Novel prognostic markers associated with poor survival in stage III rectal cancers: Invasive growth pattern and Tumor necrosis

Basit Öğe Kaydı
dc.contributor.authorZengin, Mehmet
dc.date.accessioned2025-01-21T16:19:27Z
dc.date.available2025-01-21T16:19:27Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: Rectal carcinomas (RC) are one of the most common cancers in the Western World. TNM system is the most significant predictive indicator in these tumors but patients characterized by the same stage often have prominent distinct survival. In this research, we analyzed the survival effect of Invasive growth pattern (IGP) and Tumor necrosis (TN) in stage III RC.Material and Methods: A hundred forty-five patients operated for stage III RC during 1999-2012 at Kırıkkale University were included in this research. These parameters were scored on hematoxylin and eosin stained sections. The relationship between the results and the clinicopathological characteristics was analyzed.Results: These parameters were significantly upregulated in RCs which classified as higher tumor size (IGP: p<0.001; TN: p=0.033), higher pT (IGP: p=0.016; TN: p=0.047), angiolymphatic invasion (IGP: p=0.025), high number of metastatic lymph nodes (IGP: p<0.001; TN: p=0.001), advanced stage (IGP: p<0.001; TN: p=0.018), and advanced grade (IGP: p<0.001). In univariate analysis, patients with these two parameters had worse 5-year survivals ([IGP= RFS: 50%, p=0.001; OS=55%, p=0.003], [TN= RFS: 53%, p=0.005; OS: 58%, p=0.017]). Multivariate analyzes confirmed that these two parameters are independent worse survival parameters for RFS (IGP=Hazard ratio [HR]: 1.58 [1.05-2.66], p=0.005; TN=1.44 [1.07–2.34], p=0.013) and OS (IGP=HR: 1.55 [1.11–3.18], p=0.008; TN= 1.38 [1.09–2.28], p=0.024). In addition, IGP was found to be more successful than TN.Conclusion: Our data suggest that IGP and TN provide valuable prognostic information for RC, and adding these parameters to the current risk classification may contribute to better patient selection.
dc.identifier.doi10.18663/tjcl.572566
dc.identifier.endpage376
dc.identifier.issn2149-8296
dc.identifier.issue3
dc.identifier.startpage369
dc.identifier.trdizinid415160
dc.identifier.urihttps://doi.org/10.18663/tjcl.572566
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/415160
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23085
dc.identifier.volume10
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Clinics and Laboratory
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectGenel ve Dahili Tıp
dc.subjectPatoloji
dc.subjectOnkoloji
dc.titleNovel prognostic markers associated with poor survival in stage III rectal cancers: Invasive growth pattern and Tumor necrosis
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu