Perception of bronchoconstriction in obstructive pulmonary diseases (disease-specific dyspnoea)
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Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Portland Press Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The perception of dyspnoea differs between subjects with obstructive pulmonary diseases, partly because the underlying mechanisms for bronchoconstriction are different. We investigated the perception of bronchoconstriction in subjects with bronchiectasis, asthma and chronic bronchitis and possible contributing factors. Forty-seven non-smoking subjects with bronchiectasis, 50 subjects with asthma and 31 with chronic bronchitis were challenged with histamine. The Borg score was assessed before and after each challenge. The perception score corresponding to a fall in the forced expiratory volume in 1 s (FEV1)by 20% (PS20) was calculated. The mean values of DeltaBorg/DeltaFEV(1), (the Borg score change divided by the change in FEV1 as a percentage of the baseline FEV1) and PS20 of subjects with bronchiectasis and chronic bronchitis were significantly lower than in subjects with asthma after histamine challenge. The ratio of non-perceivers was higher in bronchiectasis (25.5%) and in chronic bronchitis (32.3%) than in asthma (4.0%). When all subjects were considered, DeltaBorg/DeltaFEV, values were significantly related to female sex(r(2)=11.5%, P=0.0001), but not to age, duration of the disease, PD20 or baseline FEV1%. The present study indicates that perception of histamine-induced bronchoconstriction is lower in patients with bronchiectasis and chronic bronchitis than in asthmatic patients, and that sex partially contributes to this difference.
Açıklama
Ekici, Arif B/0000-0001-6099-7066;
Anahtar Kelimeler
asthma, bronchiectasis, chronic bronchitis, dyspnoea, perception
Kaynak
Clinical Science
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
105
Sayı
2
Künye
closedAccess
