Cellular interactions and design principles of glyco-gold nanoparticles for drug delivery applications
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Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
An escalating tendency prevails to manipulate gold-based nanoparticles decorated on their surfaces with different types of carbohydrates or glycopolymers for the development of versatile nanoplatforms—the so-called glyco-gold nanoparticles (GAuNPs) here—for drug delivery applications. Due to the ease of their surface modification, inherent inertness, and biocompatible nature, gold nanoparticles (AuNPs) are one of those first preferred candidates in this field. Coating of AuNPs with saccharide moieties also makes them gain unique properties such as multivalent binding abilities, active targeting, receptor-mediated internalization of drugs, enhanced biocompatibility, colloidal stability, stealth ability, and so on. This chapter deals with the synthesis methods and design parameters of GAuNPs followed by very detailed drug delivery applications, mainly focusing on the cellular interactions and design parameters in state-of-the-art research. The chapter ends with a concluding remark emphasizing the hurdles encountered in synthesis methodologies and the translation of the bench-top characterization results to different biomedical applications. © 2024 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
antibacterial, vaccine; anticancer; carbohydrates; drug delivery; glycoconjugate; Gold nanoparticles
Kaynak
Gold Nanoparticles for Drug Delivery
WoS Q Değeri
Scopus Q Değeri
N/A
