Effect of the tunneled-cuffed central venous catheters on oxidative stress indices and inflammation in chronic hemodialysis patients

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dc.contributor.authorKorucu, Berfu
dc.contributor.authorYeter, Hacı Hasan
dc.contributor.authorBali, Elif Burcu
dc.contributor.authorDerici, Mehmet Kürşat
dc.date.accessioned2025-01-21T16:17:07Z
dc.date.available2025-01-21T16:17:07Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: The use of central venous catheters as hemodialysis (HD) vascular access is associated with worse\rmorbidity and mortality in HD patients. This occasion is often attributed to comorbidities of the patients with\rcentral venous catheters. Studies reveal that a biofilm layer occurs on most of the tunneled-cuffed central\rvenous catheters (TC-CVCs). This study aimed to determine the oxidative stress (OS) and systemic\rinflammation (SI) status in patients with TC-CVCs as HD vascular access without clinical signs and symptoms\rof infection.\rMethods: The study is composed of eighty-five patients with a minimum HD vintage of one year. Patients\rwith a history of infection or a cardiovascular event within six months, malignancy, systemic inflammatory\rdiseases, or malnutrition were excluded. OS indices and SI markers were studied and compared in patients\rwith arteriovenous fistula (AVF) and TC-CVCs.\rResults: Mean native thiol/total thiol (NT/TT) ratio was significantly higher and mean disulphide/total thiol\r(DT/TT) ratio was significantly lower in AVF group comparing TC-CVC group (0.46 ± 0.17 and 0.36 ± 0.17,\rp = 0.03 for NT/TT; 0.27 ± 0.08 and 0.31 ± 0.08, p = 0.04 for DS/TT; respectively). Mean OS index was\rsignificantly lower in the AVF group comparing TC-CVC group (0.15 ± 0.14 and 0.24 ± 0.23, p = 0.04;\rrespectively]. Median hs-CRP levels and median IL-6 levels were significantly lower in AVF group comparing\rTC-CVC group (5.8 [min: 3.0-max: 82.5] mg/L and 9.7 [min: 3.0-max: 45.4] mg/L, p = 0.004 for hs-CRP; 6.2\r[min: 2.0-max:159.0] pg/mL and 12.2 [min: 2.6-max: 41.3) pg/mL, p = 0.01 for IL-6; respectively).\rConclusions: TC-CVCs inversely affect OS and systemic inflammatory status in HD patients, presumably\rdue to foreign body reactions and biofilm layers.
dc.identifier.doi10.18621/eurj.698967
dc.identifier.endpage135
dc.identifier.issn2149-3189
dc.identifier.issue2
dc.identifier.startpage127
dc.identifier.trdizinid536357
dc.identifier.urihttps://doi.org/10.18621/eurj.698967
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/536357
dc.identifier.urihttps://hdl.handle.net/20.500.12587/22560
dc.identifier.volume7
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofThe European Research Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectGenel ve Dahili Tıp
dc.titleEffect of the tunneled-cuffed central venous catheters on oxidative stress indices and inflammation in chronic hemodialysis patients
dc.typeArticle

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