Protective Effect of Krill Oil Against Gentamicin Induced Oxidative Stress Mediated Nephrotoxicity in Rats

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dc.contributor.authorŞahin, Yaşar
dc.contributor.authorAlçığır, Mehmet Eray
dc.contributor.authorŞenol, Ali
dc.contributor.authorÖzden, Hüseyin
dc.contributor.authorEkici, Hüsamettin
dc.contributor.authorYıldırım, Ebru
dc.contributor.authorÇınar, Miyase
dc.date.accessioned2025-01-21T16:13:34Z
dc.date.available2025-01-21T16:13:34Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThis study aimed to evaluate the protective effect of krill oil against nephrotoxicity caused by gentamicin. Distilled water was given orally to the control and second groups (GI) for seven days while 500 mg/kg krill oil was given to the third (GII), fourth (GIII) groups. In addition, isotonic saline was administered subcutaneously to the control and GIII groups throughout the study, while 80 mg/kg gentamicin was administered to the GI, and GII groups. Alanine aminotransferase (ALT) and gamma glutamyltransferase (GGT) peptidase, total cholesterol, urea, and creatinine levels in plasma and, malondialdehyde (MDA) and total antioxidant status (TAS) levels in both plasma and kidney tissue supernatant were evaluated. Histopathological changes in tubules and glomeruli and vascular changes were evaluated by scoring. Urea level and ALT activity were found to be significantly lower in the GII and GIII groups compared to the GI group (p<0.001; p?0.001). As a result, it was observed that degenerative damage and glomerular changes in the tubule at the histological level mediated by oxidative stress were consistent with the increase in ALT, urea, and MDA levels. In this respect, it is suggested that krill oil can be used as a nephroprotective food supplement to contribute to treatment in cases of toxicity.
dc.identifier.doi10.30607/kvj.1051733
dc.identifier.endpage46
dc.identifier.issn1308-1594
dc.identifier.issn2147-6853
dc.identifier.issue1
dc.identifier.startpage38
dc.identifier.trdizinid510003
dc.identifier.urihttps://doi.org/10.30607/kvj.1051733
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/510003
dc.identifier.urihttps://hdl.handle.net/20.500.12587/21944
dc.identifier.volume15
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofKocatepe Veterinary Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectBiyoloji
dc.subjectToksikoloji
dc.subjectVeterinerlik
dc.titleProtective Effect of Krill Oil Against Gentamicin Induced Oxidative Stress Mediated Nephrotoxicity in Rats
dc.typeArticle

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