Evaluation of Salivary Thiol/Disulfide Homeostasis and Oxidative Stress in Children with Severe Early Childhood Caries Using a Novel Method

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dc.authoridseyithanoglu, muhammed/0000-0002-8027-7549
dc.contributor.authorOnsuren, Asli Sogukpinar
dc.contributor.authorMutluay, Merve
dc.contributor.authorSeyithanoglu, Muhammed
dc.contributor.authorTanriverdi, Burak
dc.date.accessioned2025-01-21T16:40:42Z
dc.date.available2025-01-21T16:40:42Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective This study aimed to assess the role of thiol/disulfide homeostasis and oxidative stress in the saliva of children with severe early childhood caries (S-ECC). Methods Eighty children aged 3 to 6 years were involved in this case-control study. The study consisted of two groups: the study group (S-ECC) and the control group with no caries. Thiol/disulfide homeostasis and antioxidant levels were calculated after obtaining unstimulated saliva samples from all participating children. Results The native/total thiol and total oxidant status (TOS) levels of the study group were higher than those of the control group, though not statistically significant ( p > 0.05). The oxidative stress index (OSI) value was significantly higher in the study group compared to the control group ( p = 0.024). Conclusion Our results confirmed that the thiol/disulfide homeostasis was reduced, and disulfide formation, which is rereducible to thiol, was insufficient in children with S-ECC to compensate oxidative stress compared with the control group. Also, thiol levels were inadequate to compensate for oxidative stress, and thiol/disulfide homeostasis was not an independent parameter for S-ECC. Besides, the increases in the TOS level and OSI value show that oxidative stress had significant effects on S-ECC's etiopathogenesis.
dc.description.sponsorshipKahramanmaras Sutcu Imam University Scientific Research Projects Coordination Unit [2020/1-19M]
dc.description.sponsorshipThis study was funded by Kahramanmaras Sutcu Imam University Scientific Research Projects Coordination Unit (Project Number: 2020/1-19M).
dc.identifier.doi10.1055/s-0042-1753463
dc.identifier.endpage181
dc.identifier.issn1305-7707
dc.identifier.issn1305-7693
dc.identifier.issue4
dc.identifier.startpage175
dc.identifier.urihttps://doi.org/10.1055/s-0042-1753463
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24751
dc.identifier.volume17
dc.identifier.wosWOS:000835007100002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofJournal of Pediatric Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectnative thiol; thiol-disulfide homeostasis; total antioxidant status
dc.titleEvaluation of Salivary Thiol/Disulfide Homeostasis and Oxidative Stress in Children with Severe Early Childhood Caries Using a Novel Method
dc.typeArticle

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