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    Cerebellum progesterone concentration decreased in canine distemper virus infection
    (Elsevier Sci Ltd, 2007) Yarim, Gül Fatma; Karahan, Siyami; Yarim, Murat
    Progesterone has neuroprotective effects including augmentation of myelination in the central and peripheral nervous system. This study was designed to determine if demyelinating lesions in the cerebellum resulting from canine distemper virus (CDV) infection are associated with progesterone levels. Progesterone was measured using radioinummoassay in samples of the cerebellum, corpus callosum, medulla oblongata, parietal, frontal, temporal, and occipital cortices as well as cerebrospinal fluid (CSF) and plasma collected from ten CDV infected and six non-infected dogs. The cerebellum progesterone level was significantly different between CDV infected (0.66 +/- 0.09 ng/g) and control dogs (1.14 +/- 0.09 ng/g) (p < 0.001); however, no difference was observed for the other CNS regions, plasma and CSF (p > 0.05). The cerebellum progesterone level was also significantly different between acute (0.71 +/- 0.05 ng/g) and chronic cases (0.61 +/- 0.09 ng/g) (p < 0.05). The CDV infected cerebella were also categorized histopathologically according to the severity of demyelinating lesions as mild (n = 5), moderate (n = 2), or severe (n = 3) among which the cerebellum progesterone level was significantly different (p < 0.05). Progesterone concentration was 0.71 +/- 0.05 ng/g in mild, 0.65 +/- 0.10 ng/g in moderate, and 0.56 +/- 0.07 ng/g in severe cases. In conclusion, progesterone concentration decreases in the cerebellum in CDV infection and the severity of demyelinating lesions is the greatest in cerebella with the lowest progesterone concentrations. The results suggest that local impairment of progesterone metabolism may be associated with the initiation and progression of cerebellar lesions in CDV infection. (c) 2006 Elsevier Ltd. All rights reserved.
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    Cystocaulus ocreatus infection in Anatolian wild sheep and dwarf goats
    (Scientific Technical Research Council Turkey-Tubitak, 2007) Kabakci, Nalan; Yildiz, Kader; Duru, Sibel Yasa; Yarim, Murat
    An Anatolian wild sheep (Ovis orientalis anatolica) from a wild ruminant farm near Kirikkale, Turkey, was necropsied. Parasitic nodules were situated beneath the pleura of the caudodorsal lobes of the lungs. First stage larvae of Cystocaulus ocreatus were detected both in bronchial fluid and in lung paraffin sections. Clinical and parasitological examinations of the other animals (4 dwarf goats and 3 wild sheep reared on the same farm) were also performed. First stage larvae of C. ocreatus, and eggs of Nematodirus spp. and Strongyloides spp. were observed in coproscopic examination. Anthelmintic treatment, Rabenzole (R) (rafoxanide and thiabendazole, Topkim), was administered to the animals infected by parasites. At the end of the treatment the combination of rafoxanide and thiabendazole was found to be markedly effective for the treatment of lungworm infection and no parasitic eggs were detected in the faeces of any of the treated animals.
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    Effects of amitraz plus-Parapoxvirus ovis on EGF, VEGF, IGF-1 and IGF-2 in canine generalized demodicosis
    (Univ Cordoba, 2022) Yarim, F. Gul; Pekmezci, Didem; Yarim, Murat; Yagci, B. Bugrahan; Gokceoglu, Ayris; Sozmen, Mahmut; Pekmezci, G. Zafer
    Objective. The purpose of the study is to investigate the effect of treatment with amitraz plus-Parapoxvirus ovis (IPPVO) on serum concentrations and skin expressions of insulin-like growth factor (IGF)-1 and -2, epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), in dogs suffering from generalised demodicosis (GD). Materials and Methods. GD affected dogs were injected 1 ml IPPVO on days 0, 2 and 9 subcutaneously in addition to amitraz (0.025%) treatment twice weekly for 80 days. IGF-1, IGF-2, EGF and VEGF concentrations in blood serum were measured by canine-specific enzyme-linked immunosorbent assay kit. EGF, VEGF, IGF-1, and IGF-2 expressions in skin biopsy specimens were examined immunohistochemically. Results. After the treatment of the dogs with amitraz plus-IPPVO in GD, we demonstrated a significant reduction in both circulating concentrations and skin expressions of EGF, VEGF, IGF-1, and IGF-2, which have a role in preserving skin integrity and wound healing. Conclusions. Results of this study suggest that IGF-1, IGF-2 EGF, and VEGF have a crucial role in the progression of GD in dogs. It is believed that the findings from this study will contribute to the development of new strategies for the treatment of GD, which is an important health problem for dogs.
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    Expression levels of angiogenic growth factors in feline squamous cell carcinoma
    (AKADEMIAI KIADO ZRT, 2020) Kabak, Yonca B.; Sozmen, Mahmut; Devrim, Alparslan K.; Sudagidan, Mert; Yildirim, Funda; Guvenc, Tolga; Yarim, Murat
    Squamous cell carcinoma (SCC) is the most common malignant neoplasm of the skin in cats. Tumour angiogenesis is the pivotal event for tumour progression and metastasis. We assessed protein and gene expression of angiogenic growth factors including bFGF, VEGF-C, TGF-beta, PDGF-A, PDGF-C and PDGFR-alpha that possibly contribute to the angiogenic phenotype of feline SCC (FSCC) and could, therefore, be a good target in the treatment of SCC. In the present study, a total of 27 FSCC cases were investigated. Tumour cases were histopathologically classified as well differentiated (10/27), moderately differentiated (5/27), and poorly differentiated (12/27). The expression levels of the growth factors were detected using immunohistochemistry and assessed semi-quantitatively. Growth factor expression levels were evaluated at different locations: in the oral region, in areas exposed to solar UV radiation including the ears, eyelids and nasal planum, and other miscellaneous locations. Our findings have revealed that FSCC arising from different anatomical sites of the body and showing differences in aggressiveness, metastasis, and prognosis may be angiogenesis dependent, and angiogenic key regulators could play a role in the development of FSCC.
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    THE MILK IGF-2 LEVEL IS POSITIVELY CORRELATED WITH MILK YIELD IN ANATOLIAN WATER BUFFALOES
    (Int Buffalo Information Ctr, 2023) Guler, Hakan; Yarim, Gul Fatma; Yarim, Murat; Duru, Ozkan; Gokceoglu, Ayris
    The aim of this study was to investigate the relationship between milk insulin-like growth factor-2 (IGF-2) concentration and milk yield in Anatolian water buffaloes. This study was conducted on milk samples from 80 Anatolian water buffaloes. Milk samples collected from buffaloes were evaluated for subclinical mastitis. For this purpose, the California mastitis test and somatic cell count were performed in milk samples taken from four different mammary lobes of buffaloes. The milk IGF-2 level was determined by an enzyme-linked immunosorbent assay kit. Milk IGF-2 concentration ranged from 21.6 ng/ml -63.2 ng/ml in Anatolian water buffaloes. The IGF-2 concentration in Anatolian water buffaloes milk was 40.1 & PLUSMN;8.5 ng/ml. Milk IGF-2 was positively correlated with milk yield (r2=0.941, P<0.01). Our results showed that milk IGF-2 concentration was associated with milk yield in Anatolian buffaloes. These findings show that locally synthesized IGF-2 can affect milk yield. This study contributes to the understanding of the composition of buffalo milk, which has an important value in human nutrition. It is recommended to confirm the results of similar measurements in milk from other animal species used for human consumption.