The healing effects of prp and thymoquinone on dssinduced inflammatory bowel disease in rats

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dc.contributor.authorÖzden, Hüseyin
dc.contributor.authorKaraca, Gökhan
dc.date.accessioned2025-01-21T16:16:02Z
dc.date.available2025-01-21T16:16:02Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: Crohn's disease and ulcerative colitis are included in inflammatory bowel disease (IBD). The study aimed to compare the healing effects of two promising therapeutic agents: Platelet Rich-Plasma and Thymoquinone (TQ) on DSS induced IBD.Materials and Methods: The animals were divided into three groups as IBD (n=10), PRP treatment (n=10) and TQ treatment (n=10). Experimental IBD was initiated through the oral intake of 5% Dextran Sodium Sulfate (DSS) in drinking water. PRP (0.5 cc) and thymoquinone dissolved in distilled water (100mg/kg) were daily administered rectally to PRP treated group animals for seven days. All animals were sacrificed and rectal tissue calprotectin, lactoferrin and hydroxyproline levels were assessed on the seventh day. Total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) levels were statistically compared.Results: Rectal tissue calprotectin, lactoferrin and hydroxyproline levels were higher in the IBD group (p<0.001, p<0.001 and p<0.001, respectively). TQ treated group animals had lower rectal tissue lactoferrin levels (p<0.011) and TOS and OSI levels (p=0.001 and p=0.001, respectively) than PRP group animals and also the highest antioxidant capacity. Conclusion: Calprotectin, lactoferrin, and hydroxyproline levels are valuable markers in the presence of IBD and response to treatment. Oxidative stress is an important problem that cannot be avoided in unattended cases. Our experimental IBD model found TQ treatment to be more effective in healing than PRP treatment.
dc.identifier.doi10.5455/annalsmedres.2020.08.831
dc.identifier.endpage1499
dc.identifier.issn2636-7688
dc.identifier.issue8
dc.identifier.startpage1496
dc.identifier.trdizinid459522
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2020.08.831
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/459522
dc.identifier.urihttps://hdl.handle.net/20.500.12587/22321
dc.identifier.volume28
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAnnals of Medical Research
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectBiyoloji
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectGenel ve Dahili Tıp
dc.titleThe healing effects of prp and thymoquinone on dssinduced inflammatory bowel disease in rats
dc.typeOther

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