Investigation of Glutathione S-Transferase-Alpha and Glutathione S-Transferase-Pi Expression Levels in Spermophilus xanthoprymnus and Meriones tristrami in Terms of Living Conditions and Natural Habitat Differences in Kırıkkale Province

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dc.contributor.authorPamukoğlu, Nahit
dc.contributor.authorOğuztüzün, Serpil
dc.contributor.authorDirican, Onur
dc.contributor.authorSarıaltın, Sezen Yılmaz
dc.date.accessioned2025-01-21T16:14:06Z
dc.date.available2025-01-21T16:14:06Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractGlutathione S-transferase (GST) is a multifunctional enzyme that provides homeostasis by catalyzing the first step in the formation of the end product mercapturic acid in the detoxification metabolic pathway. Being found in mammals, insects, fish, birds, annelids, molluscs, and many microorganisms, GST takes part the elimination of toxic substances taken into body by consuming food, and their transport by binding non-substrate ligands (e.g. heme and bilirubin) with GSH. In addition, it can prevent reactive electrophilic compounds from harming the body by covalent bonding similar compounds to each other. These xenobiotic acceptors affected by GST include nitrogen halogen compounds, organophosphates, and polycyclic aromatic hydrocarbons. Xenobiotics are oxygenated by this enzyme system, the next mechanism of oxygenated products is more oxygenation, and these products become more easily soluble in water. In this study, Glutathione S-Transferase was detected in the liver tissue of Spermophilus xanthoprymnus and Meriones tristrami and its characteristic features were determined. For this purpose, the animals were anesthetized with sodium pentobarbital and their liver tissues were harvested. After necessary preparations were completed, the samples were analyzed by using immunohistochemical staining method and the expressions of GST isozymes were determined. As a result, glutathione s-transferase-alpha and glutathione s-transferase-pi expression levels were found to differ in Spermophilus xanthoprymnus and Meriones tristrami samples obtained from different localities of Kırıkkale province. Differences in GST enzyme expression in these species indicate that both species differ in their detoxification capacity and response to xenobiotics.
dc.identifier.doi10.24180/ijaws.1315843
dc.identifier.endpage459
dc.identifier.issn2149-8245
dc.identifier.issue3
dc.identifier.startpage448
dc.identifier.trdizinid1214950
dc.identifier.urihttps://doi.org/10.24180/ijaws.1315843
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1214950
dc.identifier.urihttps://hdl.handle.net/20.500.12587/22071
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofUluslararası Tarım ve Yaban Hayatı Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectMikroskopi
dc.subjectBiyoloji
dc.subjectMikrobiyoloji
dc.subjectÇevre Bilimleri
dc.subjectTıbbi Laboratuar Teknolojisi
dc.titleInvestigation of Glutathione S-Transferase-Alpha and Glutathione S-Transferase-Pi Expression Levels in Spermophilus xanthoprymnus and Meriones tristrami in Terms of Living Conditions and Natural Habitat Differences in Kırıkkale Province
dc.typeArticle

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