The Healing Effects of The Topical Mesenchymal Stem Cell Application on Colonic Anastomosis Subjected to Ischemia Reperfusion Injury

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dc.contributor.authorOzden, Huseyin
dc.contributor.authorKaraca, Gokhan
dc.contributor.authorBulut, Huri
dc.contributor.authorNiyaz, Mehmet
dc.contributor.authorGomec, Muhammed
dc.contributor.authorDaphan, Cagatay E.
dc.date.accessioned2025-01-21T16:45:34Z
dc.date.available2025-01-21T16:45:34Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIntestinal ischemia reperfusion injury (IRI) is a challenging problem and it adversely affects the healing of colonic anastomosis. Our experimental study aimed to investigate the role of mesenchymal stem cells (MSC) administration in the healing of colonic anastomosis. A total of 33 rats were grouped as Control, IRI and MSC treatment groups. Three rats were reserved for obtaining MSCs. Colonic resection and anastomosis procedure was performed in all groups. Anastomotic line was wrapped with MSCs impregnated spongostan after colonic anastomosis in the rats of the MSC treatment group. All rats were sacrificed and anastomotic line were sampled for examination on the post operative seventh day. Tissue hydroxyproline (HP) levels and anastomotic bursting pressures were statistically compared. Anastomotic bursting pressures were found to be significantly high in MSC treatment group rats. The lowest anastomotic bursting pressure was detected in IRI group rats. Hydroxyproline content of the anastomotic sites were also found to be significantly higher in the rats of the MSC treatment group when compared with the IRI group rats. Our study showed that the detrimental effects of IRI on the healing process of colonic anastomosis in an experimental model may be alleviated with the treatment of MSCs.
dc.identifier.doi10.9775/kvfd.2021.25935
dc.identifier.endpage600
dc.identifier.issn1300-6045
dc.identifier.issn1309-2251
dc.identifier.issue5
dc.identifier.startpage595
dc.identifier.urihttps://doi.org/10.9775/kvfd.2021.25935
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25676
dc.identifier.volume27
dc.identifier.wosWOS:000704282200008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisi
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAnastomotic leakage; Colonic anastomosis; Hydroxyproline; ischemia reperfusion injury; Mesenchymal stem cell
dc.titleThe Healing Effects of The Topical Mesenchymal Stem Cell Application on Colonic Anastomosis Subjected to Ischemia Reperfusion Injury
dc.typeArticle

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