Analysis of estrogen and progesterone receptors in lesional and normal skin of patients with acne rosacea
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Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Giriş: Rozase etyolojisinde hormonal faktörlerin rol oynayabileceğine ilişkin çok sayıda kanıt bulunmaktadır. Lezyonel deride östrojen reseptörlerinin azalması ve progesteron reseptörlerinin artışı hipotetik olarak rozase oluşumunda önemli olabilir. Amaç: Bu çalışmada rozaseli hastaların lezyonel ve normal deri dokularında östrojen ve progesteron reseptörlerinin ekspresyonunun saptanması amaçlanmıştır. Hastalar ve Yöntem: Bu amaçla rozaseli 20 hastanın lezyonel deri örneklerinde ve gönüllü 5 hastanın nonlezyonel deri örneklerinde immünhistokimyasal metod ile östrojen ve progesteron reseptörleri çalışılmıştır. Bulgular: Lezyonel deri biyopsilerinden 2'sinde (10%) progesteron reseptör varlığı saptanmış, ancak hiç bir örnekte östrojen reseptörleri gösterilememiştir. Sonuç: Bu bulgular rozase etyolojisinde östrojen ve progesteron reseptörlerinin önemi hipotezini desteklememekle birlikte bloklanamayan/ karşı konulamayan androjenik uyarı hipotezinin araştırılması gerektiğini düşündürmektedir.
Background: There is a plenty of clinical evidence suggesting that rosacea may be a hormonally mediated disorder. Hypothetically, an overexpression of progesterone receptors, in conjunction with a reduced expression of estrogen receptors within the lesionalskin might play a role in the development of rosacea. Objective: The aim of the present study was to evaluate the expression of estrogen and progesterone receptors in Iesional and uninvolved skin of patients with rosacea. Methods: For this purpose 20 lesional cutaneous biopsies and 5 non-lesional cutaneous biopsies from patients with rosacea were studied by immunohistochemical method for the expression of estrogen and progesterone receptors. Results: Immunohistochemical examination showed that 2 (10%) of the 20 lesional biopsy specimens expressed progesterone receptors. None of the lesional biopsy samples expressed estrogen receptors. Conclusion: Although these findings fail to provide presumptive evidence for a role of estrogen and progesterone receptors in rosacea, there remains the possibility that unopposed androgenic stimulation might be involved in the etiopathogenesis of rosacea.
Background: There is a plenty of clinical evidence suggesting that rosacea may be a hormonally mediated disorder. Hypothetically, an overexpression of progesterone receptors, in conjunction with a reduced expression of estrogen receptors within the lesionalskin might play a role in the development of rosacea. Objective: The aim of the present study was to evaluate the expression of estrogen and progesterone receptors in Iesional and uninvolved skin of patients with rosacea. Methods: For this purpose 20 lesional cutaneous biopsies and 5 non-lesional cutaneous biopsies from patients with rosacea were studied by immunohistochemical method for the expression of estrogen and progesterone receptors. Results: Immunohistochemical examination showed that 2 (10%) of the 20 lesional biopsy specimens expressed progesterone receptors. None of the lesional biopsy samples expressed estrogen receptors. Conclusion: Although these findings fail to provide presumptive evidence for a role of estrogen and progesterone receptors in rosacea, there remains the possibility that unopposed androgenic stimulation might be involved in the etiopathogenesis of rosacea.
Açıklama
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Dermatoloji
Kaynak
Türkiye Klinikleri Dermatoloji Dergisi
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Cilt
13
Sayı
1
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