Are antifungals effective in rhinosinusitis?
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Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer International Publishing
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
It is now more popular to refer to rhinosinusitis rather than sinusitis, since inflammation virtually never occurs in the sinuses alone, without a nasal component. It is probable that expert disagreement on how to define CRS stems from the multifaceted nature of the disorder and from our imperfect knowledge about the underlying pathogenesis of sinus mucosal inflammation. It has been hypothesised that a number of different processes may drive inflammation: infection by bacteria (which may then produce a biofilm and secrete supertoxins), infection by viruses, allergic responses to fungal organisms (allergic fungal sinusitis), infection by fungi (invasive), immune malfunction targeting non-pathogenic fungal organisms found throughout the environment, humoral immunodeficiency and rhinitis of allergic and nonallergic type. This lack of clear diagnostic criteria to permit recruitment into trials, due to the disparate nature of CRS, coupled with, at best, a partial knowledge of the disorder's pathogenetic basis, results in a situation where clinicians need to rely on a slender evidence base when deciding what therapy to offer patients. In this chapter, antifungal treatment in rhinosinusitis is reviewed. © Springer Nature Switzerland AG 2021.
Açıklama
Anahtar Kelimeler
Antifungal; Rhinosinusitis; Treatment
Kaynak
Challenges in Rhinology
WoS Q Değeri
Scopus Q Değeri
N/A
