Evaluation of hepatokines, proinflammatory cytokines, oxidative stress and energy related metabolism analytes and hematological parameters in dairy cows with placental retention

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dc.contributor.authorBayraktar, Bülent
dc.contributor.authorKara, Erdal
dc.contributor.authorElifoğlu, Taha Burak
dc.contributor.authorKaya, Ufuk
dc.date.accessioned2025-01-21T16:16:13Z
dc.date.available2025-01-21T16:16:13Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: To investigate the serum levels of angiopoietin-like protein 4 (ANGPTL4), fibroblast growth factor 21 (FGF21), interleukin 1 beta (IL-1?), IL-6, superoxide dismutase (SOD), malondialdehyde (MDA), and energy-related metabolism analytes and hematological parameters in cows with placental retention (PR). Materials and Methods: In the presented study, blood samples were taken from the coccygeal veins of 10 cows with PR and 10 healthy control cows. All of the samples were analyzed to determine the serum glucose, unesterified fatty acid (NEFA), triglyceride, high-density lipoprotein (HDL), total protein, albumin, aspartate aminotransaminase (AST), SOD, and MDA levels. Blood serum hepatokines, ANGPTL4, FGF21 levels, proinflammatory cytokine response parameters, IL-1 beta, and IL-6 levels were evaluated. Results: As a result, the increase in serum AST (p < 0.05) indicated altered liver function. During negative energy balance, the serum NEFA levels (p < 0.05) increased, and serum HDL levels (p < 0.05) decreased as indicators of an increased risk of metabolic pathology. Increases in the serum ANGPTL4, FGF21, CRP, and SOD (p < 0.001) and IL-6, MDA, creatine kinase levels (p < 0.05) were evaluated as indicators of the development of effective metabolic, inflammatory, and oxidative stress. The monocyte count was significantly lower (p < 0.05) in the cows with PR. Conclusion: It was concluded that significant increases in the serum ANGPTL4 and FGF2 levels were associated with energy balance, effective cytokine responses, and oxidative stress in dairy cows with PR.
dc.identifier.endpage258
dc.identifier.issn1309-6958
dc.identifier.issn2146-1953
dc.identifier.issue4
dc.identifier.startpage252
dc.identifier.trdizinid492849
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/492849
dc.identifier.urihttps://hdl.handle.net/20.500.12587/22334
dc.identifier.volume37
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofEurasian Journal of Veterinary Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectBiyoloji
dc.subjectZooloji
dc.titleEvaluation of hepatokines, proinflammatory cytokines, oxidative stress and energy related metabolism analytes and hematological parameters in dairy cows with placental retention
dc.typeArticle

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