Kedilerde ksilazin, medetomidin ve deksmedetomidinin göz içi basıncına etkisi
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Dosyalar
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Kırıkkale Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Ksilazin, medetomidin ve deksmedetomidin çoğunlukla kedilerde sedasyon ve analjezi amacı ile kullanılan ?2-adrenerjik reseptör agonistleridir. Bu ilaçlar hem sedasyon sırasında göz basıncında değişikliğe hem de kusmaya neden olarak kusma sırasında göz basıncının artmasına neden olurlar. Kediler her grupta 10 hayvan olacak şekilde rastgele 3 gruba ayrıldı. Birinci gruba 1 mg/kg ksilazin, ikinci gruba 80 µg/kg medetomidin ve üçüncü gruba 40 µg/kg deksmedetomidin kas içi yolla uygulandı. Kusan kediler çalışmaya dahil edildi. Kedilerin göziçi basıncı ilaç uygulama öncesinde, kusmadan hemen sonra ve 20 dakika aralıklarla bir saat süresince ölçülerek (T20, T40, T60). değişimler kaydedildi. Sedasyon atipamezol ile antagonize edildikten sonra son ölçüm yapılarak kaydedildi. Tüm gruplarda sedasyon süresinde GİB'in anlamlı düzeyde azaldığı ve gruplar arasında fark olmadığı kaydedildi. GİB'deki düşmenin atipamezol uygulamasından sonra düzeldi. Kusma riski gözönüne alındığında GİB değişikliklerinin önemli olduğu hayvanlarda anestezi protokolü belirlenirken ?2-adrenerjik reseptör agonistlerinin dikkatli kullanılması gerektiği ve GİB' değişikiliklerin atipamezol uygulaması ile antagonize edilebileceği kaydedilmiştir.
?2-adrenergic reseptor agonists such as xylazine, medetomidine and dexmedetomidine are the most popular sedative drugs that are used often in cats to achieve sedation and analgesia These drugs can induce vomiting and alter intraocular pressures (IOP) during vomiting and sedation period. The cats were allocated randomly to one of three groups, each containing 10 animals. The first group was sedated with 1 mg/kg xylazine, the second and the third group was sedated with 80 and 40 µg/kg medetomidine and dexmedetomidine intramusculary, respectively. The cats that vomit were included in the study. IOP were measured before administration, immediately after vomiting, and 20 minutes intervals during 1 hour period (T20, T40, T60). Sedation was reversed with atipamezole and the last measurement were done 20 minutes after atipamezol treatment. IOPs were decreased significantly in all groups and statistically insignificant difference was observed between groups. The alterations in IOP were reversed with atipamezole The results of this study show the risk of vomiting and the associated elevation in IOP after ?2-adrenergic reseptor agonists hould be considered when selecting an anesthetic protocol for a patient with limited tolerance for short-lived increases in IOP. The alterations in IOP can be reversed with atipamezole.
?2-adrenergic reseptor agonists such as xylazine, medetomidine and dexmedetomidine are the most popular sedative drugs that are used often in cats to achieve sedation and analgesia These drugs can induce vomiting and alter intraocular pressures (IOP) during vomiting and sedation period. The cats were allocated randomly to one of three groups, each containing 10 animals. The first group was sedated with 1 mg/kg xylazine, the second and the third group was sedated with 80 and 40 µg/kg medetomidine and dexmedetomidine intramusculary, respectively. The cats that vomit were included in the study. IOP were measured before administration, immediately after vomiting, and 20 minutes intervals during 1 hour period (T20, T40, T60). Sedation was reversed with atipamezole and the last measurement were done 20 minutes after atipamezol treatment. IOPs were decreased significantly in all groups and statistically insignificant difference was observed between groups. The alterations in IOP were reversed with atipamezole The results of this study show the risk of vomiting and the associated elevation in IOP after ?2-adrenergic reseptor agonists hould be considered when selecting an anesthetic protocol for a patient with limited tolerance for short-lived increases in IOP. The alterations in IOP can be reversed with atipamezole.
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Anahtar Kelimeler
Veteriner Hekimliği, Veterinary Medicine, , , , , , , , , , I,
