An Investigation into Hematoprotective and Antioxidant Effects of Salvia virgata Jacq. Upon Cyclophosphamide-Induced Toxicity

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dc.contributor.authorSahin, İlknur Kulcanay
dc.date.accessioned2025-01-21T16:11:20Z
dc.date.available2025-01-21T16:11:20Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe present study aims to investigate hematoprotective and antioxidant effects of Salvia virgata (SV) on Cyclophosphamide (CP)-induced toxicity. The rats were divided into 6 groups of 7 members each. These were the Control group, CP Group (150 mg kg-1), 100 and 200 mg kg-1 SV Groups, and CP+100 and CP+200 mg kg-1 SV Groups. All the rats were sacrificed to harvest their blood and bone marrow samples the day after final injections. While some of the blood samples were used for leukocyte and platelet count, the others were used to determine the levels of total antioxidant capacity (TAC), malondialdehyde (MDA), total oxidant status (TOS), glutathione (GSH), and oxidative stress index (OSI). While a decrease was observed in the leukocyte, platelet and bone-marrow nucleated cell counts of the group given CP, apart from a decline in GSH and TAC levels, the MDA and TOC levels of the rats in this group showed an increase. In contrast, CP-induced oxidative stress and myelosuppression reversed in the combined SV Groups (CP+100 and 200 mg kg-1 of SV Groups), although the reversal in the latter group was of more significance. Our experimental results have shown that SV may exert antioxidant and cytoprotective effects upon CP-related peripheral blood and bone marrow toxicities.
dc.identifier.doi10.21597/jist.1007441
dc.identifier.endpage596
dc.identifier.issn2146-0574
dc.identifier.issn2536-4618
dc.identifier.issue2
dc.identifier.startpage589
dc.identifier.trdizinid527822
dc.identifier.urihttps://doi.org/10.21597/jist.1007441
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/527822
dc.identifier.urihttps://hdl.handle.net/20.500.12587/21463
dc.identifier.volume12
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofIğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectHematoloji
dc.subjectKimya
dc.subjectTıbbi
dc.subjectİmmünoloji
dc.subjectFarmakoloji ve Eczacılık
dc.titleAn Investigation into Hematoprotective and Antioxidant Effects of Salvia virgata Jacq. Upon Cyclophosphamide-Induced Toxicity
dc.typeArticle

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