Evaluation of infants with neonatal cholestasis: Experience of a tertiary referral center in Turkey

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dc.contributor.authorGürlek Gökçebay D.
dc.contributor.authorGülerman H.F.
dc.contributor.authorArda N.
dc.contributor.authorAtavci S.
dc.date.accessioned2020-06-25T15:17:38Z
dc.date.available2020-06-25T15:17:38Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Neonatal cholestasis can be the initial evidence of a heterogeneous group of diseases of different etiologies. The aim of the study is to evaluate the patients with neonatal cholestasis and analyse the etiologic factors, diagnostic tools and outcome. Material and Methods: Seventy-five patients (65% males, 45% females) between 0-6 months of age with neonatal cholestasis were retrospectively evaluated; analysed for the clinical, laboratory, radiological, scintigraphic data and histopathological findings from liver biopsies. Results: Eighty per cent of the infants' admitted to our hospital because of prolonged jaundice. The onset of the jaundice was in the first week of life in 64% of the cases, but admission time of the referral center was median two months. Biliary atresia (BA) was determined in 21 (28%), neonatal hepatitis (NH) in 54 (72%) of the patients. Biliary atresia group had significantly more frequent acholic stool, relatively lower aspartate aminotransferase, but higher gamma-glutamyl transpeptidase, and serum protein levels. Liver biopsy and hepatobiliary scintigraphy were the most sensitive methods for differentiation BA from NH (p<0.05). During the follow-up period, 13 of the patients (18%) died, whereas cholestasis improved in 14 of the patients with NH (27%) within median 6 months. Survival rate at one year was 45.5% for the patients with BA, and 87% for the patients with NH. So patients with NH had better prognosis (p<0.05). Conclusion: It has been evident that early diagnosis and intervention of treatable causes of neonatal cholestasis have a vital importance. © 2015 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/medsci.2015-46367
dc.identifier.endpage224en_US
dc.identifier.issn13000292
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84952778726
dc.identifier.scopusqualityQ4
dc.identifier.startpage218en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2015-46367
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2459
dc.identifier.volume35en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiliary atresiaen_US
dc.subjectCholestasisen_US
dc.subjectJaundiceen_US
dc.subjectNeonatalen_US
dc.titleEvaluation of infants with neonatal cholestasis: Experience of a tertiary referral center in Turkeyen_US
dc.title.alternativeNeonatal kolestazlı infantlann değerlendirilmesi: Türkiye'den bir üçüncü basamak referans merkezinin deneyimien_US
dc.typeArticle

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