Gross tumour volume and poorly differentiated clusters can indicate high-risk patients for poor survival in pT1-2 rectal carcinomas

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dc.contributor.authorZengin, Mehmet
dc.contributor.authorAtasoy, Pınar
dc.date.accessioned2025-01-21T16:19:30Z
dc.date.available2025-01-21T16:19:30Z
dc.date.issued2020
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: Colorectal carcinomas are one of the most common carcinomas in the Western world. Survival is mainly associated with the tumournode-metastasis (TNM) stage but patients with the same tumour stage usually show marked distinct survival. We analyzed the survival effect of gross tumour volume and poorly differentiated clusters in pT1-2 rectal carcinomas. Material and Method: Sixty-five pT1-2 rectal carcinomas that were curatively resected between 1999 and 2014 were included in this retrospective study at Kırıkkale University Medical Faculty Hospital. Gross tumour volume and poorly differentiated clusters were scored using a macroscopic specimen and hematoxylin and eosin-stained sections. Results: These parameters were significantly associated with large tumour size (gross tumour volume [GTV]: p=0.020), invasive pattern (GTV: p=0.004; poorly differentiated clusters [PDC]: p=0.020), angiolymphatic invasion (GTV: p=0.001; PDC: p=0.009), tumour necrosis (GTV: p=0.002; PDC: p=0.038), and high grade (PDC: p=0.001). In univariate analysis, patients with these parameters had worse 5-year survival for both relapse-free survival (RFS) and overall survival (OS) ([GTV: RFS= 78.5%, p=0.001; OS: 81.0%, p=0.005], [PDC: RFS= 80.0%, p=0.013; OS: 83.1%, p=0.039]). Multivariate analysis confirmed that these parameters are independent predictors of poor survival for RFS (GTV: Hazard ratio [HR]=1.42 [1.06-2.85], p=0.006; PDC: HR=1.39 [1.06-3.28], p=0.028) and OS (GTV: HR=1.35 [1.09-3.37], p=0.011). Also, GTV was found to be more useful than PDC. Conclusions: According to our study, GTV and PDC play an important role in the prognosis of rectal carcinomas and the addition of these markers to the current risk classification may contribute to better patient selection.
dc.identifier.doi10.32322/jhsm.634367
dc.identifier.endpage202
dc.identifier.issn2636-8579
dc.identifier.issue3
dc.identifier.startpage196
dc.identifier.trdizinid500971
dc.identifier.urihttps://doi.org/10.32322/jhsm.634367
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/500971
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23096
dc.identifier.volume3
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJournal of health sciences and medicine (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectPatoloji
dc.subjectOnkoloji
dc.subjectİstatistik ve Olasılık
dc.titleGross tumour volume and poorly differentiated clusters can indicate high-risk patients for poor survival in pT1-2 rectal carcinomas
dc.typeArticle

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