Second Allogeneic Stem Cell Transplantation in Acute Leukemia with Post-Transplantation Relapse

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dc.contributor.authorGüven, Zeynep Tuğba
dc.contributor.authorÇelik, Serhat
dc.contributor.authorEser, Bülent
dc.contributor.authorÇetin, Mustafa
dc.contributor.authorÜnal, Ali
dc.contributor.authorKaynar, Leylagül
dc.date.accessioned2025-01-21T16:11:15Z
dc.date.available2025-01-21T16:11:15Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: It is known that the prognosis of acute leukemia patients who relapse after the first allogeneic stem cell transplantation (ASCT) is dismal. Our goal was to assess the value of a second allogeneic stem cell transplant in acute leukemia patients who experienced post-transplant recurrence. Material and Methods: We retrospectively reviewed data from 29 patients with relapsing acute leukemia who underwent a second ASCT. Nineteen patients with acute myeloid leukemia and ten patients with acute lymphoblastic leukemia were included in the study. Results: Ten AML patients and 10 ALL patients were included in the study. Most patients (62%) were in remission before the second transplantation. The median time between the first and second ASCT was 11.9 months (3.1-42 months). Complete remission (CR) was achieved after the second ASCT in 21 (72%) patients, and 11 (52%) patients relapsed after the second ASCT. During this analysis, six patients (21%) were alive and in remission. Relapse of the disease was the leading cause of mortality. After the second ASCT, overall survival (OS) was 6.34 months, and leukemia-free survival (LFS) was 13.8 months. Conclusion: For patients with acute leukemia who relapsed after the first ASCT, a second ASCT is a good option and can keep patients alive.
dc.identifier.doi10.37990/medr.1259944
dc.identifier.endpage459
dc.identifier.issn2687-4555
dc.identifier.issue3
dc.identifier.startpage455
dc.identifier.trdizinid1263419
dc.identifier.urihttps://doi.org/10.37990/medr.1259944
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1263419
dc.identifier.urihttps://hdl.handle.net/20.500.12587/21425
dc.identifier.volume5
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofMedical records-international medical journal (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subject#BAŞV!
dc.titleSecond Allogeneic Stem Cell Transplantation in Acute Leukemia with Post-Transplantation Relapse
dc.typeArticle

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