Assessment of PTCH1a promoter methylation in BCC carcinogenesis

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dc.contributor.authorSayın Kocakap D.B.
dc.date.accessioned2020-06-25T15:17:26Z
dc.date.available2020-06-25T15:17:26Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBasal Cell Carcinoma (BCC) is the most common cancer in humans. It is known that PTCH1 mutations in Sonic Hedgehog pathway play significant role in BCC pathogenesis. However PTCH1 (Patched) inactivation through promoter methylation is still under investigation. In this study, promoter methylation of the PTCH1 gene was analysed by Combined Bisulphite Restriction Analysis in 10 formalin-fixed paraffin-embedded (FFPE) BCC tissues. There was no methylation in any of the samples. Results suggest that PTCH1 promoter methylation is not effective in BCC carcinogenesis and FFPE tissues are not suitable for methylation analysis since 44 specimens were included in the study and only 10 of them gave result. © 2014, Yuzuncu Yil Universitesi Tip Fakultesi, Universitas Indonesia. All rights reserved.en_US
dc.identifier.endpage106en_US
dc.identifier.issn13010883
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85013025277
dc.identifier.scopusqualityQ4
dc.identifier.startpage105en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2363
dc.identifier.volume19en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherYuzuncu Yil Universitesi Tip Fakultesien_US
dc.relation.ispartofEastern Journal of Medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBasal cell carcinomaen_US
dc.subjectCOBRAen_US
dc.subjectMethylationen_US
dc.subjectPTCH1en_US
dc.titleAssessment of PTCH1a promoter methylation in BCC carcinogenesisen_US
dc.typeArticle

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