#YOK
[ X ]
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Kırklareli Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu yüksek lisans tez çalışmasında; periferal olarak karboksilik asit grupları ile sübstitüe çinko metalli ftalosiyanin sentezlenmiş ve polivinil alkol/kitosan (PVA/CS) membranları kullanılarak transdermal salım için deneysel çalışmalar yapılmıştır. Optimum transdermal salım profiline PVA/CS, membran kalınlığı, pH, sıcaklık, Triton X-100 ve ilaç derişimi parametrelerinin etkileri değerlendirilmiştir. Deneysel incelemelerin sonucunda PVA/CS 7/5, membran kalınlığı 26,5 ?m, pH 5,5, sıcaklık 37 °C, Triton X-100 0,2 mL, derişim basamağında ilaç miktarı 3 mg olan şartlarda transdermal ilaç salım verimi %92,7 olarak elde edilmiştir. Anahtar Kelimeler: Metalli ftalosiyanin, Polivinil alkol, Kitosan, Transdermal ilaç salımı
In this master's thesis; peripherally substituted zinc metallo phthalocyanine with substituted carboxylic acid groups was synthesized and experimental studies were carried out for transdermal release using polyvinyl alcohol/chitosan (PVA/CS) membranes. The effects of PVA/CS, membrane thickness, pH, temperature, Triton X-100 and drug concentration parameters on the optimum transdermal release profile were evaluated. As a result of the experimental investigations, when PVA/CS 7/5, membrane thickness 26,5 ?m, pH 5,5, temperature 37 °C, Triton X-100 0,2 mL, the amount of drug in the concentration step is 3 mg, the transdermal drug release efficiency is 92.7% was obtained. Keywords: Metallo phthalocyanine, Polyvinyl alcohol, Chitosan, Transdermal drug release
In this master's thesis; peripherally substituted zinc metallo phthalocyanine with substituted carboxylic acid groups was synthesized and experimental studies were carried out for transdermal release using polyvinyl alcohol/chitosan (PVA/CS) membranes. The effects of PVA/CS, membrane thickness, pH, temperature, Triton X-100 and drug concentration parameters on the optimum transdermal release profile were evaluated. As a result of the experimental investigations, when PVA/CS 7/5, membrane thickness 26,5 ?m, pH 5,5, temperature 37 °C, Triton X-100 0,2 mL, the amount of drug in the concentration step is 3 mg, the transdermal drug release efficiency is 92.7% was obtained. Keywords: Metallo phthalocyanine, Polyvinyl alcohol, Chitosan, Transdermal drug release
Açıklama
Fen Bilimleri Enstitüsü, Kimya Ana Bilim Dalı
Anahtar Kelimeler
Kimya, Chemistry
