The effects of repeated sevoflurane anesthesia on renal tubular enzymes in rabbits

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dc.contributor.authorBaşar, Hülya
dc.contributor.authorBüyükkoçak, Ünase
dc.contributor.authorKaymak, Çetin
dc.contributor.authorÖzcan, Şaziye
dc.contributor.authorTüzüner, Filiz
dc.date.accessioned2025-01-21T16:28:45Z
dc.date.available2025-01-21T16:28:45Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.description.abstractSevoflurane, one of new inhalation agents, is metabolized to organic and inorganic fluoride metabolites. Nephrotoxicity is due to free fluoride. In this study; we investigated the renal effects of repeated and different concentrations of sevoflurane anesthesia, experimentally. Sensitive urinary indicators n-asetil-d- glukozaminidaz (NAG), alkalen phosfatase (ALP), and gamma glutamil transferase (GGT) were assessed. This study was performed in 14, male New Zelland rabbits. Rabbits were divided into two groups (n=7). Group I (n=7) received sevoflurane 1% and Group II (n=7) 3% sevoflurane with O2+N2O (4 Lmin-1) 3 hours a dayfor 3 days Urine samples were collected via a special apparatus for 24 hours preoperative and after anesthesia. Urine samples were taken five days after the last administration of anesthesia and NAG, ALP and GGT levels in urine were determined. Blood samples taken from ear veins were obtained to determine BUN and Creatine. In Group II, urinary NAG levels increased significantly on the third day and a significant increase in GGT was observed on second and third days. There was no significant change in BUN, Cre and urinary ALP. NAG and GGT levels returned to normal on the 9th day. We concluded that, the effects of repeated sevoflurane administration on renal system are temporary.
dc.identifier.endpage293
dc.identifier.issn1300-0578
dc.identifier.issue4
dc.identifier.scopus2-s2.0-0346783334
dc.identifier.scopusqualityQ4
dc.identifier.startpage290
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23629
dc.identifier.volume11
dc.indekslendigikaynakScopus
dc.language.isotr
dc.relation.ispartofAnestezi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectNAGA; Renal toxicity; Sevoflurane
dc.titleThe effects of repeated sevoflurane anesthesia on renal tubular enzymes in rabbits
dc.title.alternativeTavşanlarda tekrarlanan sevofluran uygulamalarinin renal tübüler enzimler üzerine etkile?i
dc.typeArticle

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