The effect of smoking on platelet reactivity assessed by p2y12 platelet function testing in patient with clopidogrel therapy

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dc.contributor.authorSarak, Taner
dc.contributor.authorSarıçam, Ersin
dc.contributor.authorRad, Abbas Yousefi
dc.date.accessioned2025-01-21T16:17:07Z
dc.date.available2025-01-21T16:17:07Z
dc.date.issued2020
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: The interaction between cigarette smoking and efficacy of platelet function testing is not definitely shown. We aimed to investigate the effects of smoking on platelet reactivity by P2Y12 platelet function testing on the patients treated with clopidogrel. Material and Method: This prospective study contained 200 patients who underwent a previous stent implantation. Diagnostic coronary angiography was performed those patients due to chest pain. The clopidogrel resistance test was applied. Furthermore, the smoking effect on platelet reactivity was investigated. Then stent restenosis rates were investigated. Results: We found that 17% of the patients (34/200) clopidogrelresistant by P2Y12 platelet function test. We didn’t find any relationship between angiographic stent restenosis and clopidogrel resistance (p>0.05). There was statistically significant relationship between smoking and clopidogrel resistance. The smokers had also higher platelet reactivity level (>208 PRUs) as revealed by VerifyNow P2Y12 assay. Discussion: The test results achieved through the clopidogrel resistance by P2Y12 platelet function testing did not meet expectation with the angiographically observations. Conclusion: P2Y12 platelet function testing can be unclear in smoker patients.
dc.identifier.doi10.32322/jhsm.654901
dc.identifier.endpage46
dc.identifier.issn2636-8579
dc.identifier.issue1
dc.identifier.startpage42
dc.identifier.trdizinid485503
dc.identifier.urihttps://doi.org/10.32322/jhsm.654901
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/485503
dc.identifier.urihttps://hdl.handle.net/20.500.12587/22561
dc.identifier.volume3
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJournal of health sciences and medicine (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectGenel ve Dahili Tıp
dc.titleThe effect of smoking on platelet reactivity assessed by p2y12 platelet function testing in patient with clopidogrel therapy
dc.typeArticle

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