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    Are the correlation results of HPV positive cases with cervical smear always consistent?
    (2023) Zergeroğlu, Sema; Özkan, Zehra Sema; Aydın, Arzu Hazal
    Aim: Cervical cancer is a type of genital cancer which come second after breast cancer in women and may cause death. However, it can be prevented with screening tests by ensuring early diagnosis. Most of cervical cancers (99.7%) are associated with Human Papilloma Virus (HPV) and it is known that HPV must be present for the generation of cervical cancer. Thus, 70% of the patients have been found to be positive for HPV-16 and HPV-18. Both the association with cervical cancer and HPV and data related to development of cancer and dysplasia was researched retrospectively in this study. It was aimed to analyze and use the results by examine if the smear results of the patients and the HPV results are compatible in all HPV positive cases. Material and Method: 1050 patients who were examined by gynecologist and taken Pap smear test at the end of the examination during July 2020 and March 2022, were included in our study. In all cases the Pap test was re-evaluated by the same pathologist using the 2014 Bethesda System. High-risk HPV (HR HPV) DNA (HPV types 16,18,31,33,35,39,45,51,52,56,58,59,66,68) tests results, applied to the patients at an external center, were reviewed. Results of patients diagnosed as LSIL, HSIL and cervical cancer by Pap smear test were evaluated again beside HPV DNA analyses and their clinical information. Chi-square test was used for statistical analysis. p
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    Öğe
    The relationship between body-mass index and Helicobacter pylori infection: a case-control study
    (2021) Benek, Suat; Zengin, Mehmet; Zergeroğlu, Sema; Baydar, Ahmet; Sevmiş, Murat
    Objective: Helicobacter pylori infection is one of the most common infections worldwide. There are different opinions in the literature about\rthe relationship between H. pylori and obesity. In this study, we investigated the relationship between body-mass index (BMI) and H. pylori\rinfection.\rMaterial and Method: A cross-sectional study was conducted among patients who underwent endoscopic examinations at Tekirdağ Namık\rKemal University Faculty of Medicine Hospital in 2019. The prevalence of H. pylori infection was examined by biopsy. The relationship\rbetween BMI and H. pylori infection was analyzed.\rResults: 51.8% of the cases in our population were positive for H. pylori infection. On histopathological examination, acute and chronic\rinflammation findings were higher in H. pylori-positive cases compared to H. pylori-negative cases. The prevalence of H. pylori infection\rwas higher in patients with high BMI than those with low BMI. Statistical analysis showed a significant relationship between BMI and the\rprevalence of H. pylori infection (p<0.001), and there was a positive linear correlation between these two parameters (r=0.542). When the\rrisk factors were examined univariable, BMI was found to be a significant risk factor for H. pylori infection (p=0.008). Multivariable analysis\rresults revealed that BMI is an independent risk factor for H. pylori infection. (OR=1.32 (1.09-3.46), p=0.025).\rConclusion: Our results showed that there is a significant relationship between BMI and H. pylori infection, and high BMI is an independent\rrisk factor for H. pylori infection.