Prognostic significance of caspase- 3, Bcl-2, P53 and GSTPI expressions in lung adenocarcinoma

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dc.contributor.authorOguztuzun S.
dc.contributor.authorOguz Ada A.
dc.contributor.authorKilic M.
dc.contributor.authorCakir E.
dc.contributor.authorYilmaz A.
dc.date.accessioned2020-06-25T15:17:21Z
dc.date.available2020-06-25T15:17:21Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractLung adenocarcinoma is one of the most fatal cancers in humans, and many factors are known to contribute to its poor prognosis. The aim of this work is to investigate the prognostic value of the apoptosis-regulating markers (caspase-3, bcl-2, p53) and the important detoxification enzyme (GST pi), and analyze the relationships among these immunohistochemical (IHC) results, patients' clinical characteristics, and survival. IHC stainings were performed on 89 lung adenocarcinoma specimens obtained from 89 patients from the Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey. The medical records of the patients were reviewed retrospectively. The correlation between the presence of protein expression and clinicopathological parameters (gender, age, tumor stage and histology) was examined by using the Pearson correlation test. Survival analysis was carried out by the Kaplan-Meier method. The prevalence of caspase 3, bcl-2, p53, and GST pi expression was 48%, 57%, 95% and 52%, respectively. The expression rate of p53 was relatively high in smokers than that in non-smokers. There were no correlations among the immunoreactivities of bcl- 2 and GST pi in clinical stage, and overall survival. However, there was a significant relationship between caspase-3 and p53 expressions and overall survival. Caspase-3 expression was correlated with good prognosis, and p53 expression was correlated with poor prognosis.en_US
dc.identifier.endpage89en_US
dc.identifier.issn13004182
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85008502607
dc.identifier.scopusqualityQ4
dc.identifier.startpage83en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2323
dc.identifier.volume38en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSociety of Pharmaceutical Sciences of Ankara (FABAD)en_US
dc.relation.ispartofFabad Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBcl-2en_US
dc.subjectCaspase-3en_US
dc.subjectGlutathione-S-transferase pien_US
dc.subjectLung adenocarcinomaen_US
dc.subjectP53en_US
dc.titlePrognostic significance of caspase- 3, Bcl-2, P53 and GSTPI expressions in lung adenocarcinomaen_US
dc.typeArticle

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