Expression levels of angiogenic growth factors in feline squamous cell carcinoma
Yükleniyor...
Dosyalar
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
AKADEMIAI KIADO ZRT
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Squamous cell carcinoma (SCC) is the most common malignant neoplasm of the skin in cats. Tumour angiogenesis is the pivotal event for tumour progression and metastasis. We assessed protein and gene expression of angiogenic growth factors including bFGF, VEGF-C, TGF-beta, PDGF-A, PDGF-C and PDGFR-alpha that possibly contribute to the angiogenic phenotype of feline SCC (FSCC) and could, therefore, be a good target in the treatment of SCC. In the present study, a total of 27 FSCC cases were investigated. Tumour cases were histopathologically classified as well differentiated (10/27), moderately differentiated (5/27), and poorly differentiated (12/27). The expression levels of the growth factors were detected using immunohistochemistry and assessed semi-quantitatively. Growth factor expression levels were evaluated at different locations: in the oral region, in areas exposed to solar UV radiation including the ears, eyelids and nasal planum, and other miscellaneous locations. Our findings have revealed that FSCC arising from different anatomical sites of the body and showing differences in aggressiveness, metastasis, and prognosis may be angiogenesis dependent, and angiogenic key regulators could play a role in the development of FSCC.
Açıklama
GULBAHAR, MUSTAFA YAVUZ/0000-0001-8268-7659
Anahtar Kelimeler
bFGF, feline, PDGF, squamous cell carcinoma, TGF beta 1, VEGF-C
Kaynak
ACTA VETERINARIA HUNGARICA
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
68
Sayı
1
Künye
Bu makale açık erişimli değildir.
