Analysis of cross-transmission and antimicrobial resistance of Pseudomonas aeruginosa and Acinetobacter baumannii isolates causing nosocomial infection in an intensive care unit

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dc.contributor.authorYürüken Z.
dc.contributor.authorİşeri L.
dc.contributor.authorÜnaldi Ö.
dc.contributor.authorDurmaz R.
dc.date.accessioned2020-06-25T15:17:49Z
dc.date.available2020-06-25T15:17:49Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Pseudomonas aeruginosa and Acinetobacter baumannii cause nosocomial infections in intensive care units. We investigated the antimicrobial susceptibility and cross-transmission of these bacteria amongst patients in an intensive care unit. Material and Methods: Thirty-three P. aeruginosa (from 26 patients) and 48 A. baumannii isolates (from 41 patients) responsible for nosocomial infections were isolated from patients between October 2009 and June 2010. Pulsed field gel electrophoresis was used to investigate clonal relationship among isolates. Susceptibility to amikacin, ceftazidime, gentamycin, imipenem, cefepime, piperacillin/tazobactam, aztreonam, and meropenem was examined using the disk diffusion method. Results:P. aeruginosa isolates formed 18 pulsotypes; five of these were clusters including 2 or more strains having indistinguishable PFGE patterns and the remaining 13 were unique. After excluding the repeated samples of the same patients, the clustering rate was estimated as 38.5%. The 48 A. baumannii isolates formed 13 pulsotypes; eight pulsotypes were clusters including totally 41 strains of which five were from repeated samples of five patients. The clustering rate was 87.8% for the isolates obtained from 41 different patients. The antimicrobial resistance rates of P. aeruginosa ranged from 27-39%, but were 45.5-91% for A. baumannii isolates. Conclusion: Despite an implemented infection control program, P. aeruginosa and A. baumannii isolates showed cross-transmission among patients, and the antimicrobial resistance rate of A. baumannii isolates was very high. These findings indicate that the current infection control programs should be reassessed and modifications should be made according to the specific hospital and staffing conditions. © 2016 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/medsci.2015-45078
dc.identifier.endpage6en_US
dc.identifier.issn13000292
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84963546138
dc.identifier.scopusqualityQ4
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2015-45078
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2536
dc.identifier.volume36en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcinetobacter baumanniien_US
dc.subjectPseudomonas aeruginosaen_US
dc.titleAnalysis of cross-transmission and antimicrobial resistance of Pseudomonas aeruginosa and Acinetobacter baumannii isolates causing nosocomial infection in an intensive care uniten_US
dc.title.alternativeBir yoğun bakım ünitesinde hastane enfeksiyonuna neden olan Pseudomonas aeruginosa ve Acinetobacter baumannii izolatlarının çapraz taşınımı ve antimikrobiyal direncinin analizien_US
dc.typeArticle

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