Synthesis and Characterization of Chitosan/Sericin Composite Blend Membranes Containing Silver Nanoparticles for Effective Antibacterial Applications

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dc.contributor.authorNiyaz, Zeynep
dc.contributor.authorGök, Zehra Gün
dc.date.accessioned2025-01-21T16:28:33Z
dc.date.available2025-01-21T16:28:33Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractDue to drug-resistant bacteria, antimicrobial composite materials that will replace antibiotics are among the current research topics. In this study, environmentally-friendly, low-cost, easy-to-synthesize chitosan/silk sericin/silver nanoparticles (Cht/SS/AgNPs) membranes were obtained for use in antibacterial applications. For material synthesis, firstly, AgNPs were obtained by mixing solution of 2 % sericin (at pH 11)-10 mM AgNO3 at 100 °C with hydrothermal method and AgNPs formation was confirmed by UV-Vis measurements. Then, sericin/AgNPs solution was added to chitosan solutions at different ratios and Cht/SS/AgNPs composites were obtained by solvent casting method. The final forms of the membranes were characterized by fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM)-energy dispersive X-ray spectroscopy (EDS), and thermogravimetric analysis (TGA). Water retention capacities and mechanical properties of the membranes were also determined. Finally, antibacterial and biocompatibility properties were evaluated by disc diffusion test method on Escherichia coli and Staphylococcus aureus and MTT on L929 fibroblast cell line, respectively. The obtained membranes had homogeneous appearance, high swelling ratios, good mechanical properties. The composites also showed excellent antibacterial activity, especially on S. aureus and good biocompatibility. In summary, Cht/SS/AgNPs composites can be used as an alternative polymeric antibacterial materials especially as the wound-dressing materials or functional packaging materials. © 2024 Wiley-VCH GmbH.
dc.description.sponsorshipKırıkkale Üniversitesi, KU; Institute of Science; Kırıkkale University Scientific Research Unit, (2023/124)
dc.identifier.doi10.1002/slct.202403514
dc.identifier.issn2365-6549
dc.identifier.issue40
dc.identifier.scopus2-s2.0-85207685678
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/slct.202403514
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23578
dc.identifier.volume9
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofChemistrySelect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectBlend membrane; Chitosan; Functional materials; Silk sericin; Silver nanoparticles
dc.titleSynthesis and Characterization of Chitosan/Sericin Composite Blend Membranes Containing Silver Nanoparticles for Effective Antibacterial Applications
dc.typeArticle

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