Autologous serum effect on corneal endothelial damage in the phacoemulsification rabbit model

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dc.contributor.authorUsta, Gülşah
dc.contributor.authorOğurel, Reyhan
dc.contributor.authorOnaran, Zafer
dc.contributor.authorPekcan, Zeynep
dc.contributor.authorOğurel, Tevfik
dc.contributor.authorKarsli, Birkan
dc.contributor.authorGökçinar, Nesrin Büyüktortop
dc.date.accessioned2020-06-25T18:22:48Z
dc.date.available2020-06-25T18:22:48Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.descriptionusta, gulsah/0000-0002-0065-4384
dc.description.abstractAim: This study used specular microscopy to evaluate the possible effects of applying autologous serum to the anterior chamber on the corneal endothelial damage created by the ultrasonic vibrations of phacoemulsification (PHACO) in rabbits. Material and Method: The study, which was approved by the Ethics Committee, involved both eyes of nine 5 month-old (about 3 kg) New Zealand genus albino male rabbits. Group 1(6 eyes) received only an application of 0.2 ml autologous serum; Group 2 (6 eyes) received only the ultrasonic vibrations for 20 seconds: and Group 3 (6 eyes) received 0.2 ml autologous serum followed by ultrasonic vibrations for 20 seconds. Measurements were made before the intervention and at the 1st and 7th days postoperatively using specular microscopy, intraocular pressure, and pachymetry metrics, and the data were compared statistically. Results: Postoperative 1st week, the cornea thickness increased from 385 mu to 445 mu in Group 2 (PHACO only) and from 398 mu to 402 mu in Group 2 (PHACO plus autologous serum). However, this difference was not statistically significant. Postoperative 1st day standard deviation (p < 0.05) and variation coefficient (p < 0.05) values of the specular microscopy parameters for Groups 2 and 3 were higher than for Group 1. Postoperative 1st week it was observed that the parameters of the three groups were similar and had returned to the preoperational values. Between the endothelial cell numbers, the cell density, the cell space average, the largest and the smallest percentage of the cell and the hexagonal cell area values, there were no statistically significant differences at the three measurement time points. Discussion: This study showed that, after the phacoemulsification process, autologous serum applied to the anterior chamber can, by positive possible effects on endothelial pump functions, reduce corneal edema without morphological changes, which can be confirmed with specular microscopyen_US
dc.identifier.doi10.4328/JCAM.5041
dc.identifier.endpage335en_US
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.startpage330en_US
dc.identifier.urihttps://doi.org/10.4328/JCAM.5041
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6909
dc.identifier.volume8en_US
dc.identifier.wosWOS:000435647500019
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherDerman Medical Publen_US
dc.relation.ispartofJournal Of Clinical And Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPhacoemulsificationen_US
dc.subjectCorneal Endotheliumen_US
dc.subjectAutologous Serumen_US
dc.subjectSpecular Microscopyen_US
dc.titleAutologous serum effect on corneal endothelial damage in the phacoemulsification rabbit modelen_US
dc.typeArticle

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