Investigation of the neutrophil/lymphocyte and monocyte to high-density lipoprotein cholesterol ratios in differentiated thyroid cancers

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dc.contributor.authorDal, Derya
dc.contributor.authorYıldız, Faruk
dc.contributor.authorKeskin, Havva
dc.contributor.authorBayrak, Muharrem
dc.contributor.authorÖzmen, Hilal Kızıltunç
dc.contributor.authorDurmaz, Şenay
dc.contributor.authorÇarlıoğlu, Ayşe
dc.date.accessioned2025-01-21T16:17:12Z
dc.date.available2025-01-21T16:17:12Z
dc.date.issued2020
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIntroduction: Thyroid cancers are the most common malignant tumors of endocrine origin. They are classified depending on their histopathological and clinical behaviors. Papillary and follicular cancers are classified as differentiated thyroid carcinomas (DTCs). The neutrophil/lymphocyte ratio (NLR) and the monocyte to highdensity lipoprotein cholesterol ratio (MHR) have recently been shown to be powerful markers of oxidative stress and systemic inflammation, and the MHR has been revealed as a potent marker of mortality in coronary heart disease associated with coronary atherosclerosis. The aim of this study was to evaluate these markers in patients diagnosed with DTC. Material and Method: One hundred twenty-five patients newly diagnosed with DTC and a 75-member control group consisting of entirely healthy individuals were included in the study. The patient and control groups were evaluated by investigation of cholesterol and hematological parameters following 12-h fasting. Results: Significant differences were determined between the patient and control groups in terms of mean NLR (3.2±2.8 vs 2.4±1.3, respectively, p=0.013) and MHR (0.102±0.079 vs, 0.038±0.052 respectively, p<0.001) values. In the correlation analysis, positive correlation was determined between the NLR and white cell count (r=0.530, p<0.001), neutrophil count (r=0.293, p<0.001) and C reactive protein (CRP) (r=0.371, p=0.005), while negative correlation was determined between the NLR and lymphocyte count (r=-0.271, p=0.001). Conclusion: The study data show that DTCs increase systemic inflammation.
dc.identifier.doi10.32322/jhsm.689142
dc.identifier.endpage175
dc.identifier.issn2636-8579
dc.identifier.issue2
dc.identifier.startpage172
dc.identifier.trdizinid485859
dc.identifier.urihttps://doi.org/10.32322/jhsm.689142
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/485859
dc.identifier.urihttps://hdl.handle.net/20.500.12587/22587
dc.identifier.volume3
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJournal of health sciences and medicine (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectGenel ve Dahili Tıp
dc.subjectOnkoloji
dc.titleInvestigation of the neutrophil/lymphocyte and monocyte to high-density lipoprotein cholesterol ratios in differentiated thyroid cancers
dc.typeArticle

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