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Öğe Therapeutic effect of some natural active compounds for breast cancer(Humana Press Inc, 2022) Gökalp, FaikThe extracts obtained from plants have been used in the treatment of many diseases since the earliest times. Today, it is of great importance to investigate the effects of the active molecules in these plant extracts at the molecular level together with the analysis. The effect of certain active compounds found in some plants, widely used as medicinal plants, on breast cancer has been investigated using docking. As a result of the docking scores obtained, it can be understood that the active molecules used in this study can be quite effective in controlling breast cancer. Promyelocytic leukemia is an important checkpoint from the literature for breast cancer and the docking energy values of Thymoquinone, Piperine and Carvacrol, as the active molecules in the control of this pathway. This study is very important when evaluated in terms of directing experimental studies by determining the most suitable active substances by comparing the activities of molecules in a short time.Öğe The highly protective natural medical agents against COVID-19(Aepress Sro, 2021) Gökalp, Faik; Sayın, K.OBJECTIVE: The studies to prevent the Corona virus, which is a huge epidemic nowadays and causes the death of many people, are of great importance. Drugs to be developed to prevent the proliferation and spread of it. The active substances of the drugs have been used to prevent the attack of the COVID-19. The natural phytochemicals obtained from the traditional medicine play a big role in the inhibition of functional structures in many harmful microscopic structures. METHODS: The active role of the substances for protecting from the attack of COVID-19 have been calculated and determined by using docking. RESULTS: It has been clarified that drug active substances inhibit COVID-19. The selected active ingredients seem to have considerable inhibition effects for COVID-19. Molecular mechanical Poisson-Boltzman (MM-PSBA) calculations were used to analyse the selected molecules. CONCLUSION: This study is the first in terms of reducing the harmful effect of COVID-19 by providing effective results in a short time by guiding the experimental studies to reveal the inhibitory effect of COVID-19 Ref. Text in PDF www.elis.skÖğe The effects of perceived parental math support on middle school students' math engagement: the serial multiple mediation of math self-efficacy and math enjoyment(Springer, 2022) Sağkal, Ali Serdar; Sönmez, Melike TuralThe present study explored the direct and indirect (serial multiple mediation of math self-efficacy and math enjoyment) effects of perceived parental math support on middle school students' math engagement. A total of 374 middle school students ranging the age of 11 to 15 years completed a set of questionnaires assessing perceived parental math support, math self-efficacy, math enjoyment, and math engagement. In the analysis of structural model, a multiple-step multiple mediation analysis was employed. The findings indicated that perceived parental math support was directly and positively associated with math engagement. Additionally, math self-efficacy and math enjoyment sequentially mediated the relationship between parental math support and math engagement. The limitations and implications of the results are discussed and suggestions for future research are proposed.Öğe The effective natural compounds for inhibiting Cervical cancer(Humana Press Inc, 2021) Gökalp, FaikThe secondary compounds found in plants are of great importance in the treatment of many diseases in medicine and pharmacy. Some of these compounds have been reported to exhibit anticarcinogenic effects by inhibiting the growth and metastatic potential of cancer cells. Consumption of the required amount of vegetables and fruits appears to have a protective effect of these secondary compounds on cancer, since most of these drugs are synthesized from natural or natural origin compounds. Secondary compounds in medicinal plants have been found to have an antiproliferative effect by increasing the expression of p53 in cervical cancer cells and decreasing the expression of cyclin D1, one of the cell proliferation markers. The most important step in the fight against cancer is the development of drugs that are selectively targeted against tumor cells and targeting cancer cells to reduce damage to normal cells and prevent the growth and spread of cancer cells. Molecular insertion test is an effective tool for evaluating the bioactivity of possible molecules. In this study, the effect of natural compounds in some medicinal plants in inhibiting cervical cancer, the points where they are effective using docking has been investigated.Öğe The effect of cluster teaching with worksheets on students’ academic achievement in distance education(Anadolu Univ, 2022) Çelik, Elif; Özdemir Baki, Gülşah; Işık, AhmetThe aim of this study is to examine the effect of teaching with worksheets prepared for the 6th grade clusters in distance education on the academic achievement of students. The research was conducted with 39 students studying in a public secondary school in eastern Turkiye in the first semester of the 2020-2021 academic year. In the study, a quasi-experimental design with pretest-posttest control group was practiced to collect data. In the experimental group, the subject of cluster was taught with worksheets prepared in accordance with the constructivist teaching, and in the control group, with general teaching methods. After the practice, the Clusters Achievement Test was applied to the experimental and control group students as pre-test and post-test. The academic achievement of the experimental and control groups were compared and it was determined that there was a statistically significant difference in favor of the experimental group. Data analyzes showed that the worksheets prepared for the subject of clusters in distance education increased the academic achievement of the students. At the end of the practice carried out within the scope of the study, semi-structured interviews were conducted with 5 students in the experimental group who fully participated in the studies and activities. The findings obtained from the interviews showed that the students adopted the lessons taught with the worksheets. In addition, it was determined from the statements of the students that they were satisfied with the teaching of the lessons using worksheets in the distance education process, they participated more actively in the online lessons, and they made extra efforts in using materials and completing the activities.Öğe The curative effect of some natural active compounds for liver cancer(Humana Press Inc, 2022) Gökalp, FaikCancer is a disease that has become widespread recently and has been studied extensively. It is of great importance to find an active and effective treatment quickly due to the emergence of the disease and its spread to many tissues in the organism by metastasis. In this study, it is aimed to detect active and active substances that are highly effective on cancer cells in a short time by using docking scores, the accuracy of which has been proven by many studies. Today, many medicinal plants are being studied for therapeutic purposes. In this study, the activities of the prominent active substances in these medicinal plants were compared with the docking scores and the molecules with the highest inhibition effect on liver cancer receptors were determined. The data obtained in this study are of great importance in terms of guiding experimental studies by detecting active substances effective on liver cancer by preventing time and material loss. Considering the results obtained from this study, it can be concluded that Cucurbitacin I and Cucurbitacin E, Thymol, Piperine, and Carvacrol are very effective for the inhibition of liver cancer cell receptors.Öğe Teacher candidates' proficiency in utilising the REACT strategy through experimental activities(Inderscience Enterprises Ltd, 2023) Çelik, Harun; Pektaş, Hüseyin Miraç; Karaşahin, Abdulsamet; Karamustafaoğlu, OrhanIt is known that the success of a science education reform depends considerably on science teachers' knowledge, skills and activities. In accordance with this, the aim of this study is to investigate the proficiency of science teacher candidates in the use of the REACT strategy through their experimental science activities within the scope of context-based learning approach. Within this context, this study was designed in the form of a longitudinal analysis, performances were analysed periodically, and the transformation was pursued. The data obtained from documents by means of a content analysis was presented via graphical instruments through converting it into quantitative data by means of the rubric which was developed by the researchers. According to the longitudinal analysis findings, it was observed that the teacher candidates' performance in utilising the REACT strategy is parallel to the ascending number of activities.Öğe Synthesis, spectroscopic characterizations, single crystal XRD, supramolecular assembly inspection via hirshfeld surface analysis, and DFT study of a hydroxy functionalized schiff base Cu(II) complex(Elsevier, 2024) İnaç, Hasan; Ashfaq, Muhammad; Dege, Necmi; Feizi-dehnayebi, Mehran; Munawar, Khurram Shahzad; Yağ, Nermin Kahveci; Poyraz, Cinar EmineThe current work describes the synthesis, characterization, and theoretical investigation of a copper complex with a hydroxy functionalized Schiff base ligand. The complex [Cu(DHBEE)(2)] was characterized by UV-Visible, FT-IR, and mass spectrometry. The crystalline nature of [Cu(DHBEE)(2)] was examined using X-ray diffraction (XRD), revealing that the Cu2+ ion occupies a center of inversion symmetry and adopts a square planar geometry. The supramolecular assembly was stabilized by non-covalent interactions, which were further probed by Hirshfeld surface analysis along with the computation of energy of interaction between the molecular pairs and energy frameworks. Void analysis was carried out to check whether large cavities were present in the crystal or not. Density functional theory utilizing the B3LYP/LANL2DZ/6-311 G (d) level of theory indicates that the calculated bond lengths and bond angles of [Cu(DHBEE)(2)] support X-ray data. The O4 and O4(i) atoms are the sites for electrophilic attack due to the obtained results from the MEP map, Mulliken atomic charge, and Fukui function. Furthermore, HOMO-LUMO analysis verifies the enhanced chemical reactivity of the complex as compared to the ligand. The value of the energy gap for complex and ligand displays that the order of charge transfer rises as follows: [Cu(DHBEE)(2)] > (DHBEE).Öğe Synthesis and spectral properties of symmetrically arylated BODIPY dyes: Experimental and computational approach(Elsevier, 2023) Yilmaz, Rasit Fikret; Derin, Yavuz; Mısır, Büşra Albayrak; Atalay, Vildan Enisoglu; Tutar, Ömer Faruk; Ökten, Salih; Tutar, AhmetIn this study, a series of symmetrically arylated BODIPY dyes were synthesized using a pre-functionalization method, and their structures were characterized by several spectroscopic methods. The relationship between the aryl substitution pattern and the photophysical and electrochemical properties of the dyes was investigated using experimental and computational methods. It was found that electron-donating & pi;-conjugated groups at the meso position and electron-accepting & pi;-conjugated groups at the C3/C5 position led to blue-shifted spectra, while the opposite substitution pattern resulted in red-shifted spectra. Additionally, inductive electron-donating alkyl groups at the meso position produced a blue spectral shift and an alkyl group at the meso position significantly increased the fluorescence quantum yield compared to the arylated counterparts. Computational investigations revealed that a thioanisyl group at the C3/C5 position resulted in a significantly narrow band gap. These results provide valuable insights into the design and development of new BODIPY dyes with tailored properties for various applications.Öğe Structural Investigation and Hirshfeld Surface Analysis of 2-6-Dimethoxy-4-((2-Nitrophenylimin)Methyl)Phenol(Bentham Science Publ Ltd, 2024) İnaç, HasanIntroduction The reaction between 4-hydroxy-3,5-dimethoxyenzaldehyde and 2-ni-troaniline has been discovered, and the final product has been identified such as 2-6-dimethoxy-4-((2-nitrophenylimin)methyl)phenol (C1).Materials and Methods X-ray diffraction examination per-formed on a single crystal provided conclusive evidence regarding the structure. Crystallography reveals that the two molecules A and B that were enclosed within the asymmetric unit are struc-turally distinct from one another. C-HO, N-HO, and O-HO bonding is primarily respon-sible for the crystal packing stability. H-O and off-set stacking interactions also contribute to the crystal packing's overall stability.Results To do further research into the intermolecular interactions, the Hirshfeld surface analysis technique is utilized. It is possible to determine the partiality of the interatomic contacts to create crystal packing interactions by computing the improvement ratio for those contacts. In addition, computational research is carried out with the B3LYP/6-31G(d,p) model to determine the amount of energy that is required for molecular pairs to interact.Conclusion The study concluded the roles those different kinds of interaction energy play in maintaining the stability of the molecular pair.Öğe STEM professional development program for gifted education teachers: STEM lesson plan design competence, self-efficacy, computational thinking and entrepreneurial skills(Elsevier Sci Ltd, 2024) Şahin, Erhan; Sarı, Uğur; Şen, Ömer FarukThis study examined the impact of a 10-month STEM professional development (PD) program on 25 teachers working with gifted students. The program aimed to enhance pedagogical knowledge and competencies. Findings indicated significant positive improvements in teachers' STEM selfefficacy, computational thinking, and entrepreneurship skills. The PD program also had a direct positive influence on the quality of lesson plans. The study suggests that effective PD design should incorporate scientific inquiry, engineering design processes, computational thinking, entrepreneurship skills, and the development of teachers' self-efficacy for successful implementation of PD outcomes in STEM education.Öğe Production and characterization of fruit jam with activated pectin using wild hawthorn puree (Crataegus monogyna Jacq.)(Taylor & Francis Ltd, 2023) Farzaliev, Elsevar Babaoglu; Ökten, SalihIn this study, we developed a technology for the production of jelly confiture based on natural hawthorn puree. The use of activated low-esterified hawthorn pectin in the recipe was shown to increase the complexing ability of the product in relation to zinc and lead ions, making it suitable for functional preventive nutrition. The final product was characterised by a bright orange-yellow colour, a distinct hawthorn taste and odour, and a gelatinous consistency. Evaluation of the product based on organoleptic, physicochemical, and microbiological indicators showed that it had high nutritional and physiological value due to its retention of native micronutrients, high content of potassium, magnesium, and calcium, and antioxidant activity. The use of this product in a daily diet can satisfy the daily need for physiologically active substances and food ingredients. Overall, the use of natural puree from wild hawthorn fruit in the technology of jelly confiture allows for the expansion of raw material sources in the production of confectionery products with high nutritional and physiological value. [GRAPHICS]Öğe Problem Posing Via Scriptwriting: What Instructional Flows Do Mathematics Teachers Use in Implementing the Problem-Posing Task?(Springer, 2024) Kar, Tuğrul; Öztürk, Ferhat; Öcal, Mehmet Fatih; Özkaya, MerveThe present study aimed to describe teachers' instructional flows when implementing a mathematical problem-posing task using scriptwriting technique. With matchsticks, a growing pattern that increases by a constant unit was created and presented to the teachers as a problem-posing situation. We analyzed the instructional flows in 50 scripts, taking into account situations recognized in the problem-posing field as critical for integrating problem posing into mathematics classrooms. We determined three instructional flows in the scripts: pose and solve cycle-based, observation-based, and problem-solving based, the first being the most common. We presented a new problem-posing instructional model and discussed its potential benefits for student learning.Öğe Pre-service elementary teachers' noticing expertise of students' mathematical thinking: the case of fractions(Taylor & Francis Ltd, 2023) Coşkun, Sümeyra Doğan; Sitrava, Reyhan Tekin; Bostan, Mine IsiksalThe purpose of the study is to investigate pre-service elementary teachers' noticing expertise of students' mathematical thinking within the context of fractions. For this purpose, 32 pre-service elementary teachers were asked to examine students' answers and ways of thinking given in written excerpts related to fractions. The data was mainly analysed using the constant comparative method to identify similarities and differences in pre-service elementary teachers' answers based on the existing Professional Noticing of Children's Mathematical Thinking framework developed by Jacobs, Lamb, and Philipp ([2010]. Professional noticing of children's mathematical thinking. Journal for Research in Mathematics Education, 41(2), 169-202.). The findings indicated that the vast majority of the pre-service elementary teachers showed at least a limited level in all professional noticing skills: attending, interpreting, and deciding how to respond. The findings serve to inform teacher educators to include written excerpts in their mathematics teaching courses and, thus result in improvement in pre-service teachers' noticing skills.Öğe Pose, solve and pose cycle: an examination on the change of pre-service mathematics teachers' problem-posing performances(Oxford Univ Press, 2024) Kar, Tuğrul; Öztürk, Ferhat; Özkaya, MerveWe designed a programme consisting of initial problem posing related to a problem about oil drums, teaching activities to solve the problem and further problem posing to investigate the change in pre-service mathematics teachers' problem-posing performances and the potential role of teaching activities in these performances. The participants' problem-posing fluency and flexibility scores showed statistically significant improvement over the course of the cycle. Although there was an improvement in problem-posing rarity scores, it was not statistically significant. Understanding the visual model and discovering the geometric properties of the problem were identified as categories that were effective in improving the participants' performances.Öğe Nurturing prospective teachers noticing skills through argumentation: The case of fractions(Elsevier Sci Ltd, 2024) Işıkal-Bostan, Mine; Çatman-Aksoy, Emine; Tekin-Sitrava, ReyhanThis study aimed to investigate the extent to which prospective teachers' noticing skills develop while they engage in argumentation on students' mathematical thinking regarding fractions. The study consisted of 10 third-year prospective teachers participating in online methods of teaching mathematics course. Classroom teaching experiment design was used where 8 sessions of teaching experiments were conducted. Data involved pre and post-tests, interviews, video recordings, daily reports, and post-discussion reflection papers. Findings revealed that prospective teachers' noticing skills of attending to students' strategies and making sense of their understanding were enhanced after their involvement in the classroom teaching experiment. Findings were discussed within the scope of the noticing literature.Öğe Novel methoxyquinoline derivative: Synthesis, characterization, crystal structure, Hirshfeld surface, thermodynamic properties, and quantum chemical calculation of 3,6,8-trimethoxyquinoline(Taylor & Francis Ltd, 2021) Ökten, Salih; Demircioğlu, Zeynep; Erşanlı, Cem Cüneyt; Çakmak, OsmanIn this study, we describe the synthesis and structural characterization of novel 3,6,8-trimethoxyquinoline (2) by X-ray, FT-IR, NMR analysis, and its computational investigations. The molecular geometry of title coumpound was also optimized by using density functional theory (DFT/B3LYP) and Hartree-Fock (HF) methods with the 6-311 G(d,p) basis set, and geometric parameters were compared with the experimental data. Theoretical calculations are a good way for obtaining comprehensive information about global and local chemical activity, and chemical and molecular properties that reveal the nucleophilic and electrophilic nature. Molecular electrostatic potential (MEP) distribution, thermodynamic parameters, frontier molecular orbitals (FMOs), Fukui functions, and net charge analysis of (2) were also investigated. Also, the interactions between the molecule with DNA bases such as guanine, adenine, thymine, and cytosine were investigated by using the electrophilicity-based charge transfer (ECT) method and charge transfer (Delta N) for investigating the charge transfer, electrophilic, and nucleophilic nature.Öğe Novel diarylated tacrine derivatives: Synthesis, characterization, anticancer, antiepileptic, antibacterial, and antifungal activities(Wiley, 2024) Mısır, Büşra A.; Derin, Yavuz; Ökten, Salih; Aydın, Ali; Koçyiğit, Ümit M.; Şahin, Hatice; Tutar, AhmetIn this study, our goal was to synthesize novel aryl tacrine derivatives and assess their potential as anticancer, antibacterial agents, and enzyme inhibitors. We adopted a two-step approach, initiating with the synthesis of dibromotacrine derivatives 3 and 4 through the Friedlander reaction. These intermediates underwent further transformation into diarylated tacrine derivatives 3a-e and 4a-e using a Suzuki-Miyaura cross-coupling reaction. Thorough characterization of these novel diarylated tacrines was achieved using various spectroscopic techniques. Our findings highlighted the potent anticancer effects of these innovative compounds across a range of cancer cell lines, including lung, gynecologic, bone, colon, and breast cancers, while demonstrating low cytotoxicity against normal cells. Notably, these compounds surpassed the control drug, 5-Fluorouracil, in terms of antiproliferative activity in numerous cancer cell lines. Moreover, our investigation included an analysis of the inhibitory properties of these novel compounds against various microorganisms and cytosolic carbonic anhydrase enzymes. The results suggest their potential for further exploration as cancer-specific, enzyme inhibitory, and antibacterial therapeutic agents. Notably, four compounds, namely, 5,7-bis(4-(methylthio)phenyl)tacrine (3d), 5,7-bis(4-(trifluoromethoxy)phenyl)tacrine (3e), 2,4-bis(4-(trifluoromethoxy)phenyl)-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-amine (4e), and 6,8-dibromotacrine (3), emerged as the most promising candidates for preclinical studies. The novel aryl substituted tacrine were efficiently synthesized and their anticancer potentials were highlighted in this study. Their inducing apoptosis, cell migration, and mitochondrial membrane potentials were screened. imageÖğe Biological activity and molecular docking studies of some new quinolines as potent anticancer agents(Humana Press Inc, 2021) Köprülü, Tuğba Kul; Ökten, Salih; Atalay, Vildan Enisoglu; Tekin, Şaban; Çakmak, OsmanThe objective of this study is to investigate the antiproliferative and cytotoxic properties and the action mechanism of substituted quinoline and tetrahydroquinolines 3, 4, 5, 7, and 8 against rat glioblastoma (C6), human cervical cancer (HeLa), human adenocarcinoma (HT29) cancer cell lines by BrdU Cell Proliferation ELISA, Lactate Dehydrogenase, DNA laddering and Topoisomerase I assays. The results of the study showed that 6,8-dibromotetrahydroquinoline 3 possess in vitro antiproliferative activity against C6, HeLa, and HT29 cell lines while morpholine/piperazine substituted quinoline 7 and 8 showed selective antiproliferative activity on C6 cell line with IC50 values 47.5 and 46.3 mu g/mL, respectively. Moreover, 6,8-dibromoTHQ 3 caused DNA fragmentation while it did not inhibit the Topoisomerase I (Topo I) enzyme. On the other hand, compound 8 did not cause DNA laddering while 8 inhibited the Topo I enzyme. According to these results, 6,8-dibromoTHQ 3 stimulates apoptosis on the C6 cell line while 6,8-dibromo-3-morhonilylquinoline (8) inhibits the Topo I enzyme to cause antiproliferative activity. Graphic abstractÖğe Arylated Quinoline and Tetrahydroquinolines: Synthesis, Characterization and Their Metabolic Enzyme Inhibitory and Antimicrobial Activities(Wiley-V C H Verlag Gmbh, 2022) Kocyigit, Ümit Muhammet; Ökten, Salih; Çakmak, Osman; Burhan, Gizem; Ataş, Mehmet; Taslimi, Parham; Gülçin, İlhamiThe aims of this study are to synthesize and characterize some new phenyl quinoline derivatives and to determine the activities of them and the recently prepared substituted phenyl quinolines against Acetylcholinesterase (AChE) and Charbonic anyhydrase (CA) enzymes and some microorganisms. The 6-phenyl- (3a) and 6,8-diphenyl-(4a) tetrahydroquinolines were prepared by treatment of 6-bromo and 6,8-dibromo-1,2,3,4-tetrahydroquinoline with phenylboronic acids in the presence of Pd catalyze in high yields with respect to our reported procedure. Then, bromination of the 6-phenyl- (3a) and 6,8-diphenyl-(4a) tetrahydroquinolines furnished novel 3-bromo phenyl substituted quinolines 14 and 11 and 8-bromo-6-pheyltetrahydroquinoline (13) in excellent yields (91, 99 and 92 %, respectively). Structures of all prepared compounds were characterized by H-1 NMR,C-13 NMR, FTIR spectroscopy and elemental analysis. Both novel prepared and recent synthesized phenyl substituted tetrahydroquinolines and quinolines were screened for human carbonic anhydrase I, II isoenzymes (hCAs I and II) and AChE inhibitory and antimicrobial activities. Results indicated that all the synthetic compounds exhibited potent inhibitory activities against all targets as compared to the standard inhibitors, revealed by IC50 values. K-i values of novel substituted (trifluoromethoxy, thiomethyl and methoxy) phenyl quinolines 3a-d, 4a-c, 8-12, and 14 for hCA I, hCA II and AChE enzymes were obtained in the ranges 0.31-12.44, 0.92-12.45, and 8.56-27.05 mu M, respectively. Moreover, phenyl quinolines 3a-b, 10, 11, 14 displayed antifungal effect against yeasts in the range of 125-15.62 mu g/mL.
