Effects of mesenchymal stem cells to prevent adhesions for vascular reoperations: An experimental study

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dc.contributor.authorKabalcı, Mehmet
dc.contributor.authorZengin, Mehmet
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorKısa, Üçler
dc.date.accessioned2021-01-14T18:22:00Z
dc.date.available2021-01-14T18:22:00Z
dc.date.issued2019
dc.description.abstractObjectives: In the present study, we aimed to investigate whether mesenchymal stem cells (MSCs) were useful to reduce cutaneous adhesions, particularly for vascular reoperations. Materials and methods: In this experimental study, 12 adult male Wistar Albino rats were used. In Group 1 (n=2, negative control group), no incision was performed. In Group 2 (n=5, positive control group), skin and subcutaneous tissues were incised. In Group 3 (n=5, MSC group), skin and subcutaneous tissues were incised and 3×106 MSCs were applied. Macroscopic scoring of adhesion and histopathological scoring of tissue repair response were evaluated. Results: Macroscopic view of the adhesion values (Padjusted <0.0175), histopathological evaluation values (histiocytic response, vascularization, and granulocytic response and total response) (Padjusted <0.0175), and collagen deposit values (Padjusted <0.0175) of Group 3 were significantly lower than Group 2. Conclusion: Our study results suggest that the use of MSCs seems to be useful to prevent adhesion formation in cutaneous injuries and that MSCs promote wound healing without adhesions in the experimental setting.en_US
dc.identifier.doi10.9739/tjvs.2019.560
dc.identifier.endpage185en_US
dc.identifier.issn2667-4947
dc.identifier.issn2667-5080
dc.identifier.issue3en_US
dc.identifier.startpage180en_US
dc.identifier.trdizinid360411
dc.identifier.urihttps://doi.org/10.9739/tjvs.2019.560
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpZd05ERXhNUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12587/13978
dc.identifier.volume28en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish journal of vascular surgery
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffects of mesenchymal stem cells to prevent adhesions for vascular reoperations: An experimental studyen_US
dc.typeArticle

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