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Öğe Diagnosis of acute myeloid leukemia in a dental hospital; report of a case with severe gingival hypertrophy(Wolters Kluwer Medknow Publications, 2015) Misirlioglu, M.; Adisen, M. Z.; Yilmaz, S.Acute myeloid leukemias (AMLs) are aggressive hematopoietic neoplasms that, if untreated, can lead to death within days. Owing to its high morbidity rate, early diagnosis and appropriate medical therapy is essential. Oral lesions may be the presenting feature of acute leukemias and are, therefore, important diagnostic indicators of the disease. Erythematous or cyanotic gingival hyperplasia with or without necrosis is reported to be the most consistent symptom leading to a diagnosis of acute leukemia that directs the patient to seek early dental consultation. This report refers to a patient with AML that was provisionally diagnosed in the dental hospital due to severe gingival enlargements.Öğe The effect of 3 T MRI on microleakage of amalgam restorations(British Inst Radiology, 2013) Yilmaz, S.; Misirlioglu, M.Objectives: To evaluate the effects of 3 T magnetic field on microleakage of amalgam restorations containing three different types of silver (Ag). Methods: 60 extracted teeth were restored with three different types of amalgam filling materials. Restored teeth were sectioned mesiodistally and divided into experimental and control groups. Experimental groups were exposed to a magnetic field of 3 T for 20 min. All samples were plunged into 2% basic fuchsin solution and examined under a digital microscope by three different observers with regard to microleakage. Results: Statistical analysis showed significant differences in microleakage between the groups exposed to MRI and controls, whereas differences in microleakage between amalgam types were insignificant. Conclusions: The primary risk of MRI systems arises from the effects of its strong magnetic field on objects containing ferromagnetic materials. An MRI of 1.5 T is known to be safe for amalgam restorations. However, our research indicates that MRI is not completely devoid of any effects on amalgam restorations.Öğe Effect of bimatoprost on ocular circulation in patients with open-angle glaucoma or ocular hypertension(Springer, 2004) Akarsu, C.; Yilmaz, S.; Taner, P.; Ergin, A.Purpose: To study the effect of bimatoprost 0.03% (Lumigan) on ocular hemodynamics in patients with open-angle glaucoma or ocular hypertension. Methods: One randomly selected eye of each of 26 patients with open-angle glaucoma or ocular hypertension was enrolled. Each patient received a drop of bimatoprost 0.03% once daily for I month. The effect of bimatoprost on ocular circulation was assessed by color Doppler imaging (CDI), which measured peak systolic, end-diastolic blood flow velocities and resistance indices in the ophthalmic, posterior ciliary and central retinal arteries. Retrobulbar hemodynamics by CDI, intraocular pressure by Goldmann applanation tonometer, blood pressure by cuff, and heart rate by palpation were measured at baseline and at 1 month after bimatoprost treatment. Results: Blood flow velocities and resistance indices in all retrobulbar vessels showed no statistically significant differences between baseline and bimatoprost condition (P>0.05). Bimatoprost lowered intraocular pressure significantly (P<0.001), with a mean change of 6.5 mmHg (27%) after 1 month of treatment. The systolic (P=0.38) and diastolic (P=0.74) blood pressures and pulse rate (P=0.94) did not show statistically significant differences during the study period. Conclusions: The results of this study suggest that topical bimatoprost 0.03% significantly reduces intraocular pressure in patients with open-angle glaucoma or ocular hypertension. However, it does not have any effect on retrobulbar hemodynamics in open-angle glaucoma and ocular hypertension.Öğe Electrocatalytic Oxidation of Hydrazine on Poly(4-Aminobenzene Sulfonic Acid)-Modified Glassy Carbon Electrode (vol 52, pg 539, 2016)(Maik Nauka/Interperiodica/Springer, 2016) Sadikoglu, M.; Yilmaz, S.; Kurt, I.; Selvi, B.; Sari, H.; Erduran, N.; Saglikoglu, G.…Öğe Evaluation of gallbladder volume and motility in non-insulin-dependent diabetes mellitus patients using real-time ultrasonography(Lippincott Williams & Wilkins, 2003) Guliter, S.; Yilmaz, S.; Karakan, T.Aims: The prevalence of cholelithiasis is 2 to 3 times higher in patients with diabetes mellitus than in the normal population, especially in a group of patients with non-insulin-dependent diabetes mellitus (NIDDM). We investigated the pathogenesis of this increased prevalence by ultrasonography with a brief comparison of demographic features. Materials and Methods: The study group was consisted of NIDDM patients (41 males and 47 females, mean age 53.5 +/- 11 years), and the control group included healthy volunteers (33 males and 34 females, mean age 50.3 +/- 18 years). All patients were investigated after 12 hours of fasting and 30 minutes after a standard test meal. Pre-meal and post-meal gallbladder volumes were used for calculation of the ejection fraction of the gallbladder and fasting gallbladder volume. Results: In the study group, there was no correlation between the fasting gallbladder volume and age, parity, and body mass index. However, fasting gallbladder volume and duration of diabetes mellitus showed significant correlation (r = 0.212, P < 0.05). The mean ejection fraction of gallbladders in the study group was 48.48%, whereas that of the control group was 56.32%. There was a significant reduction of ejection fraction in the study group (P = 0.003). Conclusion: Our study indicated that there were an increased fasting gallbladder volume and impaired ejection fraction in NIDDM patients. This may be the initiator of bile stasis in the gallbladder and subsequent cholesterol crystal and stone formation.Öğe Factors contributing to sex assignment and reassignment decisions in Turkish children with 46,XY disorders of sex development(Freund Publishing House Ltd, 2007) Uslu, R.; Öztop, D.; Özcan, O. e.; Yilmaz, S.; Berberoglu, M.; Adiyaman, P.; Öcal, G.Background. Sex assignment decisions for children with disorders of sex development (DSD) should be based on integrative assessments of relevant biological and psychosocial characteristics. Aim: To investigate the factors that contributed to sex assignment decisions for children with 46,XY DSD. Patients: Sixty-one children recruited from a clinical sample were evaluated. Methods: Findings of endocrinological and psychiatric evaluations were entered into a logistic regression analysis. Results: Gender identity was the strongest correlate of assigned sex. External genital under-virilization, sex announced at birth and toy/ activity preferences were predominant predictors. Twelve children, six of whom were prepubertal, were reassigned to male sex. Conclusions: Psychological factors seem to be as influential on sex reassignment decisions as are endocrinological and social factors, especially if the disorder is diagnosed at an older age. Prepubertal gender conversion is possible, which implies the importance of follow-up during childhood.Öğe Perception of bronchoconstriction in obstructive pulmonary diseases (disease-specific dyspnoea)(Portland Press Ltd, 2003) Ekici, A.; Yilmaz, S.; Ekici, M.; Kalpaklioglu, F.; Karadeniz, Y.; Arslan, M.; Kurtipek, E.The perception of dyspnoea differs between subjects with obstructive pulmonary diseases, partly because the underlying mechanisms for bronchoconstriction are different. We investigated the perception of bronchoconstriction in subjects with bronchiectasis, asthma and chronic bronchitis and possible contributing factors. Forty-seven non-smoking subjects with bronchiectasis, 50 subjects with asthma and 31 with chronic bronchitis were challenged with histamine. The Borg score was assessed before and after each challenge. The perception score corresponding to a fall in the forced expiratory volume in 1 s (FEV1)by 20% (PS20) was calculated. The mean values of DeltaBorg/DeltaFEV(1), (the Borg score change divided by the change in FEV1 as a percentage of the baseline FEV1) and PS20 of subjects with bronchiectasis and chronic bronchitis were significantly lower than in subjects with asthma after histamine challenge. The ratio of non-perceivers was higher in bronchiectasis (25.5%) and in chronic bronchitis (32.3%) than in asthma (4.0%). When all subjects were considered, DeltaBorg/DeltaFEV, values were significantly related to female sex(r(2)=11.5%, P=0.0001), but not to age, duration of the disease, PD20 or baseline FEV1%. The present study indicates that perception of histamine-induced bronchoconstriction is lower in patients with bronchiectasis and chronic bronchitis than in asthmatic patients, and that sex partially contributes to this difference.Öğe Primary hydatid cyst in the retroperitoneal space: role of CT(Springer, 2002) Yilmaz, S.; Baydar, S.; Guney, S.; Hoser, A.; Celik, B.Localization of hydatid disease in the retroperitoneal space is extremely rare. We present the CT findings in a patient with echinococcal disease (E. Granulosus) in whom the cyst was localized to the retroperitoneum.Öğe Smoking prevents the expected postprandial increase in intestinal blood flow - A Doppler sonographic study(Amer Inst Ultrasound Medicine, 2004) Ünal, B.; Bilgili, M.Y.K.; Yilmaz, S.; Caglayan, O.; Kara, S.Objective. To assess whether cigarette smoking had an effect on superior mesenteric artery postprandial blood flow. Methods. Forty-six subjects were studied in 3 groups with Doppler sonography. Group A consisted of nonsmokers; groups B and C consisted of smokers. In group B, subjects were allowed to smoke cigarettes postprandially, whereas in group C, postprandial smoking was prohibited. A baseline Doppler evaluation was performed in the fasting state, and consecutive Doppler evaluations were performed postprandially with 30-min intervals for 120 minutes. Doppler sonographic measurements of the superior mesenteric artery including peak systolic and end-diastolic velocities, resistive index, and diameter, were calculated. Statistical analysis was performed by analysis of variance. Results. All groups showed significant changes with time for all parameters (P < .001 for all). The changes in time were significantly different at 90 and 120 minutes for peak systolic velocity, at 90 minutes for end-diastolic velocity, and at 120 minutes for diameter between groups. Group B had the greatest differences. Compared with group A, changes in peak systolic velocity at 90 to 120 minutes were significantly lower in group B (P = .007 and .006, respectively), and compared with groups A and C, changes in end-diastolic velocity at 90 minutes (P = .006 and .004, respectively) and diameter at 120 minutes (P = .007 and .011, respectively) were significantly lower in group B. Conclusions. Smoking immediately after meals was associated with a superior mesenteric artery blood flow increase that was lower than expected, which may explain the belief that smoking reduces body weight. Postprandial smoking may have undesired results in patients with chronic intestinal ischemia.Öğe The efficacy of platelet-rich plasma gel in MRSA-related surgical wound infection treatment: an experimental study in an animal model(Springer Heidelberg, 2018) Cetinkaya, R. A.; Yilmaz, S.; Unlu, A.; Petrone, P.; Marini, C.; Karabulut, E.; Urkan, M.IntroductionThe wound healing properties of platelet-rich plasma (PRP) gel have been documented in many studies. PRP gel has also become a promising agent for treating surgical site infections. In this study, we investigated the antibacterial activity and wound healing effectiveness of PRP in an animal model of Methicillin-resistant Staphylococcus aureus subsp. aureus (MRSA N315)-contaminated superficial soft tissue wounds.Materials and methodsSubcutaneous wounds in Wistar Albino male rats were created by making two cm midline incisions followed by inoculation of microorganisms. Study groups comprised of Sham (no treatment), PRP alone, MRSA alone, MRSA+PRP, MRSA+Vancomycin, and MRSA+Vancomycin+PRP groups. We inoculated 0.1mL (3x10(8) CFU/mL) of MRSA in contaminated groups. After 8 days, all rats were killed, wounds were excised and subjected to histopathologic examination, and MRSA counts were determined.ResultsMRSA counts in MRSA, MRSA+PRP, MRSA+Vancomycin and MRSA+Vancomycin+PRP groups were 5.1x10(6) (SD0.4) CFU/mL, 4.3x10(6) (SD +/- 0.7) CFU/mL, 2.3x10(6) (SD +/- 0.3) CFU/mL, 1.1x10(6) (SD +/- 0.4) CFU/mL, respectively. The inflammation scores of MRSA+PRP, MRSA+Vancomycin, and MRSA+Vancomycin+PRP groups were significantly lower than the MRSA group. MRSA+Vancomycin+PRP group inflammation score was significantly lower than the MRSA+PRP group.DiscussionAll treatment groups were effective in wound healing and decreasing the MRSA counts. MRSA+PRP combined created identical inflammation scores to the PRP group. More in vivo studies are required to corroborate these findings.Öğe The Safety of High-Field MRI?(Natl Iranian Oil Co-Nioc Polyclinics, 2014) Yilmaz, S.[Abstract No tAvailable]Öğe To see bruxism: a functional MRI study(British Inst Radiology, 2015) Yilmaz, S.Objective: Since the pathophysiology of bruxism is not clearly understood, there exists no possible treatment. The aim of this study is to investigate the cerebral activation differences between healthy subjects and patients with bruxism on behalf of possible aetiological factors. Methods: 12 healthy subjects and 12 patients with bruxism, a total of 24 right-handed female subjects (aged 20-27 years) were examined using functional MRI during tooth-clenching and resting tasks. Imaging was performed with 3.0-T MRI scanner with a 32-channel head coil. Differences in regional brain activity between patients with bruxism and healthy subjects (control group) were observed with BrainVoyager QX 2.8 (Brain Innovation, Maastricht, Netherlands) statistical data analysis program. Activation maps were created using the general linear model: single study and multistudy multisubject for statistical group analysis. This protocol was approved by the ethics committee of medical faculty of Kirikkale University, Turkey (02/04), based on the guidelines set forth in the Declaration of Helsinki. Results: The group analysis revealed a statistically significant increase in blood oxygenation level-dependent signal of three clusters in the control group (p < 0.005), which may indicate brain regions related with somatognosis, repetitive passive motion, proprioception and tactile perception. These areas coincide with Brodmann areas 7, 31, 39 and 40. It is conceivable that there are differences between healthy subjects and patients with bruxism. Conclusions: Our findings indicate that there was a decrease of cortical activation pattern in patients with bruxism in clenching tasks. This indicates decreased blood flow and activation in regional neuronal activity. Bruxism, as an oral motor disorder concerns dentistry, neurology and psychiatry. These results might improve the understanding and physiological handling of sleep bruxism.