Phosphorus-nitrogen compounds Part 32. Structural and thermal characterizations, antimicrobial and cytotoxic activities, and in vitro DNA binding of the phosphazenium salts

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dc.contributor.authorAkbas, Huseyin
dc.contributor.authorOkumus, Aytug
dc.contributor.authorKaradag, Ahmet
dc.contributor.authorKilic, Zeynel
dc.contributor.authorHokelek, Tuncer
dc.contributor.authorKoc, L. Yasemin
dc.contributor.authorTurk, Mustafa
dc.date.accessioned2020-06-25T18:16:53Z
dc.date.available2020-06-25T18:16:53Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionHokelek, Tuncer/0000-0002-8602-4382; Aydin, Betul/0000-0002-9092-1350; Akbas, Huseyin/0000-0002-3013-9033; okumus, aytug/0000-0002-2169-5695
dc.description.abstractThe salicylic acid salts of fully substituted mono(4-fluorobenzyl)spirocyclotriphosphazenes (10-15) were prepared. The structures of these phosphazenium salts (10a-15a) were determined by elemental analyses, FTIR and H-1, C-13{H-1}, P-31{H-1} NMR techniques. The crystal structure of 14a was verified by X-ray diffraction analysis. The thermal properties of the salts were investigated using TG/DTA and DSC instruments. The results obtained from DSC indicated that the melting temperatures and latent heats of the compounds were in the ranges of 107.76-143.04 A degrees C and 41.64-69.73 J g(-1), respectively. The thermal stabilities of the phosphazenium salts (10a-15a) are found to be different, but they have a similar decomposition mechanism. The compounds 14a and 15a exhibit noticeable cytotoxic activity against DLD-1 cancer cells, and they seem to be good candidates for being anticancer agents. All of the compounds have an antimicrobial effect on bacterial and yeast strains within the ranges of 312-625 A mu M (bacterial strains) and 19.5-312 A mu M (yeast strains). It is found that compounds 13a-15a were most effective against yeast strains. Moreover, interactions between the salts and pBR322 plasmid DNA show that 14a and 15a cleave the DNA and decrease the intensity of form I. BamHI and HindIII digestion results demonstrate that the compounds are not bound with G/G and A/A nucleotides, respectively.en_US
dc.description.sponsorshipAnkara University, Scientific Research UnitAnkara University [09B4240006]; Hacettepe University Scientific Research Project UnitHacettepe University [013 D04 602 004]; Turkish Academy of Sciences (TUBA)Turkish Academy of Sciencesen_US
dc.description.sponsorshipThe authors acknowledge the "Ankara University, Scientific Research Unit" Grant No. 09B4240006. T. H. is grateful to Hacettepe University Scientific Research Project Unit (Grant No. 013 D04 602 004) and Z. K. thanks to Turkish Academy of Sciences (TUBA) for partial support of this work.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s10973-015-5001-6
dc.identifier.endpage1641en_US
dc.identifier.issn1388-6150
dc.identifier.issn1588-2926
dc.identifier.issue2en_US
dc.identifier.startpage1627en_US
dc.identifier.urihttps://doi.org/10.1007/s10973-015-5001-6
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6642
dc.identifier.volume123en_US
dc.identifier.wosWOS:000368199500073
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Thermal Analysis And Calorimetry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhosphazene saltsen_US
dc.subjectThermal analysisen_US
dc.subjectCytotoxic activityen_US
dc.subjectDNA bindingen_US
dc.subjectAntimicrobial activityen_US
dc.titlePhosphorus-nitrogen compounds Part 32. Structural and thermal characterizations, antimicrobial and cytotoxic activities, and in vitro DNA binding of the phosphazenium saltsen_US
dc.typeArticle

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