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Öğe The highly protective natural medical agents against COVID-19(Aepress Sro, 2021) Gökalp, Faik; Sayın, K.OBJECTIVE: The studies to prevent the Corona virus, which is a huge epidemic nowadays and causes the death of many people, are of great importance. Drugs to be developed to prevent the proliferation and spread of it. The active substances of the drugs have been used to prevent the attack of the COVID-19. The natural phytochemicals obtained from the traditional medicine play a big role in the inhibition of functional structures in many harmful microscopic structures. METHODS: The active role of the substances for protecting from the attack of COVID-19 have been calculated and determined by using docking. RESULTS: It has been clarified that drug active substances inhibit COVID-19. The selected active ingredients seem to have considerable inhibition effects for COVID-19. Molecular mechanical Poisson-Boltzman (MM-PSBA) calculations were used to analyse the selected molecules. CONCLUSION: This study is the first in terms of reducing the harmful effect of COVID-19 by providing effective results in a short time by guiding the experimental studies to reveal the inhibitory effect of COVID-19 Ref. Text in PDF www.elis.skÖğe The effects of perceived parental math support on middle school students' math engagement: the serial multiple mediation of math self-efficacy and math enjoyment(Springer, 2022) Sağkal, Ali Serdar; Sönmez, Melike TuralThe present study explored the direct and indirect (serial multiple mediation of math self-efficacy and math enjoyment) effects of perceived parental math support on middle school students' math engagement. A total of 374 middle school students ranging the age of 11 to 15 years completed a set of questionnaires assessing perceived parental math support, math self-efficacy, math enjoyment, and math engagement. In the analysis of structural model, a multiple-step multiple mediation analysis was employed. The findings indicated that perceived parental math support was directly and positively associated with math engagement. Additionally, math self-efficacy and math enjoyment sequentially mediated the relationship between parental math support and math engagement. The limitations and implications of the results are discussed and suggestions for future research are proposed.Öğe The effective natural compounds for inhibiting Cervical cancer(Humana Press Inc, 2021) Gökalp, FaikThe secondary compounds found in plants are of great importance in the treatment of many diseases in medicine and pharmacy. Some of these compounds have been reported to exhibit anticarcinogenic effects by inhibiting the growth and metastatic potential of cancer cells. Consumption of the required amount of vegetables and fruits appears to have a protective effect of these secondary compounds on cancer, since most of these drugs are synthesized from natural or natural origin compounds. Secondary compounds in medicinal plants have been found to have an antiproliferative effect by increasing the expression of p53 in cervical cancer cells and decreasing the expression of cyclin D1, one of the cell proliferation markers. The most important step in the fight against cancer is the development of drugs that are selectively targeted against tumor cells and targeting cancer cells to reduce damage to normal cells and prevent the growth and spread of cancer cells. Molecular insertion test is an effective tool for evaluating the bioactivity of possible molecules. In this study, the effect of natural compounds in some medicinal plants in inhibiting cervical cancer, the points where they are effective using docking has been investigated.Öğe The effect of cluster teaching with worksheets on students’ academic achievement in distance education(Anadolu Univ, 2022) Çelik, Elif; Özdemir Baki, Gülşah; Işık, AhmetThe aim of this study is to examine the effect of teaching with worksheets prepared for the 6th grade clusters in distance education on the academic achievement of students. The research was conducted with 39 students studying in a public secondary school in eastern Turkiye in the first semester of the 2020-2021 academic year. In the study, a quasi-experimental design with pretest-posttest control group was practiced to collect data. In the experimental group, the subject of cluster was taught with worksheets prepared in accordance with the constructivist teaching, and in the control group, with general teaching methods. After the practice, the Clusters Achievement Test was applied to the experimental and control group students as pre-test and post-test. The academic achievement of the experimental and control groups were compared and it was determined that there was a statistically significant difference in favor of the experimental group. Data analyzes showed that the worksheets prepared for the subject of clusters in distance education increased the academic achievement of the students. At the end of the practice carried out within the scope of the study, semi-structured interviews were conducted with 5 students in the experimental group who fully participated in the studies and activities. The findings obtained from the interviews showed that the students adopted the lessons taught with the worksheets. In addition, it was determined from the statements of the students that they were satisfied with the teaching of the lessons using worksheets in the distance education process, they participated more actively in the online lessons, and they made extra efforts in using materials and completing the activities.Öğe Teacher candidates' proficiency in utilising the REACT strategy through experimental activities(Inderscience Enterprises Ltd, 2023) Çelik, Harun; Pektaş, Hüseyin Miraç; Karaşahin, Abdulsamet; Karamustafaoğlu, OrhanIt is known that the success of a science education reform depends considerably on science teachers' knowledge, skills and activities. In accordance with this, the aim of this study is to investigate the proficiency of science teacher candidates in the use of the REACT strategy through their experimental science activities within the scope of context-based learning approach. Within this context, this study was designed in the form of a longitudinal analysis, performances were analysed periodically, and the transformation was pursued. The data obtained from documents by means of a content analysis was presented via graphical instruments through converting it into quantitative data by means of the rubric which was developed by the researchers. According to the longitudinal analysis findings, it was observed that the teacher candidates' performance in utilising the REACT strategy is parallel to the ascending number of activities.Öğe Synthesis, spectroscopic characterizations, single crystal XRD, supramolecular assembly inspection via hirshfeld surface analysis, and DFT study of a hydroxy functionalized schiff base Cu(II) complex(Elsevier, 2024) İnaç, Hasan; Ashfaq, Muhammad; Dege, Necmi; Feizi-dehnayebi, Mehran; Munawar, Khurram Shahzad; Yağ, Nermin Kahveci; Poyraz, Cinar EmineThe current work describes the synthesis, characterization, and theoretical investigation of a copper complex with a hydroxy functionalized Schiff base ligand. The complex [Cu(DHBEE)(2)] was characterized by UV-Visible, FT-IR, and mass spectrometry. The crystalline nature of [Cu(DHBEE)(2)] was examined using X-ray diffraction (XRD), revealing that the Cu2+ ion occupies a center of inversion symmetry and adopts a square planar geometry. The supramolecular assembly was stabilized by non-covalent interactions, which were further probed by Hirshfeld surface analysis along with the computation of energy of interaction between the molecular pairs and energy frameworks. Void analysis was carried out to check whether large cavities were present in the crystal or not. Density functional theory utilizing the B3LYP/LANL2DZ/6-311 G (d) level of theory indicates that the calculated bond lengths and bond angles of [Cu(DHBEE)(2)] support X-ray data. The O4 and O4(i) atoms are the sites for electrophilic attack due to the obtained results from the MEP map, Mulliken atomic charge, and Fukui function. Furthermore, HOMO-LUMO analysis verifies the enhanced chemical reactivity of the complex as compared to the ligand. The value of the energy gap for complex and ligand displays that the order of charge transfer rises as follows: [Cu(DHBEE)(2)] > (DHBEE).Öğe Synthesis and spectral properties of symmetrically arylated BODIPY dyes: Experimental and computational approach(Elsevier, 2023) Yilmaz, Rasit Fikret; Derin, Yavuz; Mısır, Büşra Albayrak; Atalay, Vildan Enisoglu; Tutar, Ömer Faruk; Ökten, Salih; Tutar, AhmetIn this study, a series of symmetrically arylated BODIPY dyes were synthesized using a pre-functionalization method, and their structures were characterized by several spectroscopic methods. The relationship between the aryl substitution pattern and the photophysical and electrochemical properties of the dyes was investigated using experimental and computational methods. It was found that electron-donating & pi;-conjugated groups at the meso position and electron-accepting & pi;-conjugated groups at the C3/C5 position led to blue-shifted spectra, while the opposite substitution pattern resulted in red-shifted spectra. Additionally, inductive electron-donating alkyl groups at the meso position produced a blue spectral shift and an alkyl group at the meso position significantly increased the fluorescence quantum yield compared to the arylated counterparts. Computational investigations revealed that a thioanisyl group at the C3/C5 position resulted in a significantly narrow band gap. These results provide valuable insights into the design and development of new BODIPY dyes with tailored properties for various applications.Öğe Production and characterization of fruit jam with activated pectin using wild hawthorn puree (Crataegus monogyna Jacq.)(Taylor & Francis Ltd, 2023) Farzaliev, Elsevar Babaoglu; Ökten, SalihIn this study, we developed a technology for the production of jelly confiture based on natural hawthorn puree. The use of activated low-esterified hawthorn pectin in the recipe was shown to increase the complexing ability of the product in relation to zinc and lead ions, making it suitable for functional preventive nutrition. The final product was characterised by a bright orange-yellow colour, a distinct hawthorn taste and odour, and a gelatinous consistency. Evaluation of the product based on organoleptic, physicochemical, and microbiological indicators showed that it had high nutritional and physiological value due to its retention of native micronutrients, high content of potassium, magnesium, and calcium, and antioxidant activity. The use of this product in a daily diet can satisfy the daily need for physiologically active substances and food ingredients. Overall, the use of natural puree from wild hawthorn fruit in the technology of jelly confiture allows for the expansion of raw material sources in the production of confectionery products with high nutritional and physiological value. [GRAPHICS]Öğe Problem Posing Via Scriptwriting: What Instructional Flows Do Mathematics Teachers Use in Implementing the Problem-Posing Task?(Springer, 2024) Kar, Tuğrul; Öztürk, Ferhat; Öcal, Mehmet Fatih; Özkaya, MerveThe present study aimed to describe teachers' instructional flows when implementing a mathematical problem-posing task using scriptwriting technique. With matchsticks, a growing pattern that increases by a constant unit was created and presented to the teachers as a problem-posing situation. We analyzed the instructional flows in 50 scripts, taking into account situations recognized in the problem-posing field as critical for integrating problem posing into mathematics classrooms. We determined three instructional flows in the scripts: pose and solve cycle-based, observation-based, and problem-solving based, the first being the most common. We presented a new problem-posing instructional model and discussed its potential benefits for student learning.Öğe Pre-service elementary teachers' noticing expertise of students' mathematical thinking: the case of fractions(Taylor & Francis Ltd, 2023) Coşkun, Sümeyra Doğan; Sitrava, Reyhan Tekin; Bostan, Mine IsiksalThe purpose of the study is to investigate pre-service elementary teachers' noticing expertise of students' mathematical thinking within the context of fractions. For this purpose, 32 pre-service elementary teachers were asked to examine students' answers and ways of thinking given in written excerpts related to fractions. The data was mainly analysed using the constant comparative method to identify similarities and differences in pre-service elementary teachers' answers based on the existing Professional Noticing of Children's Mathematical Thinking framework developed by Jacobs, Lamb, and Philipp ([2010]. Professional noticing of children's mathematical thinking. Journal for Research in Mathematics Education, 41(2), 169-202.). The findings indicated that the vast majority of the pre-service elementary teachers showed at least a limited level in all professional noticing skills: attending, interpreting, and deciding how to respond. The findings serve to inform teacher educators to include written excerpts in their mathematics teaching courses and, thus result in improvement in pre-service teachers' noticing skills.Öğe Biological activity and molecular docking studies of some new quinolines as potent anticancer agents(Humana Press Inc, 2021) Köprülü, Tuğba Kul; Ökten, Salih; Atalay, Vildan Enisoglu; Tekin, Şaban; Çakmak, OsmanThe objective of this study is to investigate the antiproliferative and cytotoxic properties and the action mechanism of substituted quinoline and tetrahydroquinolines 3, 4, 5, 7, and 8 against rat glioblastoma (C6), human cervical cancer (HeLa), human adenocarcinoma (HT29) cancer cell lines by BrdU Cell Proliferation ELISA, Lactate Dehydrogenase, DNA laddering and Topoisomerase I assays. The results of the study showed that 6,8-dibromotetrahydroquinoline 3 possess in vitro antiproliferative activity against C6, HeLa, and HT29 cell lines while morpholine/piperazine substituted quinoline 7 and 8 showed selective antiproliferative activity on C6 cell line with IC50 values 47.5 and 46.3 mu g/mL, respectively. Moreover, 6,8-dibromoTHQ 3 caused DNA fragmentation while it did not inhibit the Topoisomerase I (Topo I) enzyme. On the other hand, compound 8 did not cause DNA laddering while 8 inhibited the Topo I enzyme. According to these results, 6,8-dibromoTHQ 3 stimulates apoptosis on the C6 cell line while 6,8-dibromo-3-morhonilylquinoline (8) inhibits the Topo I enzyme to cause antiproliferative activity. Graphic abstractÖğe Arylated Quinoline and Tetrahydroquinolines: Synthesis, Characterization and Their Metabolic Enzyme Inhibitory and Antimicrobial Activities(Wiley-V C H Verlag Gmbh, 2022) Kocyigit, Ümit Muhammet; Ökten, Salih; Çakmak, Osman; Burhan, Gizem; Ataş, Mehmet; Taslimi, Parham; Gülçin, İlhamiThe aims of this study are to synthesize and characterize some new phenyl quinoline derivatives and to determine the activities of them and the recently prepared substituted phenyl quinolines against Acetylcholinesterase (AChE) and Charbonic anyhydrase (CA) enzymes and some microorganisms. The 6-phenyl- (3a) and 6,8-diphenyl-(4a) tetrahydroquinolines were prepared by treatment of 6-bromo and 6,8-dibromo-1,2,3,4-tetrahydroquinoline with phenylboronic acids in the presence of Pd catalyze in high yields with respect to our reported procedure. Then, bromination of the 6-phenyl- (3a) and 6,8-diphenyl-(4a) tetrahydroquinolines furnished novel 3-bromo phenyl substituted quinolines 14 and 11 and 8-bromo-6-pheyltetrahydroquinoline (13) in excellent yields (91, 99 and 92 %, respectively). Structures of all prepared compounds were characterized by H-1 NMR,C-13 NMR, FTIR spectroscopy and elemental analysis. Both novel prepared and recent synthesized phenyl substituted tetrahydroquinolines and quinolines were screened for human carbonic anhydrase I, II isoenzymes (hCAs I and II) and AChE inhibitory and antimicrobial activities. Results indicated that all the synthetic compounds exhibited potent inhibitory activities against all targets as compared to the standard inhibitors, revealed by IC50 values. K-i values of novel substituted (trifluoromethoxy, thiomethyl and methoxy) phenyl quinolines 3a-d, 4a-c, 8-12, and 14 for hCA I, hCA II and AChE enzymes were obtained in the ranges 0.31-12.44, 0.92-12.45, and 8.56-27.05 mu M, respectively. Moreover, phenyl quinolines 3a-b, 10, 11, 14 displayed antifungal effect against yeasts in the range of 125-15.62 mu g/mL.Öğe Artificial intelligence applications in education: Natural language processing in detecting misconceptions(Springer, 2024) Kökver, Yunus; Pektaş, Hüseyin Miraç; Çelik, HarunThis study aims to determine the misconceptions of teacher candidates about the greenhouse effect concept by using Artificial Intelligence (AI) algorithm instead of human experts. The Knowledge Discovery from Data (KDD) process model was preferred in the study where the Analyse, Design, Develop, Implement, Evaluate (ADDIE) instructional design cycle was used. The dataset obtained from 402 teacher candidates was analysed by Natural Language Processing (NLP) methods. Data was classified using Machine Learning (ML), one of the AI tools, and supervised learning algorithms. It was concluded that 175 teacher candidates did not have sufficient knowledge about the concept of greenhouse effect. It was found that the AI algorithm with the highest accuracy rate and used to predict teacher candidates' misconceptions was Multilayer Perceptron (MLP). Furthermore, through the Enhanced Ensemble Model Architecture developed by researchers, the combination of ML algorithms has achieved the highest accuracy rate. The kappa (kappa) value was examined in determining the significant difference between the AI algorithm and the human expert evaluation, and it was found that there was a significant difference, and the strength of agreement was significant according to the research findings. The findings of the current study represent a significant alternative to the prevailing pedagogical approach, which has increasingly come to rely on information technologies in the process of improving conceptual understanding through the detection of conceptual misconceptions. In addition, recommendations were made for future studies.Öğe An investigation into the usage of black cumin derivatives against cancer and COVID-19 as the nature medicine(Taylor & Francis Inc, 2024) Gökalp, FaikBlack cumin has been used as a spice and food preservative for years. Thymol, thymoquinone, thymohydroquinone and dihydrothymoquinone are the most important natural agents in black cumin. In order to determine the most active compound in black cumin the theoretical calculations have been carried out in different phases by using the density functional theory (DFT). The inhibition effect of black cumin derivatives on Histone deacetylase 2 (HDAC2) has been determined and supported the experimental studies without losing time and matter. The chemical activity, stability and solubility of the active substances in black cumin have been theoretically calculated. The chemical active compounds had been investigated in the black seeds when extracted with water. Their stability and polarity in blood and water are important parameters. HDAC2- dihydrothymoquinone interaction has been investigated. It has been determined that the active substances found in black cumin are very effective in protecting ACE2 against COVID-19 and by comparing the docking results of important receptors and selected ligands on COVID-19.Öğe An Investigation into the Usage of Monosaccharides with GLUT1 and GLUT3 as Prognostic Indicators for Cancer(Routledge Journals, Taylor & Francis Ltd, 2022) Gökalp, FaikThe monosaccharides, glucose, fructose and galactose, are the most common and simplest forms of carbohydrates. The aim of this study was to determine the uptake of glucose as a potential therapeutic target agent for cancer treatment. The stability and transportation calculations of the monosaccharides were carried out in the blood phase by using the density functional theory and docking. The reactivity of monosaccharides, disaccharides and their transportation with GLUT1 and GLUT3 as prognostic indicators for cancer were investigated. The theoretical results of this study were supported by those reported in the literature and used in the prediction of the mechanisms of monosaccharides and the interpretation of their reactivities.Öğe Algorithmic thinking development through physical computing activities with Arduino in STEM education(Springer, 2022) Sarı, Uğur; Pektaş, Hüseyin Miraç; Şen, Ömer Faruk; Çelik, HarunThe need to benefit from information technologies in the twenty-first century digital age is increasing in all economies to overcome problems and difficulties and to have desired solutions. So, developing algorithmic thinking has been important as a skill that requires the application of knowledge from different disciplines, especially science, technology, engineering and mathematics, and improves solving real life problems. Therefore, there is a need for practical studies on how to develop algorithmic thinking and what kind of activities and learning content can be used in classrooms. The effect of STEM-focused physical computing activities with Arduino on algorithmic thinking skills and STEM awareness of teacher candidates was investigated by mixed-method research. In addition, student-teacher roles in the activities and the advantages-disadvantages of the activities were discussed by considering the views of the teacher candidates. The study group of the research consists of twenty-four volunteer students. They were selected by purposive sampling method, and they are studying in the last year of science teaching undergraduate program at twelve different universities in Turkey. The findings showed that STEM-focused physical computing activities developed teacher candidates' algorithmic thinking skills. Therefore, it can be said that the activities increased the awareness of teacher candidates about STEM. The effect size (Cohen d) of the STEM awareness scale was calculated as 0.98 according to the pre-test and post-test averages.Öğe A Study on Natural Control against Nematodes and Whiteflies with Marigold, Known as an Antagonist Plant(Springer, 2023) Gökalp, FaikThe importance of finding natural solutions for the protection of our health in the fight against pests in agriculture is increasing day by day. In this study, the interaction of the active ingredients in marigolds as the great importance as a garden flower, with nematode and whitefly receptors as ligands in the fight against them, have been investigated by chemical calculation method. The inhibition effect of ligands (alpha-Terthienyl, Quercetagetin in marigold) on nematode and whitefly receptors in this plant was determined by comparing the binding energy values with reference drug active ingredients (imidacloprid, Perhexiline).This calculation method, the accuracy determined by different studies, is very important in terms of determining the most active substance in a short time, preventing time and substance loss, and will guide the experimental studies and applications to be made in this field.Öğe Bromination and conversion of tetrahydro-1H-indene to bisoxirane with a new approach: synthesis, structural characterization by spectroscopic and theoretical methods, and biological analysis supported by DFT and docking(Tubitak Scientific & Technological Research Council Turkey, 2023) Yılmaz, Raşit Fikret; Erkan, Sultan; Ökten, Salih; Tutar, Ahmet; Şahin, ErtanIn this study, a new method for synthesizing diepoxides is proposed. Tetrahydroindene 1 was brominated with NBS in the presence of LiClO4 and acetic acid, resulting in the formation of dibromodiacetate derivatives 2 and 3. Treatment of compounds 2 and 3 with NaOH in methanol produced a mixture of diepoxides 4 and 5. Additionally, direct bromination of tetrahydro-1H-indene yielded tetrabromo octahydroindene isomers 6 and 7. The structures of the compounds were characterized using spectroscopic techniques such as H-1 NMR, C-13 NMR, APT, COSY, and XRD. The new method provides an easy and selective route to access epoxides for the synthesis of various chemicals. This study also highlights the selective formation of endo-exo and exo-exo orientations of the obtained diepoxides, distinguishing it from previous studies. The stability and properties of the stereoisomers were investigated using computational methods, revealing the most stable configurations. Reactive sites in the molecules were identified using contour diagrams and molecular electrostatic potential maps. The anticancer properties of the compounds were evaluated in silico, comparing them to 5-fluorouracil (5-FU) against several cancer cell lines. The compounds exhibited the most effective anticancer activity against MCF-7 cells, with the order of anticancer activities generally determined as 2 > 7 > 3 > 6 > 5 > 4 > 5-FU.Öğe Zeytin Etken Maddesi Olan Oleuropein’in Kimyasal Aktivitesinin Teorik Olarak Araştırılması(2017) Gökalp, FaikBu çalışmanın amacı: zeytinin yapraklarında, olgunlaşmamış meyvelerinde bulunan ona acı tadı veren oleuropein ile önemli bir etken madde olan timolün termodinamiksel özellikleri, kimyasal aktiflik parametrelerinin (?G, HOMO, LUMO, ?(HOMO-LUMO), dipol moment) hesaplanmasıdır. Ayrıca bu değerlerin karşılaştırmasıyla birlikte radikalik yapılara karşı reaktif olup olmadıklarının tespit edilerek bununla ilgili yapılacak deneysel çalışmalara yön verilmesidir. Hesaplama yöntemi olarak RHF yöntemi kullanılmıştır. Bu yöntemler ve temel küme kullanılarak bileşiklerin tam optimize geometrik yapıları belirlenerek kimyasal aktivitesi değerlendirilmiştir. Hesaplamalarda Gaussian09W paket programından yararlanılmıştır. Bu yöntemi seçmemizin nedeni; molekülümüzün özelliklerini kısa sürede teorik olarak görmek, diğer yandan madde ve zaman kaybını önlemesi açısından oldukça önemli ve tercih edilebilir bir yöntem olmasıdır. Diğer önemli bir etken antioksidan madde olan timol ile karşılaştırıldığında; Oleuropeinde ki fenolik yapılardan dolayı kararsız özellikle radikalik yapılara karşı reaksiyon vermeye yatkın olduğu görülmektedir. Sonuç olarak; Oleuropein'in RHF ile yapılan hesaplamalarından elde edilen veriler ışığında; fenolik yapılardan dolayı kararsız, reaksiyon vermeye yatkın olduğunu ve metabolizmada zararlı mikroorganizmaların hücre yapısını bozarak antimikrobiyal etkili olacağı söylenebilirÖğe Proje tabanlı öğrenme yaklaşımı üzerine uygulama güçlük ölçeğinin geliştirilmesi(2009) Pektaş, M.Hüseyin; Çelik, Harun; Köse, SacitBu çalışmanın amacı, fen ve teknoloji öğretmenlerinin proje tabanlı öğrenme uygulamalarında karşılaştıkları sorunlara katılma düzeylerini ölçen, geçerli ve güvenilir bir ölçme aracı geliştirmektir. Geliştirilen ölçek, Kırıkkale merkeze bağlı ilköğretim okullarında görev yapan fen ve teknoloji öğretmenleri arasından rasgele örnekleme yöntemiyle seçilen 82 öğretmene uygulanmıştır. 5’li likert tipindeki ölçek, 30 maddeden oluşmaktadır. Ölçeğin yapı geçerliğini belirlemek amacıyla yapılan faktör analizi sonucunda ölçeğin, faktör yüklerinin 0.93- 0.62 arasında değişen dört faktörden oluştuğu ve Kaiser-Meyer Olkin (KMO) değerinin 0.81, güvenirlik çalışması için hesaplanan iç tutarlık katsayısı (Cronbach Alpha) değerinin ? =0.92 olduğu belirlenmiştir. Geçerlik ve güvenirlik çalışmalarına ilişkin elde edilen bulgular ölçeğin geçerli ve güvenilir bir yapıya sahip olduğunu göstermektedir.
