapy the rabbit died on the fifth day of hospitalization.
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    Endemic Contagious Agalactia in Sheep and Goats: Clinical Evaluation, Treatment and Vaccination
    (Medwell Online, 2010) Macun, Hasan Ceyhun; Ocal, Naci; Karahan, Murat; Yagci, Bugrahan Bekir; Kalender, Hakan; Kalin, Recep
    In this study, it aimed to evaluate clinical signs of Contagious Agalactia (CA) that had been affecting small ruminants in Kirikkale Province for 1.5 years and to intervene with this endemic CA by administration of enrofloxacin 5 mg kg(-1) for 5 days and a single dose of meloxicam (0.5 mg kg(-1)) to acutely infected animals and by vaccination of the flocks. The study was conducted between July 2007 and December 2008 on a total of 745 animals of 5 different flocks with problems of mastitis, keratoconjunctivitis and arthritis. Clinically determined CA was also confirmed by PCR analysis of milk samples. Arthritis was the most frequently observed clinical sign with a rate of 71.84% in diseased animals. Arthritis was observed either as a single problem or concurrently with mastitis or ocular lesions. The co-existence rate of ocular lesions with mastistis was 2.91% while observing all three lesions concomitantly was the least frequent, 2.91%. Ocular lesions alone was not seen in ewes and goats but co-existed with other signs. Ewes and goats exhibited a higher frequency of mastitis alone with a rate of 45 and 44.83%, respectively compared to other two clinical signs. The treatment protocol mentioned above was successful as the general body condition of the clinically diseased animals was improved and subsequently no incidence of death was observed. Animals gradually recovered from mastititis and conjunctivitis and the severity of keratoconjunctivitis and arthritis was decreased. It also concluded that application of a live CA vaccine twice with a 6 month-interval was quite effective as no case of CA was observed in vaccinated flocks during a 1 year follow-up period.