COMPREHENDING COVID-19: IMMUNOPATHOGENIC MECHANISMS OF CYTOKINE ACTION

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dc.contributor.authorAkanbong, Elisha
dc.contributor.authorDevrim, Alparslan Kadir
dc.contributor.authorŞenol, Ali
dc.contributor.authorDevrim, Tuba
dc.date.accessioned2025-01-21T16:19:25Z
dc.date.available2025-01-21T16:19:25Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractCytokine release syndrome (CRS) or cytokine storm is as a result of the excess production of pro-inflammatory cytokines which is due to the disproportionate response of the immune system which can be instigated by SARS-CoV-2. COVID-19 which is caused by SARSCoV- 2 has a correlation with cytokines. SARSCoV- 2 instigates the production of IL-1 by ubiquitous macrophages and mast cells. IL-1 tends to influence the production of IL-6 and TNF-?. The progression of COVID-19 severity influences the level of certain cytokines such as IL-6. IL-6 is the cytokine chiefly responsible for the occurrence of CRS. CRS is the cause of COVID-19-related complications and the main cause of COVID-19-related deaths. Despite the data reported in the literature so far, the relationship between SARS-CoV-2 and cytokines has not been fully elucidated. The aim of the present review is to examine the relationship in question. Targeting cytokines during COVID-19 treatment has the potential to increase patient survival and reduce COVID-19-related deaths. It is concluded that focusing on the mechanisms of cytokine release and the effects of released cytokines, especially examining the effects on T lymphocytes and IFN-? production in COVID-19 disease, may help reduce the lethal effects of the disease.
dc.identifier.doi10.17343/sdutfd.971047
dc.identifier.endpage694
dc.identifier.issn1300-7416
dc.identifier.issn2602-2109
dc.identifier.issue4
dc.identifier.startpage687
dc.identifier.trdizinid502549
dc.identifier.urihttps://doi.org/10.17343/sdutfd.971047
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/502549
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23075
dc.identifier.volume28
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofSüleyman Demirel Üniversitesi Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectGenel ve Dahili Tıp
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.subjectİmmünoloji
dc.titleCOMPREHENDING COVID-19: IMMUNOPATHOGENIC MECHANISMS OF CYTOKINE ACTION
dc.typeReview Article

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