Does Saccharin Have Effects on Appetite, Energy Intake, And Serum Ghrelin? A Randomized, Controlled, Cross- Over Study in Healthy Males
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Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Instead of sugar, artificial sweeteners that do not contain energy are widely used. However, contrary to popular belief, artificial sweeteners are thought to affect metabolism. Thus, purpose of this present study was to evaluate effects of saccharin on serum ghrelin, appetite, and food consumption. Methods: Nine healthy males aged 20-29 participated in the randomized, controlled, and cross-over study. Each participant received 300 ml water, and 300 ml water containing 75 grams sucrose and 240 milligrams saccharin. At baseline, 30th, 60th, 90th, 120th, and 180th min, Visual Analog Scale was applied to evaluate appetite, and blood samples were taken to analyze ghrelin. After 180th min, participants consumed ad libitum diet, and kept 24-hours dietary food intake records until the end of this day. Results: At 60th and 120th min, mean ghrelin level was higher in drinks containing only water and saccharin compared to drink containing sucrose (p=0.001, p=0.003 respectively). In addition, in 90th min following drink consumption, mean ghrelin level was higher in drink containing saccharin than sucrose test drink (p=0.001). Mean prospective food consumption and desire to eat score at 120th min after drink consumption was higher in saccharin test drink than sucrose test drink (p<0.05). Difference between energy and macronutrient intake was statistically insignificant (p>0.05). Conclusions: In this study, which examined the effect of acute intake of saccharin an artificial sweetener, it is remarkable that high ghrelin levels and high scores related to appetite in some intervals after drink consumption containing saccharin. However, studies on the longer-term consumption of saccharin are needed to clarify these effects on appetite metabolism
Açıklama
Anahtar Kelimeler
Beslenme ve Diyetetik, Fizyoloji
Kaynak
KONURALP TIP DERGİSİ
WoS Q Değeri
Scopus Q Değeri
Cilt
14
Sayı
2
