In-Vitro Anticancer and Antibacterial Activities of Brominated Indeno[1,2-b]qinoline Amines Supported with Molecular Docking and MCDM**

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dc.authoridOkten, Salih/0000-0001-9656-1803
dc.authoridOZCAN, Evrencan/0000-0002-3662-6190
dc.authoridaydin, ali/0000-0002-9550-9111
dc.authoridBulut, Merve/0000-0002-4412-9071
dc.contributor.authorAydin, Ali
dc.contributor.authorOkten, Salih
dc.contributor.authorErkan, Sultan
dc.contributor.authorBulut, Merve
dc.contributor.authorOzcan, Evrencan
dc.contributor.authorTutar, Ahmet
dc.contributor.authorEren, Tamer
dc.date.accessioned2025-01-21T16:42:14Z
dc.date.available2025-01-21T16:42:14Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe present study describes mono substituted indeno[1,2-b]quinolines (3 a-c and 5) have much more antiproliferative potentials than positive controls against A549, HeLa, MCF7 and Hep3B cell lines (IC50 values 1.1-29.6 mu g/mL) and show similar cytotoxicity (14.3 % to 19.8 %) to cells such as controls. Moreover, the mono substituted indeno[1,2-b]quinoline amines (3 a-c and 5) exhibit significant antimicrobial activity with MIC values between 15.62 mu g/mL and 250 mu g/mL. The compounds can also bind to DNA in the groove binding mode with a binding constant range of 1.1x10(3)-1.1x10(5) M-1. The anticancer and antibacterial properties of compounds were confirmed with the molecular docking simulation for their pharmacokinetic. As a result, the preliminary experimental data and a multi-criteria decision-making methodology (MCDM) indicated that the mono substituted indeno[1,2-b]quinoline amine derivatives, especially 3 a and 5, exhibit effective pharmacological properties. parameters and their interaction with related cells at the molecular level.
dc.identifier.doi10.1002/slct.202004753
dc.identifier.endpage3295
dc.identifier.issn2365-6549
dc.identifier.issue13
dc.identifier.startpage3286
dc.identifier.urihttps://doi.org/10.1002/slct.202004753
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25026
dc.identifier.volume6
dc.identifier.wosWOS:000656857900028
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAntibacterial agents; Antitumor agents; Biological activity; Molecular docking; Multi criteria decision making; Indeno[1; 2-b]quinoline amine
dc.titleIn-Vitro Anticancer and Antibacterial Activities of Brominated Indeno[1,2-b]qinoline Amines Supported with Molecular Docking and MCDM**
dc.typeArticle

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