Protective Effect of Silymarin and Boric Acid Against Isoproterenol-Induced Myocardial Infarction in Mice

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dc.contributor.authorŞahin, Yaşar
dc.contributor.authorAlçığır, Mehmet Eray
dc.contributor.authorBakar-Ateş, Filiz
dc.contributor.authorEkici, Hüsamettin
dc.contributor.authorŞenol, Ali
dc.contributor.authorAtıcı, Enes Gazi
dc.contributor.authorYıldırım, Ebru
dc.date.accessioned2025-01-21T16:11:31Z
dc.date.available2025-01-21T16:11:31Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThis study aimed to compare the protective effects of separate and combined use of silymarin and boric acid against myocardial infarction induced by isoproterenol. Distilled water was given orally by gavage to the GI and GII groups for fourteen days. The GIII group was received silymarin (100 mg/kg), while the GIV group was given boric acid (100 mg/kg) for 14 days. In the last group, both silymarin and boric acid were given orally (gavage) for fourteen days. On the thirteenth and fourteenth days of the study, while isotonic water was applied to the GI group, isoproterenol (85 mg/kg) was applied to the other groups subcutaneously. Plasma ALT, AST, Ca, CK, CHO, TP, Ing P, IL-6, IL-12, PAL-1, and sPLA2 parameters were evaluated. Histopathological examination was performed on the heart, lung, liver, kidney, spleen, cerebrum, and cerebellum tissues taken from mice. The CK level was found to be significantly lower in the GIII and GV groups compared to the GII group (P<0.05). As a result, the increases shown in the plasma AST and CK activities caused due to the myocardial damage induced by isoproterenol were decreased in the silymarin and boric acid applied groups. Therefore it was thought that silymarin and boric acid may contribute to protection against myocardial infarction.
dc.identifier.doi10.35864/evmd.1091140
dc.identifier.endpage33
dc.identifier.issn1016-3573
dc.identifier.issue1
dc.identifier.startpage26
dc.identifier.trdizinid1156927
dc.identifier.urihttps://doi.org/10.35864/evmd.1091140
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1156927
dc.identifier.urihttps://hdl.handle.net/20.500.12587/21512
dc.identifier.volume33
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofEtlik Veteriner Mikrobiyoloji Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectBiyoloji
dc.subjectGenel ve Dahili Tıp
dc.subjectPatoloji
dc.subjectOnkoloji
dc.subjectVeterinerlik
dc.subjectKalp ve Kalp Damar Sistemi
dc.titleProtective Effect of Silymarin and Boric Acid Against Isoproterenol-Induced Myocardial Infarction in Mice
dc.typeArticle

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