In–Vitro Anticancer and Antibacterial Activities of Brominated Indeno[1,2-b]qinoline Amines Supported with Molecular Docking and MCDM**

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dc.contributor.authorAydın, Ali
dc.contributor.authorÖkten, Salih
dc.contributor.authorErkan, Sultan
dc.contributor.authorBulut, Merve
dc.contributor.authorÖzcan, Evrencan
dc.contributor.authorTutar, Ahmet
dc.contributor.authorEren, Tamer
dc.date.accessioned2025-01-21T16:28:00Z
dc.date.available2025-01-21T16:28:00Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe present study describes mono substituted indeno[1,2-b]quinolines (3 a–c and 5) have much more antiproliferative potentials than positive controls against A549, HeLa, MCF7 and Hep3B cell lines (IC50 values 1.1–29.6 ?g/mL) and show similar cytotoxicity (14.3 % to 19.8 %) to cells such as controls. Moreover, the mono substituted indeno[1,2-b]quinoline amines (3 a–c and 5) exhibit significant antimicrobial activity with MIC values between 15.62 ?g/mL and 250 ?g/mL. The compounds can also bind to DNA in the groove binding mode with a binding constant range of 1.1×103–1.1×105 M?1. The anticancer and antibacterial properties of compounds were confirmed with the molecular docking simulation for their pharmacokinetic. As a result, the preliminary experimental data and a multi-criteria decision-making methodology (MCDM) indicated that the mono substituted indeno[1,2-b]quinoline amine derivatives, especially 3 a and 5, exhibit effective pharmacological properties. parameters and their interaction with related cells at the molecular level. © 2021 Wiley-VCH GmbH
dc.identifier.doi10.1002/slct.202004753
dc.identifier.endpage3295
dc.identifier.issn2365-6549
dc.identifier.issue13
dc.identifier.scopus2-s2.0-85107543872
dc.identifier.scopusqualityQ3
dc.identifier.startpage3286
dc.identifier.urihttps://doi.org/10.1002/slct.202004753
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23443
dc.identifier.volume6
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofChemistrySelect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAntibacterial agents; Antitumor agents; Biological activity; Indeno[1,2-b]quinoline amine; Molecular docking; Multi criteria decision making
dc.titleIn–Vitro Anticancer and Antibacterial Activities of Brominated Indeno[1,2-b]qinoline Amines Supported with Molecular Docking and MCDM**
dc.typeArticle

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