TİP 2 diyabetli hastalarda aköz ve serum apolipoproten A1 ve B seviyelerinin diyabetik retinopati ile korelasyonu
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Dosyalar
Tarih
2015
Yazarlar
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Yayıncı
Kırıkkale Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Serum ve aköz apolipoprotein (Apo) A1, Apo B değerleri ve Apo B/A1 oranı ile diyabetik retinopati şiddeti arasındaki ilişkiyi değerlendirmek Gereç ve Yöntem: 60 tip 2 diabetes mellituslu hasta ve 61 kontrol hastası çalışmaya alındı. Serum ve aköz Apo A1, Apo B değerleri ve Apo B/A1 oranları karşılaştırıldı. Yaş, diyabet süresi, hipertansiyon (HT), açlık kan şekeri, HbA1c, serum lipid profili, makula kalınlık ölçümleri ile diyabetik retinopati arasındaki ilişki değerlendirildi. Bulgular: Çalışmaya katılan hastaların ortalama diyabet süresi 14.12±7.30 yıldı. Diyabetik hasta grubu ve kontrol grubu arasında serum Apo A1, Apo B değerleri, serum Apo B/A1 oranı ve aköz Apo A1 değerleri arasında fark yoktu (P>0.05). Aköz sıvıda Apo B saptanması kontrol grubunda %4.9; diyabetik hasta grubunda %61.7 idi. Aközde Apo B saptanan hastalarda diyabetik retinopati şiddeti daha fazlaydı (P<0.05). Şiddetli NPDR ve PDR'si olan tüm hastalarda aköz sıvıda Apo B saptandı. Diyabetik hasta grubunda diyabetik retinopati şiddeti arttıkça serum ve aköz Apo B/A1 oranları artmaktaydı(P<0.05). Sonuç: Diyabetik retinopatili hastalarda serum ve aköz Apo B/A1 oranı diyabetik retinopati şiddetiyle ilişkili olabilir. Diyabet regülasyonunda lipid parametreleri göz önünde bulundurulabilir.
Purpose: To determine the relation between serum and aqueous levels of Apo A1, Apo B and Apo B/A1 and the severity of diabetic retinopathy. Materials and methods: Sixty patients with tip 2 diabetes and 61 patients as controls were included in the study. Serum and aqueous levels of Apo A1, Apo B and Apo B/A1 were measured. Any correlation between age, diabetes duration, hypertension, fasting blood glucose level, glycohemoglobin level, serum lipid markers and macular thickness with diabetic retinopathy were also determined. Results: The mean duration of diabetes was 14.12±7.30 years. There was no significant differences between diabetic patients and control group for serum Apo A1 and Apo B, serum apo B/A1 and the level of aqueous Apo A1(P>0.05). Apo B level was measured as 4.9% in control group and 61.7% of diabetic patients in aqueous samples. Diabetic patients with Apo B in the aqueous had more severe diabetic retinopathy (P<0.05). Apo B levels were determined in all of the severe NPDR and PDR patients in aqueous samples. As the severity of diabetic retinopathy increased in diabetic patients, the aqueous and serum Apo B / A1 were also increased (P<0.05). Conclusion: The serum and aqueous Apo B/A1 ratio may contribute to the severity of diabetic retinopathy in patients with DRP. Lipid markers may take part in the regulation of diabetes.
Purpose: To determine the relation between serum and aqueous levels of Apo A1, Apo B and Apo B/A1 and the severity of diabetic retinopathy. Materials and methods: Sixty patients with tip 2 diabetes and 61 patients as controls were included in the study. Serum and aqueous levels of Apo A1, Apo B and Apo B/A1 were measured. Any correlation between age, diabetes duration, hypertension, fasting blood glucose level, glycohemoglobin level, serum lipid markers and macular thickness with diabetic retinopathy were also determined. Results: The mean duration of diabetes was 14.12±7.30 years. There was no significant differences between diabetic patients and control group for serum Apo A1 and Apo B, serum apo B/A1 and the level of aqueous Apo A1(P>0.05). Apo B level was measured as 4.9% in control group and 61.7% of diabetic patients in aqueous samples. Diabetic patients with Apo B in the aqueous had more severe diabetic retinopathy (P<0.05). Apo B levels were determined in all of the severe NPDR and PDR patients in aqueous samples. As the severity of diabetic retinopathy increased in diabetic patients, the aqueous and serum Apo B / A1 were also increased (P<0.05). Conclusion: The serum and aqueous Apo B/A1 ratio may contribute to the severity of diabetic retinopathy in patients with DRP. Lipid markers may take part in the regulation of diabetes.
Açıklama
Anahtar Kelimeler
Göz Hastalıkları, Eye Diseases
