The predictive value of bleeding score on the diagnosis of Von Willebrand disease in children applied to the hematologic clinic with epistaxis

Basit Öğe Kaydı
dc.contributor.authorAlpcan, Ayşegül
dc.contributor.authorTursun, Serkan
dc.contributor.authorKandur, Yaşar
dc.contributor.authorYörgüç, Mustafa Çağlar
dc.contributor.authorAlbayrak, Meryem
dc.date.accessioned2025-01-21T16:12:15Z
dc.date.available2025-01-21T16:12:15Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: Epistaxis may be a symptom of an inherited bleeding disease.. We aimed to analyze an approved pediatric bleeding score (PBS) as a screening test for von Willebrand Disease (VWD) in children with epistaxis Material and Method: We retrospectively reviewed the medical records of pediatric patients, who applied to the Pediatric Hematology Department with the complaint of epistaxis between January 2018 and December 2019. Results: One hundred and sixty eight patients enrolled in this study There were 65(38.7%) girls and 103(61.3%) boys, with a mean age of 114±49 months (range 8 months to 18 years).The PBS of 34 patients was greater than/ or equal to 2. Factor 8, von Willebrand factor antigen, and von Willebrand Ristocetin cofactor levels were significantly lower in patients with PBS?2 compared to those in patients with PBS<2 (%73±43 vs % 91±29, p=0.03; 87±44 vs 106±29 IU/dl, p=0.03; 72±39 vs 98±30 IU/ dl, p=0.001, respectively). While 15 (44%) of 34 patients with PBS ? 2 diagnosed VWD, but in the group with PBS<2, VWD was diagnosed for only 4 children (0.02%) (4/134). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of PBS for diagnosis of VWD was 79.0%, 87.2%, 44%, and 97% respectively. Conclusion: PBS could be integrated into the evaluation of children suspected of having a bleeding disorder such as VWD in pediatrician’s offices. Our cut off value 2 appears to be significant in exclusion of VWD, since its high negative predictive value.
dc.identifier.doi10.32322/jhsm.984860
dc.identifier.endpage25
dc.identifier.issn2636-8579
dc.identifier.issue1
dc.identifier.startpage22
dc.identifier.trdizinid1155240
dc.identifier.urihttps://doi.org/10.32322/jhsm.984860
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1155240
dc.identifier.urihttps://hdl.handle.net/20.500.12587/21667
dc.identifier.volume5
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJournal of health sciences and medicine (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectTıbbi İnformatik
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectParazitoloji
dc.subjectHematoloji
dc.subjectSağlık Bilimleri ve Hizmetleri
dc.subjectPediatri
dc.titleThe predictive value of bleeding score on the diagnosis of Von Willebrand disease in children applied to the hematologic clinic with epistaxis
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu