Do variations in the concentrations of EDTA and citric acid affect the release of different growth factors from the dentin matrix?

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dc.contributor.authorHançerlioğulları, Dilek
dc.date.accessioned2025-01-21T16:12:27Z
dc.date.available2025-01-21T16:12:27Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPurpose: To investigate the release levels of transforming growth factor beta-1 (TGF-?1), bone morpho- genetic protein-7 (BMP-7), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor-A (VEGF-A) from the dentin matrix using 10% and 17% ethylenediaminetetraacetic acid (EDTA) and 10% and 20% citric acid during regenerative endodontic procedures. Methods: Fifty mandibular single-rooted premolar teeth were used. 8-mm cylindrical roots were irrigat- ed with 1.5% sodium hypochlorite. Root segments were divided into groups by 20 mL of final irrigants: saline, 10% or 17% EDTA, and 10% or 20% citric acid. The samples were placed into culture medium and kept in an incubator at 37°C for 24 h. The supernatants were collected to measure the levels of growth factors with an enzyme-linked immunosorbent assay. The data were evaluated using a one-way analysis of variance. Results: EDTA or citric acid increased the release levels of all growth factors compared to the control group. The greatest amount of TGF-?1 release was measured with 17% EDTA; however, it was not sig- nificantly different from 10% citric acid. The lowest amount of BMP-7 released was with 10% citric acid, which was significantly different from the other groups. Conclusion: The 17% EDTA and 10% citric acid solutions had a similar effect on the release of growth factors from the dentin matrix.
dc.identifier.doi10.14744/TEJ.2023.8557
dc.identifier.endpage48
dc.identifier.issn2459-1726
dc.identifier.issue2
dc.identifier.startpage43
dc.identifier.trdizinid1239641
dc.identifier.urihttps://doi.org/10.14744/TEJ.2023.8557
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1239641
dc.identifier.urihttps://hdl.handle.net/20.500.12587/21714
dc.identifier.volume8
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Endodontic Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectDiş Hekimliği
dc.subjectKimya
dc.subjectTıbbi
dc.subjectBiyoteknoloji ve Uygulamalı Mikrobiyoloji
dc.subjectHücre Biyolojisi
dc.titleDo variations in the concentrations of EDTA and citric acid affect the release of different growth factors from the dentin matrix?
dc.typeArticle

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