Can Thiol/Disulphide Homeostasis Help in The Differential Diagnosis of Appendicitis in Children?

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dc.contributor.authorDemir, Sabri
dc.contributor.authorGünal, Yasemin Dere
dc.contributor.authorÖzmen, İsmail
dc.contributor.authorBadem, Nermin Dindar
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorErel, Özcan
dc.date.accessioned2025-01-21T16:17:24Z
dc.date.available2025-01-21T16:17:24Z
dc.date.issued2020
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: We aimed to investigate the potential of assessing thiol/disulfide homeostasis as novel oxidative stressmarkers to improve the challenging diagnosis of acute appendicitis in children.Material and Methods: A total of 60 pediatric patients (0-18 years) were enrolled in the study, 30 of which were inthe control group and 30 in the acute appendicitis group. Native thiol, total thiol, dynamic disulfide, dynamic thiol,ischemia modified albümin, albumin, White blood cell, hemoglobin, hematocrit, and platelet counts of both groups weremeasured. The results of both groups were compared using the SPSS (Statistical Package for Social Sciences) version17 (Chicago, USA) program. For all variables, p <0.05 was considered significant.Results: Total thiol (p<0.001), native thiol (p<0.001), and albümin (p<0.001) levels were significantly decreased whiledynamic disulfide, dynamic thiol (p=0.003), and ischemia modified albümin (p<0.001) levels those indicating oxidantside were increased in acute appendicitis group compared to control. White blood cell counts in acute appendicitisgroup were higher (p<0.001), and platelet counts were lower (p=0.03) than the control group.Conclusion: In the differential diagnosis of acute appendicitis, especially in case that are difficult to diagnose, besides aphysical examination, imaging, and current laboratory tests, quantification of thiol/disulfide homeostasis may be helpfulin diagnosing. In addition, evaluating albumin and IMA levels may increase the specificity of the test. This test can bemore helpful in cases diagnosis is difficult such as children small in their ages and mental retardation.
dc.identifier.doi10.12956/tchd.627936
dc.identifier.endpage243
dc.identifier.issn1307-4490
dc.identifier.issn2148-3566
dc.identifier.issue3
dc.identifier.startpage236
dc.identifier.trdizinid432410
dc.identifier.urihttps://doi.org/10.12956/tchd.627936
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/432410
dc.identifier.urihttps://hdl.handle.net/20.500.12587/22629
dc.identifier.volume14
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTürkiye Çocuk Hastalıkları Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectGenel ve Dahili Tıp
dc.subjectYoğun Bakım
dc.subjectTıp
dc.subjectPediatri
dc.titleCan Thiol/Disulphide Homeostasis Help in The Differential Diagnosis of Appendicitis in Children?
dc.typeArticle

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