The Prognostic Importance of Tumor Budding in Intestinal-Type Gastric Adenocarcinoma

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dc.contributor.authorSanioğlu, Gökçe
dc.contributor.authorBostancı, Mustafa Taner
dc.contributor.authorYörübulut, Serap
dc.contributor.authorTürkmenoğlu, Tuğba Taşkın
dc.contributor.authorÖztürk, Gulfidan
dc.contributor.authorDuzkale, Neslihan
dc.date.accessioned2025-01-21T16:17:17Z
dc.date.available2025-01-21T16:17:17Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: Gastric cancer is one of the leading causes of cancer-related deaths. Tumor budding has been\rshown to be a prognostic factor in many cancers. In this study, we aimed to evaluate the prognostic\rsignificance of tumor budding in intestinal-type gastric adenoc arcinoma.\rPatients and Method: A total of 152 cases diagnosed as intestinal type gastric adenocarcinoma in\rthe Pathology Clinic between 2015 and 2021 were included in the study. Tumor budding was grouped\ras low, medium and high. Hematoxylin and eosin-stained slides were re-evaluated in terms of tumor\rdifferentiation, lymphovascular invasion (LVI), perineural invasion (PNI), lymph node involvement, depth\rof invasion (pT) and tumor budding.\rResults: Tumor budding was low in 30.9% (n=47) of the subjects included in the study, moderate in 37.5%\r(n=57) and high in 31.4% (n=48). Statistically, as tumor budding increased, tumor size increased (p<0,05),\rfollow-up times were shortened, survival time (p<0,05), and tumor differentiation (p<0,05) decreased. A\rstatistically significant correlation was observed between tumor budding and LVI (p<0,05), PNI (p<0,05),\rpT(p<0,05), lymph node involvement(p<0,05), and mortality of the cases (p<0,05). No statistically\rsignificant correlation was observed between tumor budding and gender, age, tumor localization and\roperation type (p>0.05).\rConclusion: Tumor budding is associated with poor prognostic factors. As it may be important to guide the\rtreatment modality and follow-up, tumor budding status may be m entioned in routine pathology reports.
dc.identifier.doi10.30733/std.2022.01541
dc.identifier.endpage7
dc.identifier.issn1017-6616
dc.identifier.issn2149-8059
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.trdizinid518423
dc.identifier.urihttps://doi.org/10.30733/std.2022.01541
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/518423
dc.identifier.urihttps://hdl.handle.net/20.500.12587/22606
dc.identifier.volume38
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.relation.ispartofSelçuk Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectGenel ve Dahili Tıp
dc.subjectPatoloji
dc.subjectOnkoloji
dc.titleThe Prognostic Importance of Tumor Budding in Intestinal-Type Gastric Adenocarcinoma
dc.typeArticle

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